Antibacterial and Enzyme Inhibition Screening of Some New Acetamide and Azomethine Derivatives

Abstract

The synthesis of poly-functional moieties as one unit has been under consideration by the synthetic chemists to search out new potent molecules. 2-Chlorobenzoic acid (1) was converted to 5-(2-chlorophenyl)-1,3,4-Oxadiazol-2-thiol (4) through a series of steps. This nucleophile was attached with different electrophiles, prepared by the reaction of aryl/alkyl amines with 2-bromoacetylbromide, in NaH/DMF to synthesize N-substituted-2-( (5-(2-chlorophenyl)-1,3,4-Oxadiazol-2-yl)sulfanyl)acetamide, 7a-f. The molecule 4 was stepped to ethyl ester and carbohydrazide. The carbohydrazide was made to react with aryl carboxaldehydes in methanol to synthesize N 3,acetohydrazide, 11a-i. The structures of all the molecules were corroborated through IR, 1 H-NMR and EI-MS spectral data. Both the series were screened for antibacterial and enzyme inhibition activity.

Synthesis and cytotoxic activity evaluation of some new 1, 3, 4-oxadiazole, 1, 3, 4-thiadiazole and 1, 2, 4- triazole derivatives attached to phthalimide

“…TLC was processed to monitor the reaction completion. The product was acquired by the addition of excess cold water and separated by filtration, washed by n-hexane, and dried ( 28 29 ) ( Scheme 1 ).…”