Antibacterial Activity of Thioetherhydroxyethylsulfonamide Derivatives

Abstract

Thioetherhydroxyethylsulfonamide derivatives were synthesized and evaluated for their in vitro antibacterial activity against Escherichia coli (ATCC 25922), Pseudomonas aeruginosa (ATCC 27853) and Staphylococcus aureus (ATCC 25923). Results have shown that compounds 8c and 9e display potent activity (MIC = 0.125 µg/mL) against E. coli when compared with the standard drug sulfamethoxazole (SMZ, MIC < 0.5 µg/mL) for this same strain. All the new compounds were fully identified and characterized by NMR ((1)H and (13)C) and X-ray crystallography (for compound 8c). This class of compounds can be considered as a good starting point for the development of new lead molecules in the fight against multi-drug bacterial resistance.

Regioselective reaction of imidazole-2-thiols with N-sulfonylphenyldichloroacetaldimines: en route to novel sulfonylamino-substituted imidazo[2,1-b]thiazoles and thiazolo[3,2-a]benzimidazoles

“…[29][30][31][32] First of all, these are medicinally classical antagonists of folic acid having antimicrobial and antibiotic properties. [29][30][31][32][33][34] Also, we should take note of sulfonamides exerting antitumor [35][36][37] and anti-inflammatory activity, 38,39 neuroleptics, 40 anticonvulsants, diuretics, analgetics and antimigraine remedies. 41 Among sulfonamides there are efficient inhibitors of proteases, 41,42 COX-2 [43][44][45][46][47] and caspase inhibitors 48,49 associated with different diseases.…”