Antibacterial activity of remifentanil and mixtures of remifentanil and propofol

Apan, Teoman Zafer; Apan, Alpaslan; Sahin, S.; Çakırca, Mehmet

doi:10.1016/j.jclinane.2007.02.005

Cited by 17 publications

(9 citation statements)

References 25 publications

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“…10 Remifentanil, which is an analog of fentanyl, was also stated to decrease bacterial growth. 16,17 Tamai-Shacooriz et al in their investigation, reported that sufentanil increased the antibacterial activity of bupivacaine but not ropivacaine. 9 Antibacterial effect of lidocaine was shown in several investigations.…”

Section: Discussionmentioning

confidence: 97%

Growth of Microorganisms in Propofol and Mixture of Propofol, Lidocaine and Fentanyl

Altan

Bonabi

Kesi̇ci̇

et al. 2019

J Coll Physicians Surg Pak

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Section: Discussionmentioning

confidence: 97%

Growth of Microorganisms in Propofol and Mixture of Propofol, Lidocaine and Fentanyl

Altan

Bonabi

Kesi̇ci̇

et al. 2019

J Coll Physicians Surg Pak

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“…A fentanyl analog “remifentanil” was investigated by Apan et al . [ 17 ] in the same manner. They have observed similar microbial inhibition on S. aureus , P. aeruginosa , E. coli and C. albicans depending on the concentration.…”

Section: Discussionmentioning

confidence: 99%

Investigating antimicrobial features and drug interactions of sedoanalgesics in intensive care unit: an experimental study

et al. 2021

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Study Objective: Aim of this study was to evaluate antimicrobial effects and interaction between analgesic combinations of fentanyl citrate, dexmedetomidine hydrochloride and tramadol hydrochloride on Staphylococcus aureus, Klebsiella pneumoniae, Escherichia coli, Pseudomonas aeruginosa and Candida albicans which are some of the most common nosocomial infection related microorganisms. Design: In vitro prospective study. Setting: University Clinical Microbiology Laboratory. Measurements: In order to evaluate in vitro antimicrobial effects and interaction between analgesic combinations, tramadol hydrochloride, fentanyl citrate and dexmedetomidin were used against S. aureus ATCC 29213, K. pneumoniae, E. coli ATCC 25922, P. aeruginosa ATCC 27853 and C. albicans ATCC 10231 standard strains by microdilution method. Main Results: According to microdilution assays tramadol has shown the most efficient antimicrobial activity also it has been observed that 10 mg/ml concentrated dexmedetomidine has antimicrobial effects on S. aureus, K. pneumoniae and P. aeruginosa. Fentanyl has displayed evident inhibitory potency on the pathogens except for Klebsiella pneumoniae, nevertheless our predefined minimum concentration inhibited growth by 9.5 %. Fentanyl and dexmedetomidine together exhibited more antimicrobial effect on P. aeruginosa and E. coli growth. Additionally, when the three drugs examined together, microbial inhibition occurred more than expected on E. coli again and also on C. albicans growth. Conclusions: Our results revealed the antimicrobial properties and synergy with the different combinations of fentanyl, dexmedetomidine and tramadol against the most common nosocomial infection agents in the ICU. This is the first study in the literature looking into the microbial “interactions” of opioids and sedative drugs but more research is needed in order to define clinico-laboratory correlation. ©2021 by the authors. This article is an open-access article distributed under the terms and conditions of the Creative Commons Attribution license (http://creativecommons.org/licenses/by/4.0/).

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“…Apan et al found that the growth of E. coli was less affected compared with other agents when an agent known to inhibit E. coli reproduction (remifentanil) was added to propofol. they emphasized that the lipid content of propofol highly facilitated bacterial growth, and attentive aseptic conditions must be observed while using propofol to avoid any possible contamination (17). A study investigating how heat and the inclusion of lidocaine into propofol affected bacterial contamination showed that less bacterial growth was detected in samples preserved in sterilized injectors compared with those preserved as open ampules.…”

Section: Discussionmentioning

confidence: 99%

Can different fatty acid contents in propofol formulations change bacterial growth?

Ertaş¹,

Andan²,

Yücel³

et al. 2018

Med J Islamic World Acad Sci

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Antibacterial activity of remifentanil and mixtures of remifentanil and propofol

Cited by 17 publications

References 25 publications

Growth of Microorganisms in Propofol and Mixture of Propofol, Lidocaine and Fentanyl

Growth of Microorganisms in Propofol and Mixture of Propofol, Lidocaine and Fentanyl

Investigating antimicrobial features and drug interactions of sedoanalgesics in intensive care unit: an experimental study

Can different fatty acid contents in propofol formulations change bacterial growth?

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