Antibacterial and cytocompatible nanotextured Ti surface incorporating silver via single step hydrothermal processing

Mohandas, Anu; Krishnan, Amit G; Biswas, Raja; Menon, Deepthy; Nair, Manitha B.

doi:10.1016/j.msec.2017.02.037

Cited by 26 publications

(20 citation statements)

References 40 publications

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“…With regards to testing silver-coated implants, valuable data can be gained from laboratory-based testing, for example using saline or simulated body fluid as carrier solutions. However due to the chemical complexities of using this transition metal, the analysis of silver elution from implants placed in clinically relevant in vivo localities is essential 32 , 33 . Previous reporting of release profiles from silver technologies have shown a rapid increase in silver at day 2 following sub-cutaneous implantation, declining thereafter from day 6 15 .…”

Section: Discussionmentioning

confidence: 99%

Identification of mesenchymal stromal cell survival responses to antimicrobial silver ion concentrations released from orthopaedic implants

Souter

Vaughan

Butcher

et al. 2020

Sci Rep

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Antimicrobial silver (Ag+) coatings on orthopaedic implants may reduce infection rates, but should not be to the detriment of regenerative cell populations, primarily mesenchymal stem/stromal cells (MSCs). We determined intramedullary silver release profiles in vivo, which were used to test relevant Ag+ concentrations on MSC function in vitro. We measured a rapid elution of Ag+ from intramedullary pins in a rat femoral implantation model, delivering a maximum potential concentration of 7.8 µM, which was below toxic levels determined for MSCs in vitro (EC50, 33 µM). Additionally, we present in vitro data of the reduced colonisation of implants by Staphylococcus aureus. MSCs exposed to Ag+ prior to/during osteogenic differentiation were not statistically affected. Notably, at clonal density, the colony-forming capacity of MSCs was significantly reduced in the presence of 10 µM Ag+, suggesting that a subpopulation of clonal MSCs was sensitive to Ag+ exposure. At a molecular level, surviving colony-forming MSCs treated with Ag+ demonstrated a significant upregulation of components of the peroxiredoxin/thioredoxin pathway and processes involved in glutathione metabolism compared to untreated controls. Inhibition of glutathione synthesis using l-buthionine sulfoxamine eliminated MSC clonogenicity in the presence of Ag+, which was rescued by exogenous glutathione.

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Section: Discussionmentioning

confidence: 99%

Identification of mesenchymal stromal cell survival responses to antimicrobial silver ion concentrations released from orthopaedic implants

Souter

Vaughan

Butcher

et al. 2020

Sci Rep

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“…AgNPs can exist in the form of metallic silver with atoms strongly connected with each other [ 34 ]. The typical AgNPs are usually of a few to a dozen nm in diameter [ 35 ] and can take different shapes (spherical, irregular or planar) [ 9 , 20 , 24 , 25 , 26 , 27 , 28 , 36 , 37 , 38 ] that depend on the methods of production. One of the most popular “bottom up” eco-friendly method is biological synthesis, using living cells of bacteria, fungi and plants to obtain silver nanoparticles [ 9 , 15 , 16 , 17 , 19 , 24 , 27 , 37 , 38 ].…”

Section: Properties Of Silver Materials Vs Antibacterial Activitymentioning

confidence: 99%

“…In 2017 Sheng et al [ 9 ] reviewed that over 1000 articles concerned the effects of nanoparticles on bacteria and over 90% of them were published after 2008. At present, more and more publications concerning the synthesis and antibacterial activity of silver nanoforms are being published [ 10 , 11 , 12 , 13 , 14 , 15 , 16 , 17 , 18 , 19 , 20 , 21 , 22 , 23 , 24 , 25 , 26 , 27 , 28 , 29 , 30 , 31 , 32 ].…”

Section: Introductionmentioning

confidence: 99%

Similarities and Differences between Silver Ions and Silver in Nanoforms as Antibacterial Agents

Kędziora

Speruda

Krzyżewska

et al. 2018

IJMS

368

290

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Silver is considered as antibacterial agent with well-known mode of action and bacterial resistance against it is well described. The development of nanotechnology provided different methods for the modification of the chemical and physical structure of silver, which may increase its antibacterial potential. The physico-chemical properties of silver nanoparticles and their interaction with living cells differs substantially from those of silver ions. Moreover, the variety of the forms and characteristics of various silver nanoparticles are also responsible for differences in their antibacterial mode of action and probably bacterial mechanism of resistance. The paper discusses in details the aforementioned aspects of silver activity.

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“…To solve this problem, Jin et al used metal antibacterial agents such as silver and zinc to make the metal surface resistant to bacteria [110]. Recently, Mohandas et al used a one-step hydrothermal method to prepare nano-titanium dioxide embedded in silver nanoparticles under alkaline pH conditions of silver salts [111]. Nano-silver-modified Ti surface not only had strong antibacterial properties, but also promoted the activity, proliferation, and osteogenic differentiation of MSCs.…”

Section: Application Of Nanoparticles In Biomaterialsmentioning

confidence: 99%

Micro-/Nano-Scales Direct Cell Behavior on Biomaterial Surfaces

Wang

Zhou

et al. 2018

Molecules

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Cells are the smallest living units of a human body’s structure and function, and their behaviors should not be ignored in human physiological and pathological metabolic activities. Each cell has a different scale, and presents distinct responses to specific scales: Vascular endothelial cells may obtain a normal function when regulated by the 25 µm strips, but de-function if the scale is removed; stem cells can rapidly proliferate on the 30 nm scales nanotubes surface, but stop proliferating when the scale is changed to 100 nm. Therefore, micro and nano scales play a crucial role in directing cell behaviors on biomaterials surface. In recent years, a series of biomaterials surface with micro and/or nano scales, such as micro-patterns, nanotubes and nanoparticles, have been developed to control the target cell behavior, and further enhance the surface biocompatibility. This contribution will introduce the related research, and review the advances in the micro/nano scales for biomaterials surface functionalization.

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Antibacterial and cytocompatible nanotextured Ti surface incorporating silver via single step hydrothermal processing

Cited by 26 publications

References 40 publications

Identification of mesenchymal stromal cell survival responses to antimicrobial silver ion concentrations released from orthopaedic implants

Identification of mesenchymal stromal cell survival responses to antimicrobial silver ion concentrations released from orthopaedic implants

Similarities and Differences between Silver Ions and Silver in Nanoforms as Antibacterial Agents

Micro-/Nano-Scales Direct Cell Behavior on Biomaterial Surfaces

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