2001
DOI: 10.1271/bbb.65.2306
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Antibacterial Agents that Inhibit Histidine Protein Kinase YycG of Bacillus subtilis

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Cited by 64 publications
(45 citation statements)
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“…[4][5][6][7][8] As such, the WalK/WalR system constitutes an attractive target for the development of novel antimicrobial compounds, as inhibitors targeting WalK or WalR would be expected to have a bactericidal effect toward a broad range of major Grampositive pathogens. Previously, a number of HK inhibitors have been identified, [9][10][11][12] but these studies did not conclusively show a direct relationship between cell death and HK inhibition rather than some other uncharacterized nonspecific effect. However, structure-based virtual screening of compounds potentially targeting the kinase activity of S. epidermidis WalK found several to be active against not only S. epidermidis but also S. aureus, S. aureus and S. mutans.…”
Section: Introductionmentioning
confidence: 99%
“…[4][5][6][7][8] As such, the WalK/WalR system constitutes an attractive target for the development of novel antimicrobial compounds, as inhibitors targeting WalK or WalR would be expected to have a bactericidal effect toward a broad range of major Grampositive pathogens. Previously, a number of HK inhibitors have been identified, [9][10][11][12] but these studies did not conclusively show a direct relationship between cell death and HK inhibition rather than some other uncharacterized nonspecific effect. However, structure-based virtual screening of compounds potentially targeting the kinase activity of S. epidermidis WalK found several to be active against not only S. epidermidis but also S. aureus, S. aureus and S. mutans.…”
Section: Introductionmentioning
confidence: 99%
“…Walkmycin B was concentrated in vacuo to give 99.7 mg of brownish yellow oil. The crude oil was further purified by crystallization in a mixture solvent of 13 C NMR, and physico-chemical properties of walkmycin B were very similar to those of BE40665 A. 23 As walkmycin B is not stable in DMSO and acetone, we could not compare the chemical shifts of 1 H, 13 C NMR and the specific rotation of walkmycin B with those of BE40665 A.…”
Section: Purification Of Walkmycin Bmentioning
confidence: 99%
“…The crude oil was further purified by crystallization in a mixture solvent of 13 C NMR, and physico-chemical properties of walkmycin B were very similar to those of BE40665 A. 23 As walkmycin B is not stable in DMSO and acetone, we could not compare the chemical shifts of 1 H, 13 C NMR and the specific rotation of walkmycin B with those of BE40665 A. However, a series of two-dimensional NMR and nuclear overhauser enhancement spectroscopy analyses indicated the structure of BE40665 A.…”
Section: Purification Of Walkmycin Bmentioning
confidence: 99%
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