Antibacterial Activity of Nanostructured Polyaniline Combined With Mupirocin

Abstract

Nanostructured and conducting polymer polyaniline (PANI) is used in numerous applications in electrotherapy, electro-magnetic materials for monitoring health, antimicrobial clothing, data transfer in smart textiles, biosensors and for defense technology. An important criterion for all the above mentioned utilities is, producing polymeric conductive fibers. In the present study we prepared conducting PANI nanofibres combined with mupirocin, a topical antimicrobial agent, through a self-assembly process. The prepared polymer was then tested for the antibacterial properties against various Gram positive and Gram negative bacteria such as Streptococcus pyogenes, Staphylococcus epidermidis, Staphylococcus aureus and Escherichia coli. Scanning electron microscopy (SEM) and Fourier transform infrared spectroscopy (FTIR) were used to identify the chemical structure of the PANI nanofibres. The antibacterial properties were assessed by measuring the zones of inhibition. It was evident from these results that antimicrobial activity increased with increasing PANI and PANI combined with mupirocin (PANI-mupirocin) concentrations. It was also found that PANI-mupirocin has enhanced antimicrobial activity compared to PANI alone. This information might be useful to evaluate the potential use of nanostructured polyaniline in fabrics incorporated with antibacterial agents as a prophylactic use against bacterial skin infections in the near future.

Enhanced functionality of colloidal polyaniline/polyvinyl alcohol nanocomposite as an antibacterial agent

“…These results (Table 2) are consistent with previously reported data [13][14][15] showing that PAn has an intrinsic antibacterial effect.…”

“…Gizdavic-Nikolaidis et al [13] reported that the MIC values of PAn against E. coli, S. aureus, and P. aeruginosa are in the range of 1.25-10 mg ml 21 . These results ( Table 2) are consistent with previously reported data [13][14][15] showing that PAn has an intrinsic antibacterial effect.…”

“…Jia et al [14] reported that the combination of silver (Ag) nanoparticles and PAn has a synergistic antimicrobial efficiency on E. coli, S. aureus, and yeast bacteria. Jotiram et al [15] also reported antibacterial activity of PAnmupirocin nanocomposite against gram-positive and gram-negative bacteria, such as S. pyogenes, S. epidermidis, S. aureus, and E. coli. The amine and imine group present in various natural, natural-derived, and nonnatural compounds, such as Schiff bases, has been shown to be critical to their biological activities, including antibacterial, antifungal, and antipyretic properties.…”

Antibacterial Activity of Poly(aniline-co-ethylaniline) againstStaphylococcus aureusandPseudomonas aeruginosa

“…Therefore, the use of polymeric materials with antimicrobial properties gains an increasing interest from both academic and industrial point of view. Conducting polymers have become one of the most attractive subjects of antimicrobial polymers investigation in recent years [9,[23][24][25] .…”

Chemical Copolymerization and Characterization of Colloidal Poly(aniline‐co‐3‐aminobenzoic acid) as a High‐Performance Antibacterial Polymer

“…Processability is an important requirement in CPs for their possible commercial use. 10,20,21 In the present work, we report a new approach to the synthesis of functionalized PAn as an antimicrobial polymer. Several methodologies have been developed to solve this problem, including the addition of side groups to the polymer backbone, grafting of polymers to a non-CP, direct polymerization of intractable polymers into the final desired shape, making a composite of blend of CPs, copolymerization of aniline with its derivatives, and preparation of the colloidal form of PAn.…”