Antibacterial and Antifungal Activity of Acyclic and Macrocyclic Uracil Derivatives with Quaternized Nitrogen Atoms in Spacers.

Семенов, В. Э.; Voloshina, Alexandra D.; Toroptzova, E. M.; Кулик, Н. В.; Зобов, В. В.; Giniyatullin, R. Kh.; Mikhailov, A. S.; Nikolaev, A. E.; Акамсин, В. Д.; Резник, В. С.

doi:10.1002/chin.200704148

Cited by 5 publications

(7 citation statements)

References 1 publication

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“…Table 2 revealed that the uracil-anisaldehyde Schiff base (UB) showed relatively higher antimicrobial activities than uracil-benzaldehyde Schiff base (UA). That could be attributed to the higher adsorption tendency of the oxygen atom in the methoxy groups (-O-CH 3 ) due to the lone pair of electrons of oxygen atom [26,27].…”

Section: Biological Activity Of the Synthesized Cationic Schiff Base mentioning

confidence: 99%

Screening for Potential Antimicrobial Activities of Some Cationic Uracil Biocides Against Wide‐Spreading Bacterial Strains

Negm

Aiad

Tawfik

2010

J Surfact & Detergents

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Eight novel uracil-based cationic surfactants containing Schiff base species were synthesized and characterized using elemental analysis, FTIR, 1 H-NMR and 13 C-NMR spectroscopy. The surface activities of the synthesized Schiff bases and their cationic derivatives were determined based on interfacial tension measurements and partition coefficient values in water/octanol system. The synthesized Schiff bases and their cationic derivatives were evaluated as novel biocides against different bacteria and fungi strains. The results showed that the biocidal activity of the synthesized Schiff bases was considerably increased by quaternization. The influence of the cationic surfactants as biocides was increased by increasing the hydrophobic chain length and the presence of the methoxy groups. The biocidal activity was also increased by increasing the partition coefficient in water/octanol system. The structure and surface activity/ biocidal activity of the different compounds were discussed.

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Section: Biological Activity Of the Synthesized Cationic Schiff Base mentioning

confidence: 99%

Screening for Potential Antimicrobial Activities of Some Cationic Uracil Biocides Against Wide‐Spreading Bacterial Strains

Negm

Aiad

Tawfik

2010

J Surfact & Detergents

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“…The target compounds 3 were synthesized by starting from substituted benzyl bromide 4 and diamines 5 a – c , the latter of which were obtained from dibromides 6 and ethylamine. This step was described elsewhere . Scheme shows the steps leading to bisamines 3 .…”

Section: Resultsmentioning

confidence: 99%

“…Initial compounds 5 a–c : The syntheses of initial compounds 1,3‐bis(4‐ethylaminobutyl)‐6‐methyluracil ( 5 a ), 1,3‐bis(5‐ethylaminopentyl)‐6‐methyluracil ( 5 b ), and 1,3‐bis(6‐ethylaminohexyl)‐6‐methyluracil ( 5 c ) were reported previously …”

Section: Methodsmentioning

confidence: 99%

6‐Methyluracil Derivatives as Bifunctional Acetylcholinesterase Inhibitors for the Treatment of Alzheimer's Disease

et al. 2015

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Novel 6-methyluracil derivatives with ω-(substituted benzylethylamino)alkyl chains at the nitrogen atoms of the pyrimidine ring were designed and synthesized. The numbers of methylene groups in the alkyl chains were varied along with the electron-withdrawing substituents on the benzyl rings. The compounds are mixed-type reversible inhibitors of cholinesterases, and some of them show remarkable selectivity for human acetylcholinesterase (hAChE), with inhibitory potency in the nanomolar range, more than 10,000-fold higher than that for human butyrylcholinesterase (hBuChE). Molecular modeling studies indicate that these compounds are bifunctional AChE inhibitors, spanning the enzyme active site gorge and binding to its peripheral anionic site (PAS). In vivo experiments show that the 6-methyluracil derivatives are able to penetrate the blood-brain barrier (BBB), inhibiting brain-tissue AChE. The most potent AChE inhibitor, 3 d (1,3-bis[5-(o-nitrobenzylethylamino)pentyl]-6-methyluracil), was found to improve working memory in scopolamine and transgenic APP/PS1 murine models of Alzheimer's disease, and to significantly decrease the number and area of β-amyloid peptide plaques in the brain.

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“…Minimal inhibitory concentrations (MICs) were estimated by conventional dilution methods for bacteria and fungi [57,58]. The antibacterial and antifungal assays were performed in Hottinger broth (HiMedia Laboratories Pvt.…”

Section: Fluorescencementioning

confidence: 99%

Self-assembling systems based on quaternized derivatives of 1,4-diazabicyclo[2.2.2]octane in nutrient broth as antimicrobial agents and carriers for hydrophobic drugs

Pashirova

Лукашенко

Захаров

et al. 2015

Colloids and Surfaces B: Biointerfaces

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Antibacterial and Antifungal Activity of Acyclic and Macrocyclic Uracil Derivatives with Quaternized Nitrogen Atoms in Spacers.

Cited by 5 publications

References 1 publication

Screening for Potential Antimicrobial Activities of Some Cationic Uracil Biocides Against Wide‐Spreading Bacterial Strains

Screening for Potential Antimicrobial Activities of Some Cationic Uracil Biocides Against Wide‐Spreading Bacterial Strains

6‐Methyluracil Derivatives as Bifunctional Acetylcholinesterase Inhibitors for the Treatment of Alzheimer's Disease

Self-assembling systems based on quaternized derivatives of 1,4-diazabicyclo[2.2.2]octane in nutrient broth as antimicrobial agents and carriers for hydrophobic drugs

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