Antibacterial activity, surface roughness, flexural strength, and solubility of conventional luting cements containing chlorhexidine diacetate/cetrimide mixtures

Korkmaz, Fatih; Tüzüner, Tamer; Baygın, Özgül; Buruk, Celal Kurtuluş; Durkan, Rukiye; Bağış, Bora

doi:10.1016/s0022-3913(13)60349-2

Cited by 31 publications

(23 citation statements)

References 41 publications

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“…For some formulations, a limited deterioration in mechanical properties was observed. CHX digluconate solution has also been incorporated into GICs in combination with another antimicrobial agent, cetrimide, and this too had an antimicrobial effect on oral bacteria [16]. The authors indicate that this effect persisted for up to 180 days, but whether this was due to antimicrobial still leaching at the 180 day point, or that which had earlier leached and was still present in the agar plate, is not clear.…”

Section: Resultsmentioning

confidence: 99%

Development of a novel antimicrobial-releasing glass ionomer cement functionalized with chlorhexidine hexametaphosphate nanoparticles

et al. 2014

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BackgroundGlass ionomer cements (GICs) are a class of dental biomaterials. They have a wide range of uses including permanent restorations (fillings), cavity linings, fissure sealants and adhesives. One of the most common reasons for replacing a dental restoration is recurrent bacterial tooth decay around the margins of the biomaterial. Therefore, a dental biomaterial which creates a sustained antimicrobial environment around the restoration would be of considerable clinical benefit. In this manuscript, the formulation of a GIC containing novel antimicrobial nanoparticles composed of chlorhexidine hexametaphosphate at 1, 2, 5, 10 and 20% powder substitution by mass is reported. The aim is to create GICs which contain chlorhexidine-hexametaphosphate nanoparticles and characterize the nanoparticle size, morphology and charge and the release of chlorhexidine and fluoride, tensile strength and morphology of the GICs.ResultsThe GICs released chlorhexidine, which is a broad spectrum antimicrobial agent effective against a wide range of oral bacteria, over the duration of the experiment in a dose-dependent manner. This was not at the expense of other properties; fluoride release was not significantly affected by the substitution of antimicrobial nanoparticles in most formulations and internal structure appeared unaffected up to and including 10% substitution. Diametral tensile strength decreased numerically with substitutions of 10 and 20% nanoparticles but this difference was not statistically significant.ConclusionA series of GICs functionalized with chlorhexidine-hexametaphosphate nanoparticles were created for the first time. These released chlorhexidine in a dose-dependent manner. These materials may find application in the development of a new generation of antimicrobial dental nanomaterials.

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Section: Resultsmentioning

confidence: 99%

Development of a novel antimicrobial-releasing glass ionomer cement functionalized with chlorhexidine hexametaphosphate nanoparticles

et al. 2014

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“…It is fundamental to consider that propolis, a natural resin-like material, and silica particles are primarily focused on the context of increasing material strength, but this focus should not compromise other properties. Additionally, the addition of 2.5% of chlorhexidine diacetate with 2.5% of cetrimide yielded an increased solubility of GIC (Korkmaz et al 2013). Therefore, since the result of the chemical reaction of the GIC with theobromine did not change the sorption and solubility of the material, if sufficient additional properties are not compromised, its use could be considered safe.…”

Section: Discussionmentioning

confidence: 99%

Effects of theobromine addition on chemical and mechanical properties of a conventional glass ionomer cement

et al. 2019

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In vitro effect of 1% theobromine addition on the physical and chemical properties of conventional glass ionomer (GIC) cement was investigated. Conventional GIC (GIC-C) and 1% theobromine added to GIC (GIC-THEO) specimens were compared regarding the microhardness (n = 10), sorption (n = 5), solubility (n = 5), color change (n = 10), fluoride release in saliva (n = 10) and the amount of biofilm deposition (n = 20). Compared against conventional GIC, adding 1% theobromine increased microhardness (p < 0.05), while its sorption, solubility, color and fluoride release to saliva (p > 0.05) remained unchanged. On the other hand, Streptococcus mutans biofilm amount deposited on its surface decreased statistically when theobromine was added to GIC (p < 0.05). Based on the results, it could be concluded that 1% theobromine addition to GIC can be a good strategy as it keeps some of its properties and improves microhardness and biofilm deposits strengthening its role in the preventive approach of dentistry.

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“…: -implants 97) , pulp capping materials 98) , Transbond XT 99) , pit and fissure sealing 100) , cavity disinfectant 101) , resin cement 102), zinc phosphate cement, and zinc polycarboxylate cement 103) . These studies have shown that QACs possess antimicrobial activities against bacteria and fungi including S. mutans, L. acidophilus, C. albicans, E. faecalis ect.…”

Section: Discussionmentioning

confidence: 99%

Quaternary ammonium compounds in dental restorative materials

Zhang

Chen

et al. 2018

Dental Materials Journal

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Quaternary ammonium compounds (QACs) have been used widely in medicine, owing to their antimicrobial properties. They also have strong permeability, stable performance, low skin irritation, low toxicity, low corrosion, lasting biological effects and so on, comparing with other antimicrobial agents. At the end of last century, polymerizable quaternary ammonium antimicrobial monomers had been synthesized and applied in dentistry, in order to reduce or prevent microbial biofilm formation on dental materials surfaces. This review aims to discuss the current progress of QACs applied in composite resin, adhesive systems, acrylic resin, glass ionomer cement and endodontic materials, regarding to their antimicrobial potential, mechanical properties, and biocompatibility.

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Antibacterial activity, surface roughness, flexural strength, and solubility of conventional luting cements containing chlorhexidine diacetate/cetrimide mixtures

Cited by 31 publications

References 41 publications

Development of a novel antimicrobial-releasing glass ionomer cement functionalized with chlorhexidine hexametaphosphate nanoparticles

Development of a novel antimicrobial-releasing glass ionomer cement functionalized with chlorhexidine hexametaphosphate nanoparticles

Effects of theobromine addition on chemical and mechanical properties of a conventional glass ionomer cement

Quaternary ammonium compounds in dental restorative materials

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