Antibacterial Activity of Nanosilver Ions and Particles

Sotiriou, Georgios A.; Pratsinis, Sotiris E.

doi:10.1021/es101072s

Cited by 755 publications

(664 citation statements)

References 27 publications

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“…Mahmoodzadeh et al (2013) reported that direct exposure to specific types of nanoparticles causes significant phytotoxicity, emphasizes the need for ecologically responsible disposal of wastes containing nanoparticles and also highlights the necessity for further study on the impacts of nanoparticles on agricultural and environmental systems. The toxicity of AgNPs has been investigated in different terrestrial and aquatic organisms and was found to be related to their bioaccumulation effect of silver (Georgios & Sotiris, 2010).…”

Section: Introductionmentioning

confidence: 99%

Green Synthesis of Silver Nanoparticles Using Leaf Extract of Rosmarinus officinalis and Its Effect on Tomato and Wheat Plants

Farghaly¹,

Nafady²

2015

JAS

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Biological green synthesis of silver nanoparticles (AgNPs) from silver salts is a growing advanced approach to avoid the requirement of costly instruments and involvement of hazardous chemicals as well. However, increasing use of AgNPs raises potential toxicity level in the environment. In this investigation, leaf extract of rosemary (Rosmarinus officinalis) used as a reducing and stabilizing agent for biosynthesis of AgNPs. The biosynthesized AgNPs were authorized by UV-vis spectrophotometer and X-ray diffraction (XRD) analysis. The shape and size of the biosynthesized AgNPs were studied using high resolution transmission electron microscope (TEM). The toxicity of the biosynthesized silver nanoparticles on wheat and tomato plants was studied by soaking wheat grains and tomato seeds in 100 mg/L AgNPs and follow its effect on seedling growth of wheat (at 10 days) and on vegetative growth of tomato and wheat plants (at 35 days). Some physiological parameters as germination percentage of wheat seedling, length of seedling, dry weight, pigment fractions (chl.a, chl.b and caroteinoids), soluble proteins, lipid peroxidation (MDA) and antioxidant enzymes (catalase and peroxidase) of two plants were measured. AgNPs has a non-significant inhibitory effect on germination percentage of wheat, dry weight and pigment fractions. The biosynthesized AgNPs has a noticeable stress effect on tomato plant as reduced chlorophyll a and dry weight. Generally, AgNPs stimulate MDA accumulation in tomato and wheat plants. There was a noticeable different effect of AgNPs on soluble proteins and antioxidant enzymes as catalase and peroxidase among tomato and wheat plants.

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Section: Introductionmentioning

confidence: 99%

Green Synthesis of Silver Nanoparticles Using Leaf Extract of Rosmarinus officinalis and Its Effect on Tomato and Wheat Plants

Farghaly¹,

Nafady²

2015

JAS

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“…It is difficult to differentiate between antibacterial effects of ionic silver and Ag nanoparticles as all nanoparticles release a degree of silver ions [15,16]. The antimicrobial effect of silver is thought to be the combination of several mechanisms of action; for example, silver ions and small silver nanoparticles (Ag-NPs) (less than 10nm) have been shown capable of entering the bacterial cytoplasm and inhibit cell growth [17].…”

Section: Introductionmentioning

confidence: 99%

Biogenic synthesis of antimicrobial silver nanoparticles capped with l-cysteine

Perni

Hakala

Prokopovich

2014

Colloids and Surfaces A: Physicochemical and Engineering Aspect

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The number of medical applications of silver nanoparticles is constantly expanding due to their high bactericidal properties coupled with low toxicity towards mammalian cells. Because of this expanding use of silver nanoparticles, novel methods of synthesis have been developed in order to achieve nanoparticles preparation through inexpensive and environmentally friendly processes; biogenic synthesis of silver nanoparticles is an approach that meets those requirements.In this work, E. coli cultures centrigugates were used to synthesis L-cysteine capped silver nanoparticles. The ratio between AgNO 3 and L-cysteine has been proven to affect the size of the nanoparticles: higher amount of L-cysteine returns smaller nanoparticles, but does not affect the percentage of organic matter in the nanoparticles as determined through TGA.The silver nanoparticles prepared had antimicrobial activity against E. coli and S. aureus with Minimum Inhibitory Concentration (MIC) and Minimum Bactericidal Concentration (MBC) independent of the nanoparticles size; for both bacterial species the values of MIC and MBC were the same, 0.0432 mg/ml for E. coli and 0.0216 mg/ml for S. aureus.

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“…However, many adverse toxicological effects on living organisms are still reported. Generally, it is recognized that toxicity and antibacterial activity are related to the release of Ag+ ions from the Ag NPs [6] but the efficiency of these effects can be modulated by the NPs uptake or the interaction of NPs with different biological compartments [7,8]. Colloidal aqueous suspension of spherical Ag NPs of 7-20 nm induce cytotoxicity on primary mouse fibroblasts and primary liver cells; moreover they induce oxidative stress as reduction in the glutathione (GSH) level, and increase of reactive oxygen species (ROS) and lipid peroxidation on human skin carcinoma cells (A431) and human fibrosarcoma cells (HT-1080) [9,10].…”

Section: Introductionmentioning

confidence: 99%

Silver nanoparticles induce cytotoxicity, but not cell transformation or genotoxicity on Balb3T3 mouse fibroblasts

Broggi¹,

Ponti²,

Giudetti

et al. 2013

BioNanoMaterials

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Silver nanoparticles (Ag NPs) are one of the most common nanomaterials present in nanotechnologybased products. Here, the physical chemical properties of Ag NPs suspensions of 44 nm, 84 nm and 100 nm sizes synthesized in our laboratory were characterized. The NM-300 material (average size of 17 nm), supplied by the Joint Research Centre Nanomaterials Repository was also included in the present study. The Ag NPs potential cytotoxicity was tested on the Balb3T3 cell line by the Colony Forming Efficiency assay, while their potential morphological neoplastic transformation and genotoxicity were tested by the Cell Transformation Assay and the micronucleus test, respectively. After 24 h of exposure, NM-300 showed cytotoxicity with an IC50 of 8 µM (corresponding to 0.88 µg/mL) while for the other nanomaterials tested, values of IC50 were higher than 10 µM (1.10 µg/mL). After 72 h of exposure, Ag NPs showed size-dependent cytotoxic effect with IC50 values of 1.5 µM (1.16 µg/mL) for NM-300, 1.7 µM (1.19 µg/mL) for Ag 44 nm, 1.9 µM (0.21 µg/mL) for Ag 84 nm and 3.2 µM (0.35 µg/mL) for Ag 100 nm. None of the Ag NPs tested was able to induce either morphological neoplastic transformation or micronuclei formation.

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Antibacterial Activity of Nanosilver Ions and Particles

Cited by 755 publications

References 27 publications

Green Synthesis of Silver Nanoparticles Using Leaf Extract of Rosmarinus officinalis and Its Effect on Tomato and Wheat Plants

Green Synthesis of Silver Nanoparticles Using Leaf Extract of Rosmarinus officinalis and Its Effect on Tomato and Wheat Plants

Biogenic synthesis of antimicrobial silver nanoparticles capped with l-cysteine

Silver nanoparticles induce cytotoxicity, but not cell transformation or genotoxicity on Balb3T3 mouse fibroblasts

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