Antibacterial and antibiotic resistance modulatory activities of leaves and bark extracts of Recinodindron heudelotii (Euphorbiaceae) against multidrug-resistant Gram-negative bacteria

Fankam, Aimé G.; Kuiaté, Jules Roger; Kuete, Victor

doi:10.1186/s12906-017-1687-2

Cited by 34 publications

(29 citation statements)

References 26 publications

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“…African medicinal plants have previously shown efficiency against MDR bacteria with some of them being able to modulate the activity of antibiotics. Some of these plants include Xanthosoma mafaffa, Moringa oleifera, Passiflora edulis [ 5 ], Anthocleista schweinfurthii, Nauclea latifolia, Zehneria scabra [ 6 ], Nauclea pobeguinii [ 7 ], Catharanthus roseus, Croton macrostachys, Paullinia pinnata [ 8 ], Albizia adianthifolia, Alchornea laxiflora, Laportea ovalifolia [ 9 ], Mangifera indica [ 10 ], Ricinodendron heudelotii [ 11 ], and Euphorbia prostrata [ 12 ]. In our continuous search for new botanicals to combat MDR bacteria as well as potentiate the activity of antibiotics, we targeted another African plant, Syzygium jambos (L.) Alston.…”

Section: Introductionmentioning

confidence: 99%

Syzygium jambos Displayed Antibacterial and Antibiotic‐Modulating Activities against Resistant Phenotypes

Wamba

Nayim

Mbaveng

et al. 2018

Evidence-Based Complementary and Alternative Medicine

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The present study was designed to evaluate the antibacterial activities of methanol extracts of bark and leaves of Syzygium jambos, as well as their synergistic effects with selected antibiotics against drug-resistant Gram-positive and Gram-negative bacteria. The crude extracts were subjected to qualitative phytochemical screening; broth microdilution method was used for antibacterial assays. Phytochemical studies indicate that leaves and bark extracts contained polyphenols, anthraquinones, tannins, and steroids. Extract of the leaves was active against all the 26 strains of Staphylococcus aureus and all the 21 strains of Gram-negative bacteria tested, within the minimum inhibitory concentration (MIC) range of 32–512 μg/mL. The lowest MIC value of 32 μg/mL was obtained with extract of the leaves against Staphylococcus aureus MRSA9 strain. In Gram-negative bacteria, the lowest MIC value of 64 μg/mL was also obtained against Enterobacter aerogenes EA294 and Klebsiella pneumoniae K24 strains. Against S. aureus strains, antibiotic-modulating activity of extracts at MIC/2 towards more than 70% of the tested strains was obtained when leaves and bark extracts were tested in association with chloramphenicol (CHL). This was also the case when leaves extract was combined with CHL, kanamycin (KAN), tetracycline (TET), and erythromycin (ERY) and when bark extract was combined with ciprofloxacin (CIP), TET, and ERY against Gram-negative bacteria. In conclusion, this study demonstrated that Syzygium jambos has antibacterial and antibiotic-modulating activities.

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Section: Introductionmentioning

confidence: 99%

Syzygium jambos Displayed Antibacterial and Antibiotic‐Modulating Activities against Resistant Phenotypes

Wamba

Nayim

Mbaveng

et al. 2018

Evidence-Based Complementary and Alternative Medicine

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“…Numerous studies were performed exploring antibiotic modulatory activities of many plant materials and a number of promising antibiotic and plant extract combinations were found (Olajuyigbe and Afolayan, 2012;Fankam et al 2015Fankam et al , 2017Morais et al 2017;Sales et al 2017;Nayim et al 2018). However, antibiotic modulatory activity of A. eupatoria, H. alpestre, R. obtusifolius and S. officinalis was shown for the first time.…”

Section: Discussionmentioning

confidence: 99%

Novel approach to combat antibiotic resistance: evaluation of some Armenian herb crude extracts for their antibiotic modulatory and antiviral properties

