Antibacterial Activity of Silver and Its Application in Dentistry, Cardiology and Dermatology

Abstract

The problem of antimicrobial resistance is increasingly present and requires the discovery of new antimicrobial agents. Although the healing features of silver have been recognized since ancient times, silver has not been used due to newly discovered antibiotics. Thanks to technology development, a significant step forward has been made in silver nanoparticles research. Nowadays, silver nanoparticles are a frequent target of researchers to find new and better drugs. Namely, there is a need for silver nanoparticles as alternative antibacterial nanobiotics. Silver nanoparticles (AgNPs), depending on their size and shape, also have different antimicrobial activity. In addition to their apparent antibacterial activity, AgNPs can serve as drug delivery systems and have anti-thrombogenic, anti-platelet, and anti-hypertensive properties. Today they are increasingly used in clinical medicine and dental medicine. This paper presents silver antimicrobial activity and its use in dentistry, cardiology, and dermatology, where it has an extensive range of effects.

Candida albicans—The Virulence Factors and Clinical Manifestations of Infection

“…To conclude, it is worth mentioning traditional topical medications, used additionally in the treatment of cutaneous candidiasis: potassium permanganate (KMnO 4 ), gentian violet solution, Burow’s solution (aluminum acetate) [ 74 ]. Additionally, in the search for novel antifungal preparations, the use of silver has reemerged [ 138 ]. Recently, the effect of silver nanoparticles (AgNPs) on various dermatophytes and yeasts, including Candida spp .…”

Silver Nanoparticles as Carriers of Anticancer Drugs for Efficient Target Treatment of Cancer Cells

“…Silver nanoparticles (AgNPs) have intrinsic antibacterial and anticancer properties, through several mechanisms, like for example, due to silver ions or formation of radical species, released and formed respectively after the AgNPs are up took by the living cells or bacteria, which originates deregulation of important cellular mechanisms, leading to aggravated cellular damage and death. Thus, nowadays, AgNPs are already used often impregnated in antiseptic medical bandages [7], or food containers [8]. The possibility of conjugate the anticancer intrinsic property of AgNPs with the pharmacological effect of anticancer drugs can be the answer for the treatment of tumors that after a time stop responding to chemotherapy or radiotherapy.…”

Antibacterial, Antifungal and Antibiofilm Activities of Silver Nanoparticles Supported by Crude Bioactive Metabolites of Bionanofactories Isolated from Lake Mariout

“…By the virtue of small dimensions (≤100 nm) and high surface to volume ratio, magnetic and catalytic properties of metallic NPs and their oxides, including Ag, Au, Zn, Fe, etc., find their way into distinct bactericidal formulations for different applications such as food packaging, plant disease management, water disinfection and skin care products [12,13]. Recently, the combination of different antibiotics with biogenic metals NPs enhanced their antagonistic performance which is considered an upsurge opportunity to improve adjuvant or combination therapy against multidrug-resistant (MDR) pathogens [14][15][16].…”