Antibacterial Activity of Organic and Aqueous Extracts of Hopea odorata Roxb. Leaves and their Total Flavonoid Content

Kabir, Mohammad Shah Hafez; Noman, Muhammad Abdulla Al; Rahman, Md. Mominur; Ara, Joushan; Hossain, Mohammed Kamal; Hasanat, Abul; Zaheed, Fahima

doi:10.9734/bmrj/2015/19186

Cited by 5 publications

(4 citation statements)

References 19 publications

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“…Phytochemical studies reported that the heartwood of H. odorata contains certain types of phenolic compounds [23]. These polyphenols are reported useful as antioxidants, antibacterial, anti-inflammatory, antimutagens, scavengers of free radicals and therefore have implications in the prevention of pathologies such as cancer and cardiovascular disease [24]. Methanol extract of Hopea odorata suppresses inflammatory responses via the direct inhibition of multiple kinases.…”

Section: Introductionmentioning

confidence: 99%

Antioxidant, antidiarrheal, hypoglycemic and thrombolytic activities of organic and aqueous extracts of Hopea odorata leaves and in silico PASS prediction of its isolated compounds

Kabir

Hossain

Kabir

et al. 2016

BMC Complement Altern Med

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Background Hopea Odorata, locally known as Telsur (Bangladesh), has some traditional uses as folk medicine. This study aims to investigate the antioxidant, antidiarrheal, hypoglycemic and thrombolytic activities of H. odorata leaf extracts as new therapeutic prospects predicting the activity of some of the isolated compounds of this plant.MethodsLeaves of Hopea odorata was extracted with pure methanol (MEHO), ethanol (EEHO) and water (AEHO). The extract was tested for antioxidant activity by using reducing power and H2O2 scavenging assay. Antidiarrheal effects were assayed by three standard methods of bioassay: Castor oil-induced diarrhea, Castor oil induced enteropooling and gastrointestinal transit test. Hypoglycemic effect was determined by normoglycemic model of mice. Thrombolytic activity was evaluated by clot lyses test for human and mice blood. In silico PASS prediction was applied for phytoconstituents namely Balanocarpol, Hopeaphenol and Ampelopsin H isolated from this plant. ResultAmong the all extracts, MEHO exhibited strong antioxidant activity in both reducing power and H2O2 scavenging assay. Phenol content of MEHO was 297.22 ± 0.78 mg/g and flavonol content was 91.53 ± 1.82 mg/g. All the experiment of extracts at dose of 200 and 400 mg/kg and the standard drug loperamide (5 mg/kg) showed significant (p < 0.001) inhibition against castor oil induced diarrhea and castor oil induced enteropooling in mice. There were also significant (p < 0.01) reduction in gastrointestinal motility in the charcoal meal test. Leaf extract showed no significant (P < 0.01) decrease of blood glucose compared to Glibenclamide in normoglycemic mice. Using an in vitro thrombolytic model, MEHO showed the highest and significant clot lysis of human and mice blood compared to Streptokinase. PASS predicted the wide range of antioxidant, free radical scavenger, Nitric oxide scavenger, cardioprotectant, hepatoprotectant, thrombolytic, fibrinolytic, antibacterial, antifungal, anticarcinogenic, anthelmintic and anti-inflammatory activity of examined phytoconstituents.ConclusionThese findings suggest that the plant may be a potential source of new antidiarrheal, thrombolytic and antioxidative agents but it is found to have no antidiabetic capability. PASS prediction matched with present study for the extracts. Further study needs to identify the PASS predicted biological actions of the phytoconstituents.Electronic supplementary materialThe online version of this article (doi:10.1186/s12906-016-1461-x) contains supplementary material, which is available to authorized users.

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Section: Introductionmentioning

confidence: 99%

Antioxidant, antidiarrheal, hypoglycemic and thrombolytic activities of organic and aqueous extracts of Hopea odorata leaves and in silico PASS prediction of its isolated compounds

Kabir

Hossain

Kabir

et al. 2016

BMC Complement Altern Med

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“…The total flavonoid content was expressed as equivalents of quercetin. Furthermore, calibration curve was prepared by a standard solution of quercetin [12,14]. …”

Section: Methodsmentioning

confidence: 99%

The Determination of Blood Glucose Lowering and Metabolic Effects of Mespilus germanica L. Hydroacetonic Extract on Streptozocin-Induced Diabetic Balb/c Mice

et al. 2018

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Background: The serum glucose lowering, normalization animal body weight, and antioxidative stress effects of Mespilus germanica L. leaf extract were investigated in normal and streptozotocin-induced Balb/C mice. Methods: The phenol and flavonoid of the leaves of M. germanica were extracted by percolation and concentrated using a rotary evaporator. Its total phenol and flavonoid content was determined using folin and aluminum chloride methods, respectively. The study was conducted on 48 matured male Balb/C mice (20–30 g) divided into 6 groups (n = 8). Diabetes mellitus was induced by single intraperitoneal injection of 35 mg/kg of streptozotocin (STZ). Extracts of Mespilus germanica were used orally at the dose of 50, 100, and 200 mg/kg body weight per day for 21 days. Results: Oral administrations of the M. germanica L. leaf extract significantly decreased serum glucose, oxidative stress, and lipid peroxidation and maintained animal body weight during treatment period (p < 0.05) compared to metformin (200 mg/kg) in over 100 mg/kg, 200 mg/kg, and 50 mg/kg dosages, respectively. Conclusions: The present study indicated that the Mespilus germanica leaf extract significantly decreased serum glucose and maintained normal body weight in Balb/C diabetic mice.

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“…The antibacterial effects were tested by the disc diffusion method with some minor modification [17,18]. The filter paper discs (5 mm in diameter) were individually impregnated with 24 µL of 800 µg/ disk and 30 µL of 1 000 µg/disk of different plant extracts and then placed onto the agar plates which had previously been inoculated with the test microorganisms (within 15 min).…”

Section: Antimicrobial Screening By Disk Diffusion Techniquementioning

confidence: 99%

Comparative study of hypoglycemic and antibacterial activity of organic extracts of four Bangladeshi plants

Kabir¹,

Ahmad²,

Mahamoud³

et al. 2016

J Coast Life Med

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Antibacterial Activity of Organic and Aqueous Extracts of Hopea odorata Roxb. Leaves and their Total Flavonoid Content

Cited by 5 publications

References 19 publications

Antioxidant, antidiarrheal, hypoglycemic and thrombolytic activities of organic and aqueous extracts of Hopea odorata leaves and in silico PASS prediction of its isolated compounds

Antioxidant, antidiarrheal, hypoglycemic and thrombolytic activities of organic and aqueous extracts of Hopea odorata leaves and in silico PASS prediction of its isolated compounds

The Determination of Blood Glucose Lowering and Metabolic Effects of Mespilus germanica L. Hydroacetonic Extract on Streptozocin-Induced Diabetic Balb/c Mice

Comparative study of hypoglycemic and antibacterial activity of organic extracts of four Bangladeshi plants

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