ANTIBACTERIAL AND ANTIFUNGAL POTENTIAL OF EXTRACTS OF Anacardium occidentale

Andrade, Fernanda Pereira; Alves, T. W. B.; Romano, Tiziana; Medeiros, Francinalva Dantas de

doi:10.52571/ptq.v15.n30.2018.316_periodico30_pgs_313_321.pdf

Cited by 3 publications

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Food Composition Data: Edible Plants in Cerrado

et al. 2021

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181negative correlation between the in vitro potential of many molecules and their ADME/T (absorption, distribution, metabolism, excretion/toxicity) profile is generally noted (Gleeson et al. 2011). Synthetic compounds present a significantly lower number of chiral centers and are both smaller and present greater flexibility, which results in weaker, less specific activity (Feher and Schmidt 2003). In contrast, plantderived natural products present a diversity of bioactive compounds with differing chemical scaffolds (Atanasov et al. 2015). Plant-derived products possess properties, such as binding affinities for specific proteins, that are evolutionary optimized (Appendino et al. 2010;Hunter 2008). Such characteristics make plant-derived products more advantageous for conducting ADME/T tests (Atanasov et al. 2015). Another advantage in drug discovery using medicinal plants is the known good correlation between ethnopharmacological information (well documented) and the medical use of the plant. Around 80% of identified compounds present some ethnomedicinal use, whether identical or related to current usage of the active plant elements (Fabricant and Farnsworth 2001). Further, technological advances in systems biology, bioinformatics, plant specialized metabolism, and synthetic biology present opportunities through which the medicinal properties of plants are discovered, utilized, and expanded toward developing new herb-inspired medicines (Li and Weng 2017). Accordingly, plant-derived natural products still represent a valuable source for drug discovery, this, motivated by global public health challenges, such as COVID-19, HIV/AIDS, malaria, hypertension, diabetes, and cancer (Thomford et al. 2018). About a quarter of all Food and Drug Administration (FDA)-and/or European Medical Agency (EMA)-approved drugs are plant-derived (Patridge et al. 2016;Thomford et al. 2018).In this context, Brazil possesses various biomes with a great portion of the world's biodiversity and approximately 20% of the plants and microorganisms on the planet (Calixto 2000). Among these biomes, the Cerrado is a neotropical savanna with rich flora (Klink and Machado 2005). Over 13,127 highly endemic plant species have been recorded within this biome (Myers et al. 2000;Overbeck et al. 2015;Silva and Bates 2002;Silveira et al. 2016). Yet, in regard to environmental conservation, only 41% of the original Cerrado still remains as native vegetation (Soares-Filho et al. 2014). This reduction is due to anthropogenic activities, such as monoculture, pasture expansions, mineral extraction, and the growth of urban areas (Faleiro et al. 2013). Considering only agricultural activity between 2002 and 2009, an estimated loss of 92,712 km 2 of natural Cerrado area has occurred (Overbeck et al. 2015). Preservation policies in Brazil need improvement, yet only 7% of the Cerrado is under legal protection (Soares-Filho et al. 2014).Both the bio-prospecting potential of the Cerrado for medicinal species and knowledge concerning traditional medicines are disappear...

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Food Composition Data: Edible Plants in Cerrado

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Estudo etnofarmacológico de Anacardium occidentale: uma breve revisão

