Antibacterial activity of silver-carried sodium zirconium phosphate prepared by ion-exchange reaction

Tan, Shaozao; Zhang, Liling; Liu, Yingliang; Shi, Qingshan; Ouyang, Yu; Yi-ben, Chen

doi:10.2109/jcersj2.116.767

Cited by 9 publications

(4 citation statements)

References 17 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…The ciNPT skin interface layer contains an inorganic silver carrier in the form of silver hydrogen zirconium phosphate, which releases Ag + ions during the ionic equilibrium exchange process. 19 The reduction in microbial growth in the presence of such Ag + is consistent with known antimicrobial properties of the silver. 12,20,21 Overall, these results indicate the ability of ionic silver, which is present within the ROCF-ciNPT skin interface layer, to reduce the bioburden within the dressing, which may arise during the negative pressure treatment.…”

Section: Resultssupporting

confidence: 72%

Assessment of Silver Levels in a Closed-Incision Negative Pressure Therapy Dressing: In Vitro and In Vivo Study

Kharkar

Osborne

Stern

et al. 2020

Advances in Wound Care

View full text Add to dashboard Cite

In recent years, reticulated open-cell foam-based closed-incision negative pressure therapy (ROCF-ciNPT) has shown effectiveness in management of various postoperative incisions. These dressings consist of a skin interface layer that absorbs fluid from the skin surface and reduces the potential for microbial colonization within the dressing by means of ionic silver. This study examines the ability of silver to reduce the bioburden within the dressing as well as the localized effect due to potential silver mobility. Approach: Ability of silver to reduce bioburden within the ROCF-ciNPT dressing was assessed using Staphylococcus aureus, Pseudomonas aeruginosa, and Candida spp. Furthermore, silver mobility was assessed using an in vitro skin model to study the zone of inhibition along with released silver quantification. Using a porcine model, diffusion of silver into blood and tissue was studied using emission spectrometry and histology. Results: Microbial growth in the ROCF-ciNPT dressing was significantly reduced (*2.7-4.9 log reduction) compared to a silver-free negative control. No zone of inhibition was observed for microbial colonies for up to 7 days with minimal localized silver release (<5.5 ppm release). In vivo studies demonstrated no measurable concentration (<0.2 lg/g) of silver in the blood, urine, feces, kidney, and liver tissue biopsy. Innovation: This study provides an important insight into silver concentration and mobility within the ROCF-ciNPT dressing, given emerging concerns associated with potential silver cytotoxicity. Conclusion: These results indicate the concentration of silver (0.019% silver by weight) in the ROCF-ciNPT dressings has been adequate to reduce bioburden within the skin interface layer, while severely limiting the amount of silver leaching out.

show abstract

Section: Resultssupporting

confidence: 72%

Assessment of Silver Levels in a Closed-Incision Negative Pressure Therapy Dressing: In Vitro and In Vivo Study

Kharkar

Osborne

Stern

et al. 2020

Advances in Wound Care

View full text Add to dashboard Cite

show abstract

“…The AFE values oscillating around 100% after storage suggest that the obtained effect would be maintained for the composites also in the case of extended aging time. Antimicrobial action of the used filler based on ion exchange of cations from the environment (e.g., Na + , Ca 2+ ) with silver from the insoluble, inorganic carrier, but a controlled release of silver ions is activated under wet conditions [44] so dry samples do not show an antimicrobial effect. The release of silver can eliminate bacteria by varied mechanisms such as a reaction with the peptidoglycan component of the bacterial cell wall causing their puncture, disruption of cellular respiration and metabolic pathways after its penetration into cells, causing the creation of reactive oxygen species due to the disrupted DNA and its replication cycle [45].…”

Section: Discussionmentioning

confidence: 99%

A Temporary Acrylic Soft Denture Lining Material Enriched with Silver-Releasing Filler-Cytotoxicity, Mechanical and Antifungal Properties