Ginovyan

Trchоunian

2019

J of Applied Microbiology

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Aims One of the strategies to combat antibiotic resistance can be the use of plant materials in combination with antibiotics, taking into account that phytochemicals can act as antibiotic resistance‐modifying agents. This can give a second life to the traditional antibiotics. The aim was to evaluate antibiotic modulatory effect of crude extracts from Agrimonia eupatoria, Hypericum alpestre, Rumex obtusifolius and Sanguisorba officinalis herbs towards several commercial antibiotics using some Gram‐positive and Gram‐negative bacteria. Methods The antibiotic modulatory activity was tested by determining MICs of antibiotics in the absence and presence of plant crude extracts at subinhibitory concentrations. Antiviral potential of different extracts of tested plant materials was also explored by double overlay plaque assay. Results The tested plant crude extracts exhibited high modulatory activity towards used antibiotics. Particularly, high modulatory activity was observed with extracts of H. alpestre and R. obtusifolius. Many plant‐antibiotic combinations induced the decrease in MICs of antibiotics up to ~fourfold indicating synergy. Moreover, the similar change was observed at both subinhibitory concentrations (MIC/2 and MIC/4) of the same plant crude extract. High anti‐phage activity of plants with the exception of Lilium armenum against T4 phage of Escherichia coli C‐T4 was also shown. Conclusions Plant crude extract or commercial antibiotic combinations significantly increased the efficiency of antibiotics. Tested plant materials with exception of L. armenum have antiviral property. Significance and Impact of the Study For the first time, antibiotic modulatory activity of tested herb extracts was shown, which could have potential in practical applications. Tested plant materials with exception of L. armenum could have prospective, as a source of new antiviral compounds.

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“…The resistance modifying activity of the extracts was evaluated by determining the MICs of antibiotics in the presence or absence of the plant extracts in the 96-wells modulation assay as previously described [ 13 , 25 ]. Briefly, after serial dilutions of antibiotics (256–0.5 μ g/mL), the plant extracts were added at their subinhibitory concentrations (MIC/2 and MIC/4) selected after preliminary study assessed against P. aeruginosa PA124 (Supplementary Materials, Table S3 ).…”

Section: Methodsmentioning

confidence: 99%

Antibacterial and Antibiotic-Potentiating Activities of Thirteen Cameroonian Edible Plants against Gram-Negative Resistant Phenotypes

Nayim

Mbaveng

Wamba

et al. 2018

The Scientific World Journal

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This work was designed to investigate the antibacterial activities of methanol extracts from thirteen Cameroonian edible plants and their antibiotic-potentiating effects against Gram-negative multidrug-resistant (MDR) phenotypes. The broth microdilution method was used to evaluate the minimal inhibitory concentration (MIC) and minimal bactericidal concentration (MBC) of the extracts, as well as their antibiotic-potentiating activities. The phytochemical screening of the extracts was carried out according to the standard methods. The results of phytochemical tests revealed the presence of sterols, polyphenols, and tannins in most of the tested extracts, with the other classes of secondary metabolites being selectively distributed. Tested extracts showed variable antibacterial activities with MIC values ranging from 64 to 1024 μg/mL. However, some extracts were significantly active against certain bacterial strains: seeds extract of Theobroma cacao (64 μg/mL) against Escherichia coli AG100Atet and Klebsiella pneumoniae K24, and the bark extract of Uapaca guineensis against E. coli ATCC 8739. The leaves extract of T. cacao displayed the best MBC values (256 μg/mL) against E. aerogenes EA27. Some tested extracts included extracts from the leaves of T. cacao and P. vulgaris, and the seeds of D. edulis and barks A. indica has selectively improved (2- to 64-fold) the antibacterial activities of some of the tested antibiotics, chloramphenicol (CHL), tetracycline (TET), kanamycin (KAN), streptomycin (STR), and erythromycin (ERY), against more than 70% of tested MDR bacteria. The findings of this work showed that tested plant extracts and particularly those from T. cacao and Phaseolus vulgaris can be used alone or in combination with conventional antibiotics in the treatment of infections involving multiresistant bacteria.

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Antibacterial and antibiotic resistance modulatory activities of leaves and bark extracts of Recinodindron heudelotii (Euphorbiaceae) against multidrug-resistant Gram-negative bacteria

Cited by 34 publications

References 26 publications

Syzygium jambos Displayed Antibacterial and Antibiotic‐Modulating Activities against Resistant Phenotypes

Syzygium jambos Displayed Antibacterial and Antibiotic‐Modulating Activities against Resistant Phenotypes

Novel approach to combat antibiotic resistance: evaluation of some Armenian herb crude extracts for their antibiotic modulatory and antiviral properties

Antibacterial and Antibiotic-Potentiating Activities of Thirteen Cameroonian Edible Plants against Gram-Negative Resistant Phenotypes

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