Antibacterial and Biological Properties of a Micro-structured BMP-2/Chitosan/Hydroxyapatite Hybrid Coating on Ti Surface

Wang, Xiaolin; Li, Baoe; Liu, Shimin; Zhang, Ce; Hao, Jingzu

doi:10.2485/jhtb.28.303

Cited by 3 publications

(2 citation statements)

References 28 publications

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“…Vascular Endothelial Growth Factor (VEGF), as a key growth factor, directly stimulates new blood vessel formation. These biological factors are typically incorporated onto material surfaces through gentle methods, such as the dip-coating method [115,116], immersion [110], and chemical deposition [109], to ensure the preservation of their activity.…”

Section: Osteointegrationmentioning

confidence: 99%

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Micro-Arc Oxidation in Titanium and Its Alloys: Development and Potential of Implants

Ming,

Wu,

Zhang

et al. 2023

Coatings

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Titanium (Ti) and its alloys are widely recognized as preferred materials for bone implants due to their superior mechanical properties. However, their natural surface bio-inertness can hinder effective tissue integration. To address this challenge, micro-arc oxidation (MAO) has emerged as an innovative electrochemical surface modification technique. Its benefits range from operational simplicity and cost-effectiveness to environmental compatibility and scalability. Furthermore, the distinctive MAO process yields a porous topography that bestows versatile functionalities for biological applications, encompassing osteogenesis, antibacterial, and anti-inflammatory properties. In this review, we undertake an examination of the underlying mechanism governing the MAO process, scrutinize the multifaceted influence of various factors on coating performance, conduct an extensive analysis of the development of diverse biological functionalities conferred by MAO coatings, and discuss the practical application of MAO in implants. Finally, we provide insights into the limitations and potential pathways for further development of this technology in the field of bone implantation.

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Section: Osteointegrationmentioning

confidence: 99%

“…CS can be fixed on the MAO coating by dip coating [153]. For example, BMP-2-encapsulated CS gives the coating good osteogenic and antibacterial properties [115].…”

Section: Antibacterialmentioning

confidence: 99%

Micro-Arc Oxidation in Titanium and Its Alloys: Development and Potential of Implants

Ming,

Wu,

Zhang

et al. 2023

Coatings

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The race for the optimal antimicrobial surface: perspectives and challenges related to plasma electrolytic oxidation coating for titanium-based implants

Costa

Nagay

Dini

et al. 2023

Advances in Colloid and Interface Science

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Organic-Inorganic Biocompatible Coatings for Temporary and Permanent Metal Implants

Parfenova,

Galimshina,

Parfenov

2024

IJMS

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The general trend of increasing life expectancy will consistently drive the demand for orthopedic prostheses. In addition to the elderly, the younger population is also in urgent need of orthopedic devices, as bone fractures are a relatively common injury type; it is important to treat the patient quickly, painlessly, and eliminate further health complications. In the field of traumatology and orthopedics, metals and their alloys are currently the most commonly used materials. In this context, numerous scientists are engaged in the search for new implant materials and coatings. Among the various coating techniques, plasma electrolytic oxidation (PEO) (or micro-arc oxidation—MAO) occupy a distinct position. This method offers a cost-effective and environmentally friendly approach to modification of metal surfaces. PEO can effectively form porous, corrosion-resistant, and bioactive coatings on light alloys. The porous oxide surface structure welcomes organic molecules that can significantly enhance the corrosion resistance of the implant and improve the biological response of the body. The review considers the most crucial aspects of new combined PEO-organic coatings on metal implants, in terms of their potential for implantation, corrosion resistance, and biological activity in vitro and in vivo.

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Antibacterial and Biological Properties of a Micro-structured BMP-2/Chitosan/Hydroxyapatite Hybrid Coating on Ti Surface

Cited by 3 publications

References 28 publications

Micro-Arc Oxidation in Titanium and Its Alloys: Development and Potential of Implants

Micro-Arc Oxidation in Titanium and Its Alloys: Development and Potential of Implants

The race for the optimal antimicrobial surface: perspectives and challenges related to plasma electrolytic oxidation coating for titanium-based implants

Organic-Inorganic Biocompatible Coatings for Temporary and Permanent Metal Implants

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