Antibacterial activity of resin composites containing surface pre-reacted glass-ionomer (S-PRG) filler

Miki, Saeki; Kitagawa, Haruaki; Kitagawa, Ranna; Kiba, Wakako; Hayashi, Mikako; Imazato, Satoshi

doi:10.1016/j.dental.2016.06.018

Cited by 85 publications

(90 citation statements)

References 26 publications

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“…Taken together, previous findings (Miki et al, ) and our data suggest that metal ions, such as boric acid, which are incorporated into the periodontal connective tissue, are capable of preventing the progression of bone resorption induced by inflammatory cytokines and that they play an important role in bone metabolism. We propose that the eluate of the S‐PRG filler could develop as a component of the oral rinsing solution as Suzuki et al reported (Suzuki et al, ).…”

Section: Discussionsupporting

confidence: 90%

“…Recently, the bactericidal activity of materials coated with metal and metalloid ions has led to the suggestion that they may be used as novel anti-bacterial therapeutics against periodontal bacteria, as well as antibiotics (Goudouri, Kontonasaki, Lohbauer, & Boccaccini, 2014). A surface pre-reacted glass ionomer (S-PRG) filler is able to release six ions-fluoride (F), strontium (Sr), sodium (Na), boron (B), aluminum (Al), and silica (Si)-and has been shown to possess properties such as the prevention of demineralization, promotion of remineralization, and bactericidal activity (Fujimoto et al, 2010;Han & Okiji, 2011;Hosoya et al, 2013;Miki et al, 2016;Murayama et al, 2012;Saku, et al, 2010). It has been reported that S-PRG eluate inhibits the protease and gelatinase activities of P. gingivalis and suppresses co-aggregation between P. gingivalis and Fusobacterium nucleatum (Yoneda et al, 2012).…”

Section: Introductionmentioning

confidence: 99%

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Metal ions from S‐PRG filler have the potential to prevent periodontal disease

Iwamatsu-Kobayashi

Abe

Fujieda

et al. 2017

Clinical & Exp Dental Res

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The surface pre‐reacted glass ionomer (S‐PRG) filler, a component of composite resin, is capable of releasing metal ions that possess antibacterial activity against caries and periodontal pathogens. Although S‐PRG has been suggested to be involved in oral disease prevention, no reports have been published regarding its preventive effect on periodontal disease in vivo. The present study investigated whether the eluate from S‐PRG (S‐PRG eluate) has a suppressive effect on tissue destruction induced in a mouse model of ligature‐induced periodontal disease. Twenty‐seven C57BL/6 mice were divided into three groups of nine animals each, no ligature group (Lig(−)), ligature group (Lig(+)S‐PRG(−)) and ligature with S‐PRG eluate group (Lig(+)S‐PRG(+)). Alveolar bone loss was evaluated using micro‐computed tomography scanning. Histologic changes were detected by hematoxylin and eosin staining. The infiltration of inflammatory cells was assessed by Ly6G and F4/80 staining immunohistochemically. The distribution of metal ions was detected by time‐of‐flight secondary ion mass spectrometry. S‐PRG eluate clearly inhibited alveolar bone loss and bone density. The histological analysis revealed that S‐PRG eluate reduced destruction of the collagen bundle in the periodontal ligament and the infiltration of inflammatory cells. Immunohistochemical analysis showed that the S‐PRG eluate significantly suppressed the number of infiltrating neutrophils and macrophages. Time‐of‐flight secondary ion mass spectrometry analysis revealed that more boron ions were present in the Lig(+)S‐PRG(+) group than in the Lig(+)S‐PRG(−) group. Our results suggest that the S‐PRG eluate has a preventive effect against tissue destruction in periodontal disease through its anti‐inflammatory effects in vivo.

