Antibacterial activity of recently approved antibiotics against methicillin-resistant Staphylococcus aureus (MRSA) strains: A systematic review and meta-analysis

Liu, Fei; Rajabi, Sajad; Shi, Chao; Afifirad, Ghazale; Omidi, Nazanin; Kouhsari, Ebrahim; Khoshnood, Saeed; Azizian, Khalil

doi:10.1186/s12941-022-00529-z

Cited by 20 publications

(12 citation statements)

References 74 publications

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“…The concentration of tedizolid that inhibited 90% of the present MRSA isolates (MIC 90 ) was 0.38 µg/mL, 2.6-fold lower than linezolid (MIC 90 , 1 µg/mL). Similarly, the findings of a recently published systematic review and meta-analysis demonstrated that the in vitro activity of tedizolid in 12,204 MRSA isolates was 0.25 and 0.50 µg/mL for MIC 50 and MIC 90, respectively [21]. A Korean multicenter study comparing the activities of tedizolid to those of linezolid for MRSA recovered from patients with SSTIs reported that the MIC 90 of tedizolid was 0.5 µg/mL, 4-fold lower than linezolid (MIC 90 , 2 µg/mL) [57].…”

Section: Discussionmentioning

confidence: 60%

“…Similarly, a recent systematic review reported that the overall antibacterial activity of dalbavancin on 28,539 MRSA isolates was 0.060 and 0.120 µg/mL for MIC 50 and MIC 90 , respectively. Out of 11 studies, the pooled prevalence of dalbavancin susceptibility was 100% (95% CI: 100-100) [21]. It has been also shown that the dalbavancin MICs of VISA and heteroresistant VISA (hVISA) strains were 4-to 8-fold lower than vancomycin [51].…”

Section: Discussionmentioning

confidence: 99%

“…The recurrence of the infection may occur in up to 75% of inappropriately managed SSTIs caused by CA-MRSA [17,18]. In order to improve the management of infections caused by MRSA, new antibiotics, including ceftobiprole, dalbavancin and tedizolid, have been introduced into the therapeutic armamentarium for SSTIs [19][20][21][22][23][24][25][26] (Table 1).…”

Section: Introductionmentioning

confidence: 99%

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In Vitro Activities of Ceftobiprole, Dalbavancin, Tedizolid and Comparators against Clinical Isolates of Methicillin-Resistant Staphylococcus aureus Associated with Skin and Soft Tissue Infections

et al. 2023

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Skin and soft tissue infections (SSTIs) are associated with significant morbidity and healthcare costs, especially when caused by methicillin-resistant Staphylococcus aureus (MRSA). Vancomycin is a preferred antimicrobial therapy for the management of complicated SSTIs (cSSTIs) caused by MRSA, with linezolid and daptomycin regarded as alternative therapeutic options. Due to the increased rates of antimicrobial resistance in MRSA, several new antibiotics with activity against MRSA have been recently introduced in clinical practice, including ceftobiprole, dalbavancin, and tedizolid. We evaluated the in vitro activities of the aforementioned antibiotics against 124 clinical isolates of MRSA obtained from consecutive patients with SSTIs during the study period (2020–2022). Minimum inhibitory concentrations (MICs) for vancomycin, daptomycin, ceftobiprole, dalbavancin, linezolid and tedizolid were evaluated by the MIC Test Strip using Liofilchem strips. We found that when compared to the in vitro activity of vancomycin (MIC90 = 2 μg/mL), dalbavancin possessed the lowest MIC90 (MIC90 = 0.094 μg/mL), followed by tedizolid (MIC90 = 0.38 μg/mL), linezolid, ceftobiprole, and daptomycin (MIC90 = 1 μg/mL). Dalbavancin demonstrated significantly lower MIC50 and MIC90 values compared to vancomycin (0.064 vs. 1 and 0.094 vs. 2, respectively). Tedizolid exhibited an almost threefold greater level of in vitro activity than linezolid, and also had superior in vitro activity compared to ceftobiprole, daptomycin and vancomycin. Multidrug-resistant (MDR) phenotypes were detected among 71.8% of the isolates. In conclusion, ceftobiprole, dalbavancin and tedizolid exhibited potent activity against MRSA and are promising antimicrobials in the management of SSTIs caused by MRSA.

