Antibacterial and cytotoxic potency of thermophilic Streptomyces werraensis MI-S.24-3 isolated from an Egyptian extreme environment

Mohamed, Hassan; Hassane, Abdallah M. A.; Rawway, Mohammed; Elsayed, Mohamed A.; Gomaa, Abd El-Rahman F.; Abdul‐Raouf, Usama M.; Shah, Aabid Manzoor; Abdelmotaal, Heba; Song, Yuanda

doi:10.1007/s00203-021-02487-0

Cited by 20 publications

(9 citation statements)

References 45 publications

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“…According to the results acquired from the in vitro antimicrobial assays, the MIC for the synthesized Ag NP against a wide range of Gram-negative bacteria ranged from 9.03 to 11.8 μg•mL -1 , while MBC ranged from 56.26 to 76.71 μg•mL -1 . MBC was defned as the lowest active concentration, killing approximately 99.9% of the bacterial inocula after 24 h incubation at 37 °C [78]. Data (Table 2) showed that both MBC and MIC showed nonsignifcant diferent values (p < 0.05) among microorganisms.…”

Section: Evaluation Of the Antibacterial Activity Of Agnps (In Vitro)mentioning

confidence: 96%

Phytotoxicity and Antimicrobial Activity of Green Synthesized Silver Nanoparticles Using Nigella sativa Seeds on Wheat Seedlings

Elshazly

Mohamed

Aboelmagd

et al. 2022

Journal of Chemistry

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Recently, the green synthesis of nanomaterials has grown in popularity and has become one of the most used approaches. Plant extracts are safe for the environment and could be cost-effective for nanoparticle preparation. Silver nanoparticles (AgNPs) have been synthesized using aqueous extracts of Nigella sativa (N. sativa) seeds. The formation of AgNPs was confirmed by using an X-ray diffractometer, a UV-visible spectrometer, and a transmission electron microscope. The phytotoxicity and genotoxicity of different AgNP concentrations (12.5, 25, 50, 75, and 100 μg·L−1) were evaluated by wheat (Triticum aestivum L.) seed germination. The results showed that AgNPs did not significantly affect germination, while root and coleoptile lengths decreased considerably. On the contrary, the biomass of seedlings markedly increased in response to AgNP treatments. Moreover, genotoxicity was detected, especially at high concentrations of AgNPs. DNA, RNA, and total soluble proteins of wheat seedlings significantly decreased. In addition, antimicrobial activities of biosynthesized AgNPs were detected.

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Section: Evaluation Of the Antibacterial Activity Of Agnps (In Vitro)mentioning

confidence: 96%

Phytotoxicity and Antimicrobial Activity of Green Synthesized Silver Nanoparticles Using Nigella sativa Seeds on Wheat Seedlings

Elshazly

Mohamed

Aboelmagd

et al. 2022

Journal of Chemistry

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“…Streptomyces secrete bisanthraquinone, carbomycin, glaciapyrroles, and tirandamycins that also display antibacterial activity ( Harir et al, 2018 ). Recently, thermophilic Streptomyces werraensis MI S.24 3, isolated from a very harsh environment in Egypt, has both antibacterial and cytotoxic properties ( Mohamed et al, 2021 ).…”

Section: Natural Products From Streptomycesmentioning

confidence: 99%

Streptomyces: The biofactory of secondary metabolites

et al. 2022

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Natural products derived from microorganisms serve as a vital resource of valuable pharmaceuticals and therapeutic agents. Streptomyces is the most ubiquitous bacterial genus in the environments with prolific capability to produce diverse and valuable natural products with significant biological activities in medicine, environments, food industries, and agronomy sectors. However, many natural products remain unexplored among Streptomyces. It is exigent to develop novel antibiotics, agrochemicals, anticancer medicines, etc., due to the fast growth in resistance to antibiotics, cancer chemotherapeutics, and pesticides. This review article focused the natural products secreted by Streptomyces and their function and importance in curing diseases and agriculture. Moreover, it discussed genomic-driven drug discovery strategies and also gave a future perspective for drug development from the Streptomyces.

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“…One approach is to discover novel sources for antimicrobial compounds that can be developed into future treatments. In recent years, more and more studies have reported volatiles with antimicrobial activity which indicates that volatiles might play an important role in countering the antimicrobial resistance crisis [ 18 , 19 , 20 , 21 ]. For example, the new volatile antibiotics albaflavenone and pentalenolactone produced by Streptomyces coelicolor and Streptomyces avermitilis , respectively were discovered [ 22 ].…”

Section: Antimicrobial Resistance: a Global Crisismentioning

confidence: 99%

Air Ambulance: Antimicrobial Power of Bacterial Volatiles

2022

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We are currently facing an antimicrobial resistance crisis, which means that a lot of bacterial pathogens have developed resistance to common antibiotics. Hence, novel and innovative solutions are urgently needed to combat resistant human pathogens. A new source of antimicrobial compounds could be bacterial volatiles. Volatiles are ubiquitous produced, chemically divers and playing essential roles in intra- and interspecies interactions like communication and antimicrobial defense. In the last years, an increasing number of studies showed bioactivities of bacterial volatiles, including antibacterial, antifungal and anti-oomycete activities, indicating bacterial volatiles as an exciting source for novel antimicrobial compounds. In this review we introduce the chemical diversity of bacterial volatiles, their antimicrobial activities and methods for testing this activity. Concluding, we discuss the possibility of using antimicrobial volatiles to antagonize the antimicrobial resistance crisis.

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Antibacterial and cytotoxic potency of thermophilic Streptomyces werraensis MI-S.24-3 isolated from an Egyptian extreme environment

Cited by 20 publications

References 45 publications

Phytotoxicity and Antimicrobial Activity of Green Synthesized Silver Nanoparticles Using Nigella sativa Seeds on Wheat Seedlings

Phytotoxicity and Antimicrobial Activity of Green Synthesized Silver Nanoparticles Using Nigella sativa Seeds on Wheat Seedlings

Streptomyces: The biofactory of secondary metabolites

Air Ambulance: Antimicrobial Power of Bacterial Volatiles

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