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Section: Discussionsupporting

confidence: 90%

Section: Introductionmentioning

confidence: 99%

Metal ions from S‐PRG filler have the potential to prevent periodontal disease

Iwamatsu-Kobayashi

Abe

Fujieda

et al. 2017

Clinical & Exp Dental Res

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“…90 It was also found that addition of fluoride glass fillers to PMMA decreased microbial adhesion, although it slightly increased surface roughness of the denture base resin. [91][92][93] Nanoclay is another material which is used to improve the properties of composite and acrylic polymers. The addition of Nanoclay particles to PMMA improved its thermal conductivity, while it had a negative effect on the flexural strength.…”

Section: Mineralsmentioning

confidence: 99%

PMMA denture base material enhancement: a review of fiber, filler, and nanofiller addition

Gad

Fouda

Al‐Harbi

et al. 2017

IJN

323

319

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This paper reviews acrylic denture base resin enhancement during the past few decades. Specific attention is given to the effect of fiber, filler, and nanofiller addition on poly(methyl methacrylate) (PMMA) properties. The review is based on scientific reviews, papers, and abstracts, as well as studies concerning the effect of additives, fibers, fillers, and reinforcement materials on PMMA, published between 1974 and 2016. Many studies have reported improvement of PMMA denture base material with the addition of fillers, fibers, nanofiller, and hybrid reinforcement. However, most of the studies were limited to in vitro investigations without bioactivity and clinical implications. Considering the findings of the review, there is no ideal denture base material, but the properties of PMMA could be improved with some modifications, especially with silanized nanoparticle addition and a hybrid reinforcement system.

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“…1,6,7 Although different bacteriostatic and bactericide chemicals such as chlorhexidine, Ag-salts and particles, and oxides have been previously incorporated into composite resins to confer antibacterial activity to them, they could potentially jeopardize the composites' physicochemical properties. 7,8 Moreover, a recent study found that the incorporation of various nanoparticles into adhesive materials may have negative effects on the shear bond strength. 9 Besides adding active antimicrobial ingredients to the dental materials, another strategy for bacterial reduction is coating surfaces with antibacterial agents to create anti-adhesive surfaces.…”

Section: Introductionmentioning

confidence: 99%

Effect of Silver Nanoparticles, Zinc Oxide Nanoparticles and Titanium Dioxide Nanoparticles on Microshear Bond Strength to Enamel and Dentin

Jowkar

Farpour

Koohpeima

et al. 2018

The Journal of Contemporary Dental Practice

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Aim:This study was aimed to evaluate whether antibacterial pretreatment of enamel and dentin with silver nanoparticles (SNPs), zinc oxide nanoparticles (ZNPs) and titanium dioxide nanoparticles (TNPs) has any effect on the microshear bond strength of an etch-and-rinse adhesive system. Materials and methods:Eighty human third molars were randomly assigned to eight subgroups (n = 10). Enamel groups included no pretreatment (E), pretreatments with SNPs (ESNP), ZNPs (EZNP) and TNPs (ETNP) before acid etching and adhesive application. Dentinal groups included no pretreatment (D), pretreatments with SNPs (DSNP), ZNPs (DZNP) and TNPs (DTNP). The specimens were bonded by Adper Single Bond and polyvinyl chloride microtubes and were restored with Z250 composite. The bonded surfaces underwent microshear bond strength (µSBS) test. Data in megapascal (MPa) were analyzed with the Kruskal-Wallis test and the Mann-Whitney test (p = 0.05). Results:There was not a significant difference among the groups in enamel (p > 0.05). There was no significant difference between the application of three nanoparticles and the control group in dentin. However, DSNPs had a higher µSBS (25.60 ± 14.61) than that of the DZNPs and DTNPs groups (p = 0.03 and p = 0.001, respectively). Also, the mean µSBS value was lower in dentin groups compared to the respective enamel groups (p < 0.05) except for groups DSNPs and ESNPs in which no significant difference was found (p > 0.05). Conclusion:Pretreatment with SNPs, TNPs, and ZNPs can be suggested to achieve potent antibacterial activities without compromising the bond strength. The best result was obtained for pretreatment with SNPs compared to pretreatment with TNPs or ZNPs in dentin and enamel, albeit the differences were not significant in the enamel groups.Clinical significance: Effective antibacterial treatment prior to adhesive bonding application is desirable to provide successful restoration if it would not adversely affect the bond strength of the adhesive system. Nanoparticles can be applied to meet this goal.

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Antibacterial activity of resin composites containing surface pre-reacted glass-ionomer (S-PRG) filler

Cited by 85 publications

References 26 publications

Metal ions from S‐PRG filler have the potential to prevent periodontal disease

Metal ions from S‐PRG filler have the potential to prevent periodontal disease

PMMA denture base material enhancement: a review of fiber, filler, and nanofiller addition

Effect of Silver Nanoparticles, Zinc Oxide Nanoparticles and Titanium Dioxide Nanoparticles on Microshear Bond Strength to Enamel and Dentin

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