Araújo

Silva

Cândido

et al. 2020

RSD

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Introdução: Anacardium occidentale, conhecida popularmente como cajueiro, é uma planta nativa do Brasil e tem sido amplamente utilizada pela população devido suas propriedades medicinais. Objetivo: Realizar uma pesquisa bibliográfica para se evidenciar o perfil de utilização de A. occidentale como planta medicinal e correlacionar essas informações com pesquisas experimentais que evidenciem os potenciais biológicos desse vegetal. Metodologia: Trata-se de uma revisão de literatura do tipo narrativa. A busca de artigos ocorreu nas bases de dados Lilacs, Scielo e Periódicos Capes, por meio dos termos: 1) Anacardium occidentale; 2) Cajueiro e 3) Atividades Biológicas, utilizando-se os operadores booleanos “AND” e “OR”. Resultados: De 40 estudos analisados, 17 foram utilizados para compor os resultados. Evidenciou-se, o uso do cajueiro por diferentes populações para o tratamento de inflamações, acidente cerebrovascular, ferimentos, diarreia, infecções, cefaleia, odontalgia, ressaca, como adstringente, anticoagulante, antigripal, antitérmico e cicatrizante. Dentre essas indicações, destacam-se anti-inflamatória, cicatrizante, antidiarreica, antigripal e antimicrobiana, devido a existência de estudos experimentais comprovando esses diferentes potenciais biológicos. Extratos de frutos, folhas e caule, demostram potencial anti-inflamatório. O extrato de cascas apresenta potencial cicatrizante, devido a presença de compostos fenólicos, que parecem favorecer a reconstrução tecidual, por seus efeitos cicatrizante, antibacteriano e por exercer influência sobre mediadores envolvidos na inflamação. Com relação ao potencial antidiarreico, estudos com extrato de cascas de caule e com goma de A. occidentale demonstraram redução do trânsito gastrintestinal, aumento da reabsorção de água e eletrólitos e retardo do início da diarreia. Ademais, foram obtidas quantidades elevadas de flavonoides e moderada de alcaloides e taninos. Quanto à atividade antigripal, observou-se uma promissora atividade anti-influenza, mediante a capacidade de inibir a enzima neuraminidase e inibir a replicação viral em camundongos. A atividade antimicrobiana, foi verificada em bactérias Gram-positivas e negativas e fungos, sendo associada à presença de alcaloides e taninos. Conclusão: Assim, compreende-se que o cajueiro apresenta uma gama de indicações terapêuticas no uso popular, entre as quais se destaca o seu potencial nos processos anti-inflamatórios, cicatriciais, antidiarreicos, antigripais e antimicrobianos, contudo cabe ressaltar que são necessárias mais pesquisas que esclareçam melhor os possíveis mecanismos envolvidos.

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Polyphenols of four medicinal plants extracts and relation with antifungal activities through in vitro and in silico studies

Lopes,

Frota,

Neves

et al. 2024

CeN

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Several medicinal plant´s extracts contain phenolic compounds with antifungal properties useful in pharmaceutical formulations. This study selected species from Cocó River State Park in Fortaleza, Ceará, Brazil, and compare their efficiency as antifungal products. To achieve this goal phenolic profile and anticandidal actions of extracts were evaluated, main constituents were characterized and correlated with antifungal properties through in vitro and in silico studies. Anacardium occidentale, Myracrodruon urundeuva, Laguncularia racemosa, and Terminalia catappa were chosen. The plant parts were collected in accordance with folk medicine recommendation. The main compounds present in the extracts were gallic acid, epicatechin, ellagic acid, isoquercitrin, quercetin and rutin, detected by high performance liquid chromatography analysis. The anticandidal activity of extracts varied from high to moderate, and A. occidentale present the best activity followed by L. racemosa. The in silico studies revealed that affinity energy (∆G) for ellagic acid (-9.4), isoquercitrin (-9.3) and rutin (-9.0) kcal moL-1 were better in relation to secreted aspartic proteinase 5 (Sap5) from Candida albicans, nevertheless ellagic acid and isoquercitrin act in different places in relation to the active site of Sap5 and could act in synergism with fluconazole.

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ANTIBACTERIAL AND ANTIFUNGAL POTENTIAL OF EXTRACTS OF Anacardium occidentale

Cited by 3 publications

References 4 publications

Food Composition Data: Edible Plants in Cerrado

Food Composition Data: Edible Plants in Cerrado

Estudo etnofarmacológico de Anacardium occidentale: uma breve revisão

Polyphenols of four medicinal plants extracts and relation with antifungal activities through in vitro and in silico studies

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