Antibacterial and Cytotoxic Potential of Biosynthesized Silver Nanoparticles by Some Plant Extracts

Mohammed, Afrah E.; Alqahtani, Alaa M.; Al-Mutairi, Amal; Al-Shamri, Bashayir; Aabed, Kawther

doi:10.3390/nano8060382

Cited by 98 publications

(70 citation statements)

References 53 publications

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“…Interactions between metabolites in the extract and metal ions cause the bioreduction of metal salts and synthesis of nanoparticles. The functional groups in the plant extract act as reducing, capping, and stabilizing agents [58,68]. Negatively charged (COO − ) and polar (OH and CO) groups presented in the plant extract attach on the Ag surface with high tendency and contribute in both reduction and stabilization of AgNPs [69].…”

Section: Fourier Transform Infrared Spectroscopymentioning

confidence: 99%

Phyto-mediated silver nanoparticles via Mellisa officinalis aqueous and methanolic extracts: synthesis, characterization and biological properties

Nayeri

Mafakheri

Mirhosseini

2020

Preprint

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The aim of the study was to examine the influence of extraction method on the size, shape and morphology of synthesized silver nanoparticles (AgNPs). Silver nanoparticles were prepared by the aqueous and methanolic extracts of lemon balm. The properties of obtained nanoparticles were characterized by UV-Vis, SEM, XRD and FTIR techniques. The UV-Vis spectroscopy confirmed the formation of AgNPs by observing a distinct surface Plasmon resonance band around 450 nm. SEM images showed different shape, size and morphology of AgNPs using two different extracts types. AgNPs derived from the aqueous extract were rod-shaped with a diameter of 19 to 40 nm whereas spherical particles were synthesized by the methanolic extract found smaller with size distribution ranging from 13 to 35 nm. The XRD pattern indicated that AgNPs formed by the reduction of Ag + ions using methanolic extract of M. officinalis were crystal-like in nature. The functional groups of M. officinalis methanolic extract involved in synthesis and stabilization of AgNPs were investigated by FTIR. In addition, AgNPs-containing methanolic extract showed higher antioxidant activity. These particles exhibited remarkable antimicrobial activity against gram positive and negative bacteria and a fungus. The nanoparticles produced by the methanolic extract of the lemon balm showed antioxidant and antimicrobial activity. The production of silver nanoparticles using plant extract is rapid, low cost and eco-friendly. Therefore, green chemistry is a good alternative to industrial production of nanoparticles. Silver nanoparticles can be used as an antiseptic to sterilize the surrounding area and the hospital wastes.

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Section: Fourier Transform Infrared Spectroscopymentioning

confidence: 99%

Phyto-mediated silver nanoparticles via Mellisa officinalis aqueous and methanolic extracts: synthesis, characterization and biological properties

Nayeri

Mafakheri

Mirhosseini

2020

Preprint

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“…Over 50% of all modern clinical drugs are of natural product origin and natural products play an important role in drug development programs in the pharmaceutical industries. [2,3] Acacia nilotica (Babul tree) is the member of the family Mimosaceae; Acacia nilotica is multipurpose nitrogen fixing tree legume. It is widely spread in subtropical and tropical Africa from Egypt to Mauritania southwards to South Africa, and in Asia eastwards to Pakistan and India.…”

Section: Introductionmentioning

confidence: 99%

Phytochemical screening and antimicrobial activities studies ofAcacia niloticafruit cover

Abdalla

Mustafa

Makhawi

2020

Preprint

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This study was carried out in Khartoum state, during November, 2019. Acacia nilotica was chosen for this study because of its using traditionally in treatment of many diseases. The Phytochemical constitutions of A. nilotica were investigated with aim to identify the antimicrobial effects of this plant. The dried fruit cover of Acacia nilotica was extracted successively with petroleum-ether, chloroform, methanol and distilled water. The phytochemical screening carried out on different extracts of Acacia nilotica fruit cover showed high amount of Glycosides, Flavonoids and Terpenoids (in all extracts) and moderate amount of Tannin in methanol and distilled water extracts, Alkaloids (acid and base) in methanol extract and Saponin in methanol and petroleum-ether extracts . The antimicrobial activity of extracts were evaluated against four standard bacteria species (gram positive bacteria; Staphylococcus aureus, Bacillus subtilis) and (gram negative bacteria; Pseudomonas aeruginosa, Escherichia coli). The plates were inoculated for sensitivity testing, minimum inhibitory concentration (MIC) was measured. The results of antimicrobial investigation show that the distilled water and methanolic extracts inhibited the growth of all microorganisms (Specified by the zone of inhibition). The results provide promising baseline information for potential use of these crude extracts in drug development programs in the pharmaceutical industries.

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“…The pH 8 (20%) 6.0x10 9 4.8x10 9 4.8x10 9 4.8x10 9 4.8x10 9 more than 100 nm, and with a negative zeta potential (Mohammed et al, 2018;Singh et al, 2015). Kokila et al (2016) showed that silver nanoparticles synthesized from Carica papaya bark extract had great stability due to their coating.…”

Section: Discussionmentioning

confidence: 99%

Antimicrobial Activity of Biogenic Hop-Based Silver Nanoparticles for Application in Sugar and Alcohol Industries

Borsari

Germano-Costa

Bilesky-José

et al. 2019

Journal of Siberian Federal University. Biology

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One of the largest problems in the sugar and alcohol industry is the presence of unwanted bacteria, which leads to a decrease in alcohol production. This work presents a possible way to control these undesirable bacteria using silver biogenic nanoparticles synthesized from hops. The research was aimed at synthesizing nanoparticles and evaluating their physical and chemical characteristics, antimicrobial activity and cytotoxic potential. Silver nanoparticles were synthesized using Humulus lupulus L. extract and silver nitrate solution (10-3 M). To evaluate the size and polydispersity, the dynamic light scattering (DLS) technique was used. The zeta potential and concentration of nanoparticles were assessed by microelectrophoresis and the nanoparticle tracing (NTA) technique, respectively. The analysis of the antimicrobial activity was performed by the disc diffusion test and by determining the minimum inhibitory concentration (MIC) against gram-positive bacteria. Cytotoxicity was assessed by the mitochondrial activity assay (MTT). The biogenic nanoparticles were shown to have bactericidal activity and the appropriate characteristics. Regarding the activity, the results showed that the nanoparticles obtained at pH 7 (with 5% hop flower extract) inhibited all tested bacteria at concentrations of 2.1 to 4.3 × 109 NP/mL, and the nanoparticles obtained at pH 8 (with 20% hop flower extract) inhibited the tested bacteria at concentrations of 4.8 to 6.0 × 109 NPs/mL, which means that the former presented higher potential bactericidal activity. Regarding cytotoxicity, nanoparticles of both types showed a low cell death index, and the cell viability was above 70%. Hops served as an effective stabilizing and reducing agent. The nanoparticles were effective in bacterial control and did not show cytotoxicity

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Antibacterial and Cytotoxic Potential of Biosynthesized Silver Nanoparticles by Some Plant Extracts

Cited by 98 publications

References 53 publications

Phyto-mediated silver nanoparticles via Mellisa officinalis aqueous and methanolic extracts: synthesis, characterization and biological properties

Phyto-mediated silver nanoparticles via Mellisa officinalis aqueous and methanolic extracts: synthesis, characterization and biological properties

Phytochemical screening and antimicrobial activities studies ofAcacia niloticafruit cover

Antimicrobial Activity of Biogenic Hop-Based Silver Nanoparticles for Application in Sugar and Alcohol Industries

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