Antibacterial activity of Thymus maroccanus and Thymus broussonetii essential oils against nosocomial infection – bacteria and their synergistic potential with antibiotics

Fadli, Mariam; Saad, Asmaa; Sayadi, Sami; Chevalier, Jacqueline; Mezrioui, Nour-Eddine; Pagès, Jean‐Marie; Hassani, Lahcen

doi:10.1016/j.phymed.2011.12.003

Cited by 199 publications

(139 citation statements)

References 38 publications

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“…Many mechanisms pathways of essential oil/antibiotics synergism include sequential inhibition of common biochemical pathways, inhibition of protective enzymes, combination of membrane active agents, and use of membranotropic agents, these mechanisms leads to enhance the diffusion of other antimicrobials [44][45][46][47]. In addition, recent studies have demonstrated that some plant compounds can effectively inhibit the efflux pumps involved in antibiotic resistance mechanisms [48], which could lead to the restoration of sensitivity to antibiotics and reduce their minimum effective dose and thus their side effects and residues in animal products.…”

Section: Discussionmentioning

confidence: 99%

Antibacterial Activity of Mentha Pulegium Essential Oil Against Avian Isolated Esbl Producing Bacteria and Its Synergistic Potential With Antibiotics

Yahiaoui

Benameur

Ben-Mahdi

2017

Int J Pharm Pharm Sci

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Objective: The aim of this study was to evaluate the antibacterial effect of Algerian Mentha pulegium essential oil against extended-spectrum β-lactamases (ESBL) producing bacteria isolated from avian livestock. The synergistic interactions between conventional antibiotics and Mentha pulegium essential oil were assessed. Methods:Essential oil composition was determined by gas chromatograph-flame ionization detector (GC/FID), gas chromatograph-mass spectrometer (GC/MS) analysis.Antibacterial activity of Mentha pulegium essential oil against ESBL producing bacteria was investigated by disc diffusion assay. Minimum inhibitory concentration (MIC) of essential oil and it synergistic interaction with conventional antibiotics were determined by micro-broth dilution method and checkerboard test, respectively. Results:The results indicate that Mentha pulegium essential oil with a high amount of pulegone (88.78%) had high inhibitory activity against the tested strains and particularly displays a satisfactory action against the studied ESBL producing bacteria from animal origin, with a diameter ranging from 13 to 26 mm. Out of 51 combinations tested between essential oil and antibiotics 60.78 % showed total synergy, 13.72 % had presented a partial synergy. The best antibacterial activities were obtained with the combination of Mentha pulegium essential oil and cefazolin, cefotaxime and gentamycin. Conclusion:This study allowed concluding that Mentha pulegium essential oil showed not only satisfactory antibacterial properties, but also acts synergistically combined with conventional antibiotics, which make it a promising alternative to antimicrobial drugs; beside that, it might reduce the minimum effective dose of the drugs which minimizes their possible side effects.

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Section: Discussionmentioning

confidence: 99%

Antibacterial Activity of Mentha Pulegium Essential Oil Against Avian Isolated Esbl Producing Bacteria and Its Synergistic Potential With Antibiotics

Yahiaoui

Benameur

Ben-Mahdi

2017

Int J Pharm Pharm Sci

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“…For example, it has been noted that carvacrol showed a synergistic effect when combined with ciprofloxacin [20]. Moreover, this alternative strategy could be interesting because it can ideally lead to a reduction of doses of the antibiotics, thus reducing the adverse effects of the therapy.…”

Section: Discussionmentioning

confidence: 99%

In VitroAntibacterial Activity of Essential Oils againstStreptococcus pyogenes

Sfeir

Lefrançois

Baudoux³

et al. 2013

Evidence-Based Complementary and Alternative Medicine

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Streptococcus pyogenes plays an important role in the pathogenesis of tonsillitis. The present study was conducted to evaluate the in vitro antibacterial activities of 18 essential oils chemotypes from aromatic medicinal plants against S. pyogenes. Antibacterial activity of essential oils was investigated using disc diffusion method. Minimum Inhibitory Concentration of essential oils showing an important antibacterial activity was measured using broth dilution method. Out of 18 essential oils tested, 14 showed antibacterial activity against S. pyogenes. Among them Cinnamomum verum, Cymbopogon citratus, Thymus vulgaris CT thymol, Origanum compactum, and Satureja montana essential oils exhibited significant antibacterial activity. The in vitro results reported here suggest that, for patients suffering from bacterial throat infections, if aromatherapy is used, these essential oils, considered as potential antimicrobial agents, should be preferred.

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“…All these mechanisms may be responsible for the coagulation of inner cellular components in the cytoplasm and break down of the bonds between the lipid and protein layers (Burt, 2004). The lipophilicity of essential oils enables them to preferentially partition from an aqueous phase into membrane structures of the fungi, resulting in membrane expansion, increased membrane fluidity and permeability, disturbance of membrane-embedded proteins, inhibition of respiration, disintegration of mitochondrial membranes, alteration of ion transport processes in fungi and leakage of ions and other cellular contents (Fadli et al, 2012 andAleksic &Knezevic, 2014).…”

Section: Discussionmentioning

confidence: 99%

Potential Activity of Some Essential Oils and Human Amniotic Membrane against Malassezia furfur and Staphylococcus aureus Isolated from Pityriasis Versicolor Patients

2018

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Antibacterial activity of Thymus maroccanus and Thymus broussonetii essential oils against nosocomial infection – bacteria and their synergistic potential with antibiotics

Cited by 199 publications

References 38 publications

Antibacterial Activity of Mentha Pulegium Essential Oil Against Avian Isolated Esbl Producing Bacteria and Its Synergistic Potential With Antibiotics

Antibacterial Activity of Mentha Pulegium Essential Oil Against Avian Isolated Esbl Producing Bacteria and Its Synergistic Potential With Antibiotics

In VitroAntibacterial Activity of Essential Oils againstStreptococcus pyogenes

Potential Activity of Some Essential Oils and Human Amniotic Membrane against Malassezia furfur and Staphylococcus aureus Isolated from Pityriasis Versicolor Patients

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