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Section: Discussionmentioning

confidence: 60%

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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In Vitro Activities of Ceftobiprole, Dalbavancin, Tedizolid and Comparators against Clinical Isolates of Methicillin-Resistant Staphylococcus aureus Associated with Skin and Soft Tissue Infections

et al. 2023

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“…S. aureus is a common cause of community and hospital-acquired infection ( 58 , 59 ). The WHO has regarded it as one of the primary clinical concerns, due to the global recognition of MRSA as a public health issue and the antibiotic resistance pattern of MRSA ( 60 ). The primary issue with MRSA is the incidence of multidrug resistance, which remains high ( 61 ).…”

Section: Discussionmentioning

confidence: 99%

Current molecular approach for diagnosis of MRSA: a meta-narrative review

Sim

Lee

Abushelaibi

et al. 2022

dti

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Introduction: Detection and diagnosis of MRSA are important in ensuring a correct and effective treatment, further reducing its spread. There are a wide range of molecular approaches for the diagnosis of AMR in MRSA, including PCR, MLST and SCCmec. This review aims to study and appraise current molecular diagnostic methods used for the detection of MRSA. Method: This narrative review was performed by searching the PubMed using the following search terms: (molecular diagnosis) AND (antimicrobial resistance) NOT (review [publication type)) NOT (systematic review [publication type)) NOT (meta-analysis[publication type)) AND (methicillin-resistant staphylococcus aureus). Studies using molecular diagnostic techniques for the detection of MRSA were included, while non-English language, duplicates, and non-article studies were excluded. After reviewing the libraries and a further manual search, 20 studies were included in this paper. RAMESES publication standard for narrative reviews was used for this synthesis. Results: Of the 20 studies included, 11 studies employed PCR for diagnosing MRSA , 2 studies on DNA Microarray, Xpert MRSA/SA BC assay (n=1), MALDI-TOF (n=2), MLST (n=5) and SCCMec typing (n=1). Discussion: Different diagnostic methods used for the diagnosis of MRSA have been studied in this review. Each diagnostic technique have its benefits and drawbacks, however, this study concludes that PCR has been extensively used due to its increased sensitivity and cost-effectiveness.

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“…MRSA is the most studied bacteria in antibacterial assays employing NFs containing phytochemicals. Its widespread prevalence and ability to cause a range of infections, as well as its AMR to antibiotics, make MRSA a useful model organism for studying antibacterial agents and mechanisms of action [ 93 ].…”

Section: Nanofibersmentioning

confidence: 99%

Phytochemical-Based Nanomaterials against Antibiotic-Resistant Bacteria: An Updated Review

et al. 2023

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Antibiotic-resistant bacteria (ARB) is a growing global health threat, leading to the search for alternative strategies to combat bacterial infections. Phytochemicals, which are naturally occurring compounds found in plants, have shown potential as antimicrobial agents; however, therapy with these agents has certain limitations. The use of nanotechnology combined with antibacterial phytochemicals could help achieve greater antibacterial capacity against ARB by providing improved mechanical, physicochemical, biopharmaceutical, bioavailability, morphological or release properties. This review aims to provide an updated overview of the current state of research on the use of phytochemical-based nanomaterials for the treatment against ARB, with a special focus on polymeric nanofibers and nanoparticles. The review discusses the various types of phytochemicals that have been incorporated into different nanomaterials, the methods used to synthesize these materials, and the results of studies evaluating their antimicrobial activity. The challenges and limitations of using phytochemical-based nanomaterials, as well as future directions for research in this field, are also considered here. Overall, this review highlights the potential of phytochemical-based nanomaterials as a promising strategy for the treatment against ARB, but also stresses the need for further studies to fully understand their mechanisms of action and optimize their use in clinical settings.

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Antibacterial activity of recently approved antibiotics against methicillin-resistant Staphylococcus aureus (MRSA) strains: A systematic review and meta-analysis

Cited by 20 publications

References 74 publications

In Vitro Activities of Ceftobiprole, Dalbavancin, Tedizolid and Comparators against Clinical Isolates of Methicillin-Resistant Staphylococcus aureus Associated with Skin and Soft Tissue Infections

In Vitro Activities of Ceftobiprole, Dalbavancin, Tedizolid and Comparators against Clinical Isolates of Methicillin-Resistant Staphylococcus aureus Associated with Skin and Soft Tissue Infections

Current molecular approach for diagnosis of MRSA: a meta-narrative review

Phytochemical-Based Nanomaterials against Antibiotic-Resistant Bacteria: An Updated Review

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