Antibacterial and Antioxidant Potential of Stem Bark Extract of Bombax Ceiba Collected Locally From South Punjab Area of Pakistan

Abstract

Background: Ethnic medication systems have been used extensively by humans since their origin. Now a day, in the developing countries these systems are being used due to their effectiveness and affordability. Especially inhabitants of rural areas still rely on these systems as first line of treatment against diseased conditions. Till now, majority of medicines is derived from the natural origin particularly plants owing to their little side effects and cost effectiveness. Materials and Methods:In the present work, we evaluated antibacterial and antioxidant activity of methanolic extract of Bombax ceiba stem bark. Total phenolic and flavonoid contents were also assessed in the extract. The antioxidant capacity was determined by DPPH, Nitric Oxide scavenging and reducing power activity. For antibacterial activity, Gram-negative (Escherichia coli, Pseudomonas aeruginosa and Salmonella typhi) and Gram-positive bacteria (Bacillus subtilis, Staphylococcus aureus) were used. Results: Phenolic content was 133.21±1.56 µg GAE/mg of extract while Flavonoid content was 997.93±2.14 µg QE/mg. Plant extract demonstrated strong antiradical activity with EC 50 18.78 ± 0.69 and 23.62 ± 1.99µg/ml for Nitric Oxide and DPPH assay respectively while EC 50 in case of reducing power activity was 139.4 ± 0.98µg/ml. Plant extract displayed inhibitory effect against microbial growth with S. typhi as the most resistant strain and Staphylococcus aureus the most sensitive one. Conclusion: This study revealed that Bombax ceiba of local origin has broad spectrum antibacterial activity and it can also provide defense against oxidative stress.

Antidiabetic and Hepatoprotective Activities of Bombax ceiba Young Roots in Alloxan-Induced Diabetic Mice

“…Different parts of this plant are reported to have therapeutic potentials against different diseases such as diabetes, hepatic toxicity, infections, asthenia, polyurea and glycosuria [9][10][11][12]. Although different parts of B. ceiba are known to have different biological activities including antioxidant, antimicrobial, anti-inflammatory and analgesic, ,hypotensive and hypoglycemic activity, very little work has been done by taking an ethanolic extract of young roots of B. ceiba (BCYR) on diabetes and hepatic toxicity [9,10,[13][14][15]. Therefore, the present study was undertaken to investigate the effects of the BCYR on diabetes and hepatic toxicity in Alloxan-Induced Diabetic Mice (AIDM).…”

Antidiabetic and Hepatoprotective Activities of Bombax Ceiba Extract in Obese Rats With Metabolic Syndrome

“…Therapeutic potentials against various diseases such as diabetes, infections, asthenia, polyurea, glycosuria and hepatic toxicity are reported in different parts of this plant. Although various portions of B. ceiba has different therapeutic activities, including hypoglycemic, antiinflammatory, analgesic, antioxidant, antimicrobial and hypotensive activity, but only little research has been reported to evaluate the effect of ethanolic extract of B. ceiba young roots on diabetes and liver toxicity (Rehman et al, 2017).…”

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“…1A is a compound of the saponin group which has been isolated from Jatropha tanjorensis 21 , Annona reticulata L. 22 , Abroma augusta 23, and play a role in prostate cancer 24 and protects the human hepatic LO2 cells 25 . In this study, we report the isolation of a taraxerol (1) and β-sitosterol glucoside (2) from EtOH extract of leaves.…”