Antibacterial Activity of Substituted 1,3-Dioxolanes

Ovsyannikova, M. N.; Вольева, В. Б.; Belostotskaya, I. S.; Комиссарова, Н. Л.; Малкова, А. В.; Kurkovskaya, L. N.

doi:10.1007/s11094-013-0913-6

Cited by 16 publications

(7 citation statements)

References 4 publications

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“…The compounds identified in this plant have been reported previously with significant biological activities. Cyclohexanone possess strong antibacterial activity [ 57 ]. Red and white wine containing succinic acid have been reported with strong antibacterial activity [ 58 ].…”

Section: Discussionmentioning

confidence: 99%

Demonstration of biological activities of extracts from Isodon rugosus Wall. Ex Benth: Separation and identification of bioactive phytoconstituents by GC-MS analysis in the ethyl acetate extract

Zeb

Ullah

Ayaz

et al. 2017

BMC Complement Altern Med

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BackgroundSince long, natural sources have been explored for possible managements of various diseases. In this context, the study is designed to evaluate Isodon rugosus Wall. ex Benth for biological potentials including antibacterial, anthelmintic, insecticidal, anti-termites and anti-Pharaoh activities followed by GC-MS analysis of active fraction to identify various bioactive compounds.Methods I. rugosus was investigated against eight bacterial strains using well diffusion method and microdilution method with ceftriaxone as positive control. Similarly, the insecticidal activity was carried out against Tribolium castaneum, Rhyzopertha dominica, Monomorium pharaonis and Heterotermis indicola following contact toxicity method. Likewise, anthelmintic activity was performed against Ascaridia galli and Pherethima posthuma using albendazole as positive control, in which the paralysis and death times of the worms were observed. The GC-MS analysis of the most active solvent fraction was performed for identifications of various bioactive compounds.ResultsAmong the tested samples of I. rugosus, flavonoids and ethyl acetate fraction exhibited high antibacterial activities. The crude saponins showed highest anthelmintic activity against Pherethima posthuma and Ascaridia galli with death times of 27.67 and 29.22 min respectively at concentrations of 40 mg/ml. In insecticidal activity, chloroform fraction and saponins exhibited notable results against R. dominica (60 and 70%) and T. castaneum (70 and 76%) at concentration of 200 mg/ml. In anti-termite assay, all the plant samples showed overwhelming results, i.e. all the 25 termites were killed on the 3rd day. Similarly, in anti-Pharaoh activity, the chloroform, ethyl acetate and saponins fractions were most potent, each exhibiting LD50 of <0.1 mg/ml. In GC-MS analysis, total of 57 compounds were identified. Some of the bioactive compounds identified in GC-MS analysis are palmitic acid, hinokiol, α-amyrin, phytol, ethyl linolate, cyclohexanone, hinokione, methyl palmitate, ethyl palmitate and stigmasterol acetate.ConclusionsBased on our current results, it can be concluded that I. rugosus possess strong antibacterial, insecticidal and anthelmintic potentials having crude saponins and ethyl acetate as the most active fractions. The GC-MS analysis and biological assays reveal that ethyl acetate fraction is a suitable target for the isolation of diverse array of bioactive compounds.

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Section: Discussionmentioning

confidence: 99%

Demonstration of biological activities of extracts from Isodon rugosus Wall. Ex Benth: Separation and identification of bioactive phytoconstituents by GC-MS analysis in the ethyl acetate extract

Zeb

Ullah

Ayaz

et al. 2017

BMC Complement Altern Med

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“…A reference sample of acetal formed by the reaction of acetaldehyde with glycerol (a mixture of isomers 3 and 4) was synthesized according to the procedure described in [6]; bp 78-79°C (5 mm). 1 A reference sample of dioxolane 1 was prepared by transesterification of rapeseed oil with an equivalent amount of dioxolane 2 in the presence of sodium hydroxide (1 wt %) under stirring at 80°C.…”

Section: Methodsmentioning

confidence: 99%

Synthesis of biodiesel without formation of free glycerol

et al. 2015

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A new approach to the synthesis of biodiesel has been developed on the basis of alcoholysis of a triglyceride in combination with acetalization of glycerol with lower carbonyl compounds or acetals derived therefrom. A model synthesis of biodiesel not involving free glycerol has been accomplished using rapeseed oil and acid catalysts, as well as without a catalyst under generation of ethanol supercritical fluid; in the latter case, monoalkyl glycerol ethers are formed in addition to the expected cyclic ketals.

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“…In river water, no removal was seen with any of the PACs even at the highest doses. The two oxygen atoms in the dioxolane ring confer hydrophilic character on the compound when the ring does not have any substitutions, which is the case in EMD, making PAC unsuitable for its removal (Ovsyannikova et al, 2013).…”

Section: Alcohols and Estersmentioning

confidence: 99%

Treatability of 18 taste and odor compounds using powdered activated carbon in drinking water utilities

et al. 2022

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Taste and odor (T&O) compounds in source waters can enter drinking water utilities causing customer concerns about the water quality if not removed during treatment. While there has been extensive research on two common T&O compounds, 2-methylisoborneol (2-MIB) and geosmin, research on non-MIB/ geosmin compounds has been limited. This study evaluated the treatability of 16 non-MIB/geosmin compounds, 2-MIB, and geosmin using powdered activated carbon (PAC). Four types of PAC were tested: two bituminous-based, one lignite-based, and one wood-based PAC. Among the 18 compounds, PAC was effective for 15 compounds with at least 90% removal with typical PAC dosing, but was not suitable for dimethyl disulfide, ethyl methyl dioxolane, and cis-3-hexenol. The bituminous-based PACs showed greater removal with higher adsorption rates compared to the lignite-and wood-based PACs. The adsorption behavior of T&O compounds varied based on their physical and chemical characteristics, for example, hydrophobicity, and nature of functional groups.

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Antibacterial Activity of Substituted 1,3-Dioxolanes

Cited by 16 publications

References 4 publications

Demonstration of biological activities of extracts from Isodon rugosus Wall. Ex Benth: Separation and identification of bioactive phytoconstituents by GC-MS analysis in the ethyl acetate extract

Demonstration of biological activities of extracts from Isodon rugosus Wall. Ex Benth: Separation and identification of bioactive phytoconstituents by GC-MS analysis in the ethyl acetate extract

Synthesis of biodiesel without formation of free glycerol

Treatability of 18 taste and odor compounds using powdered activated carbon in drinking water utilities

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