Chladek,

Kalamarz,

Pakieła

et al. 2024

Materials

View full text Add to dashboard Cite

Colonization of temporary denture soft linings and underlying tissues by yeast-like fungi is an important clinical problem due to the negative influence on the process of prosthetic treatment. Typical hygienic procedures are often insufficient to prevent fungal infections, so in this study, an antimicrobial filler (silver sodium hydrogen zirconium phosphate) was introduced into acrylic soft liner at concentrations of 1, 2, 4, 6, 8 and 10% (w/w). The effect of this modification on antifungal properties against Candida albicans, cytotoxicity, Shore A hardness, tensile strength and tensile bond strength, sorption and solubility was investigated, considering the recommended 30-day period of temporary soft lining use. The most favorable compilation of properties was obtained at a 1 to 6% filler content, for which nearly a total reduction in Candida albicans was registered even after 30 days of sample storing. The tensile and bond strength of these composites was at the desired and stable level and did not differ from the results for the control material. Hardness increased with the increasing concentration in filler but were within the range typical for soft lining materials and their changes during the experiment were similar to the control material. The materials were not cytotoxic and sorption and solubility levels were stable.

show abstract

“…Sodium hypochlorite Low toxicity profile (medical disinfection), wide range anti-microbial properties, cheap [5,6] Skin irritation, swelling, rash, pain, corrosive [7,8] 2 years [9,10] +++ 0.5% [9,11,12] Silver ion Low toxicity profile, Potent antimicrobial agent [13][14][15][16][17] Argyria, silver dermatitis, interrupt drug absorption [18][19][20][21] At least 7 months [22] ++ 0.01% [23] Iodophor Wide range of antimicrobial, Stable storage, Low toxicity profile [24] Chemical burn, Blistering, Skin sloughing [25] 2 years [4,26] ++++ 1% at 6 to 75 ppm [27][28][29][30] Glycol Wide range of anti-microbial, Low toxicity profile [31,32] lower microbial killing strength, Sensory skin irritation [33,34,35] 2 years [36] + <0.5% ( insufficient data) [33] mg/L of AgZrP for 8 hours, complete elimination of E. coli and 99.9% of S. aureus is possible [50] . Another compound, silver zeolite at concentrations above 375 mg/L was reported to be effective in complete inactivation of both SARS-CoV-P8 and SARS-CoV-P11 strains of coronavirus within 2 hours [17] .…”

Section: Disinfectantmentioning

confidence: 99%

COVID 19: The safety profile of common disinfectants used for sanitization

Chooi¹,

Yee²

2020

Prog Drug Discov Biomed Sci

View full text Add to dashboard Cite

With the recent outbreak of COVID-19, sanitization is a must for the community as daily safety prevention. The common ingredients found in disinfectant including glycol, sodium hypochlorite, silver ion, iodophor iodine and polyvinyl-pyrrolidone iodine. An ideal disinfectant should have a wide anti-microbial spectrum, low dermatologically toxicity profile, and stable storage properties. Glycol is widely used as a personal care product due to its low toxicity profile. Although it has a wide anti-microbial spectrum, it must be co-formulated with other agent due to its lower microbial killing strength. It has been demonstrated that sodium hypochlorite is not only capable of destroying bacteria and viruses but also about inactivating viral antigens by breaking down the high concentration protein resulting in the isolation of necrotic tissue particles. Yet, due to its strong alkaline pH and oxidizing capacity, it can cause corrosive reaction when mucous membranes and skin are in touch with it. Besides, silver ion also plays an effective role in curbing SARS coronavirus. It is used widely in disinfecting medical equipment, wound therapy, and utilized in water purification systems by its bacteriostatic and active ingredient properties. Researches have proven that iodophor iodine is effective in against non-enveloped virus in which 1% of povidone-iodine is effective against coronaviruses. However, it can cause a chemical burn, blistering, and skin sloughing if it used as skin disinfection. This report will discuss the safety of these disinfectants in sanitization.

show abstract

Antibacterial activity of silver-carried sodium zirconium phosphate prepared by ion-exchange reaction

Cited by 9 publications

References 17 publications

Assessment of Silver Levels in a Closed-Incision Negative Pressure Therapy Dressing: In Vitro and In Vivo Study

Assessment of Silver Levels in a Closed-Incision Negative Pressure Therapy Dressing: In Vitro and In Vivo Study

A Temporary Acrylic Soft Denture Lining Material Enriched with Silver-Releasing Filler-Cytotoxicity, Mechanical and Antifungal Properties

COVID 19: The safety profile of common disinfectants used for sanitization

Contact Info

Product

Resources

About