Antibacterial and antifungal activities in vitro of a novel silver(I) complex with sulfadoxine-salicylaldehyde Schiff base

Oliveira, Igor Santos; Manzano, Carlos Marrote; Nakahata, Douglas Hideki; Santiago, Mariana Brentini; Silva, Nagela Bernadelli Sousa; Martins, Carlos Henrique Gomes; Respíndula, Fernando Pimentel; Pereira, Douglas Henrique; Corbi, Pedro P.

doi:10.1016/j.poly.2022.116073

Cited by 11 publications

(1 citation statement)

References 58 publications

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“…The pure mafenide spectrum showed the presence of (N-H) stretching, which appeared at wave number 3550-3000 cm-1, (N-H) bending at 1542 cm-1, CH2 appeared at 1413 cm-1, carbon-nitrogen group appeared at 1319 cm-1, and sulphonamide group appeared at 1090 cm-1 [30].…”

Section: Fourier Transform Infrared Spectroscopy Analysismentioning

confidence: 99%

Preparation and Justification of Nanofibres-Loaded Mafenide Using Electrospinning Technique to Control Release

R. ATIYAH,

AL-EDRESI

2024

Int J App Pharm

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Objective: The primary objective was to fabricate a novel drug delivery system capable of providing a controlled and prolonged release of antibiotics. Methods: The experimental design was formulated using Design-Expert® software (version 13), enabling systematic and efficient fabrication process optimization. The study involved the preparation of various nanofiber formulations with different ratios of the three polymers to assess their impact on drug release behavior. Mafenide, a widely used antibiotic, was chosen as the model drug for this investigation. The electrospinning process allowed for producing uniform and fine nanofibers with a high surface area, ensuring a large drug-loading capacity. The synthesized nanofibers were characterized using scanning electron microscopy (SEM) and Fourier transform infrared spectroscopy (FTIR) to evaluate their morphology, chemical interactions, and thermal properties. The drug release kinetics of the antibiotic-loaded nanofibers were studied under different physiological conditions to assess their sustained release behavior. Results: The final nanofiber formula was successfully prepared using the electrospinning technique. The Fourier Transform Infrared Spectroscopy (FTIR) analysis was achieved to confirm the possibility of chemical interaction and bond formation between mafenide and the polymers. Present. The SEM picture of the optimized nanofiber formula showed the homogeneity and excellent entanglement of the electrospun nanofibers at a resolution of 5 µm. PVA/chitosan/HPMC and mafenide pure drug have been successfully fabricated with sufficient strength to resist swelling after absorbing wound exudate. The polymer network becomes more compact when chitosan and Hydroxypropyl Methyl Cellulose (HPMC) are combined with polyvinyl alcohol (PVA), enabling regulated swelling during solvent ingress. The polymer composite's three-dimensional network influenced how quickly the medication was released from the matrix. Sample 2's polymer network traps the medication, gradually releasing after controlled swelling, resulting in a sustained release profile compared to blank sample according to the cumulative release (%) study of mafenide loaded nanofiber and mafenide drug blank sample. Conclusion: This research successfully demonstrated the fabrication of sustained-release antibiotic nanofibers using electrospinning and three biocompatible polymers. The systematic optimization approach using Design-Expert® software proved effective in tailoring the drug release behavior of nanofibers. The developed drug delivery system holds great promise for pharmaceutical applications, particularly in improving antibiotic therapies and patient care.

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Section: Fourier Transform Infrared Spectroscopy Analysismentioning

confidence: 99%

Preparation and Justification of Nanofibres-Loaded Mafenide Using Electrospinning Technique to Control Release

R. ATIYAH,

AL-EDRESI

2024

Int J App Pharm

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Synthesis, Characterization, Antimicrobial and Antimalarial Activities of Azines Based Schiff Bases and their Pd(II) Complexes

Meena

Baroliya

2023

Chemistry & Biodiversity

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Herein, we report synthesis, characterization, antimicrobial and antimalarial activities of azines Schiff base ligands (L 1 À L 4 ) and their palladium (II) complexes (C 1 À C 4 ) of [Pd(L)(OAc) 2 ] type. The azine ligands (L 1 À L 4 ) were prepared by condensation of carbonyl compounds with hydrazine hydrate and their complexes by the reaction of palladium acetate with L 1 À L 4 ligands in 1 : 1 molar ratio. The prepared ligands and their complexes were characterized by spectral characterization using 1 H & 13 C-NMR, FT-IR and mass spectral studies, which revealed that the ligands coordinates via azomethine nitrogen and heteroatom or aryl carbon with palladium. Moreover, Schiff bases and their palladium (II) complexes have been screened for their antibacterial (S. aureus, B. subtillis, and S. typhi, P. aeruginosa), antifungal (C. albicans, A. niger, and A. clavatus) and antimalarial (P. falciparum) activities. The Schiff base L 4 showed good results for antibacterial against S. aureus (MIC, 50 μg/mL) and antimalarial against P. falciparum (IC 50 , 0.83 μg/mL). The complex C 1 showed best antibacterial activity (MIC, 62.5 μg/mL) against S. typhi and the complex C 4 exhibited remarkable antimalarial activity (IC 50 , 0.42 μg/mL) among the tested compounds. Thus, azines based ligands and their Pd complexes can be good antimicrobial and antimalarial agents if explored further.

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Theoretical and experimental study of the diastereoisomers (2S) and (2R)-naringenin-6-C-β-D-glucopyranoside obtained from Clitoria guianensis

et al. 2023

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Antibacterial and antifungal activities in vitro of a novel silver(I) complex with sulfadoxine-salicylaldehyde Schiff base

Cited by 11 publications

References 58 publications

Preparation and Justification of Nanofibres-Loaded Mafenide Using Electrospinning Technique to Control Release

Preparation and Justification of Nanofibres-Loaded Mafenide Using Electrospinning Technique to Control Release

Synthesis, Characterization, Antimicrobial and Antimalarial Activities of Azines Based Schiff Bases and their Pd(II) Complexes

Theoretical and experimental study of the diastereoisomers (2S) and (2R)-naringenin-6-C-β-D-glucopyranoside obtained from Clitoria guianensis

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