Antibacterial and mechanical properties of bone cement impregnated with chitosan nanoparticles

Shi, Zhijun; Neoh, K. G.; Kang, En‐Tang; Wang, Wilson

doi:10.1016/j.biomaterials.2005.11.036

Cited by 355 publications

(279 citation statements)

References 36 publications

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“…Because systemic antibiotics often do not provide effective treatment for implant infections due to the phenomenon of drug resistance, it is important that the coating of the implant exhibit local antibacterial activity. In order to reduce the incidence of implant-associated infections, several biomaterial surface treatments have been proposed [18][19][20][21][22][23][24][25][26][27][28][29][30]. In particular, silver has raised the interest of many investigators because of its good antimicrobial action and low toxicity [30,[40][41][42][43].…”

Section: Discussionmentioning

confidence: 99%

“…Several biomaterial surface treatments have been proposed as a means of reducing the incidence of implant-associated infections. There has been investigation into the covalent attachment of polycationic groups [18,19]; ion implantation, such as F+ [20]; impregnating or loading chitosan nanoparticles with antimicrobial agents [21,22]; coating implant surfaces with polymers drug-loaded [23,24]; and coating implant surfaces with either quaternary ammonium compounds, human serum albumin, or silver ions [25][26][27][28][29][30]. However, there are several shortcomings of these proposed techniques including limited chemical stability, local inflammatory reactions due to material composition, and a lack of controlled release kinetics from the coatings.…”

Section: Introductionmentioning

confidence: 99%

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Antibacterial iodine-supported titanium implants

et al. 2011

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Deep infection remains a serious complication in orthopedic implant surgery. In order to reduce the incidence of implant-associated infections, several biomaterial surface treatments have been proposed. This study focused on evaluating the antibacterial activity of iodine-supported titanium (Ti-I 2 ) and impact on post-implant infection, as well as determining the potential suitability of Ti-I 2 as a biomaterial.External fixation pins were used in this experiment as trial implants because it was easy to make the septic models.The antibacterial activity of the metal was measured using a modification of the Japanese Industrial Standards method. Activity was evaluated by exposing the implants to Staphylococcus aureus or Escherichia coli and comparing reaction of pathogens to the Ti-I 2 versus the stainless steel and titanium controls. The Ti-I 2 clearly inhibited bacterial colonization more than the control metals. In addition, cytocompatibility was assessed by counting the number of colonies that formed on the metals. The three metals showed the same amount of fibroblast colony formation.Japanese white rabbits were used as an in vivo model. Three pins were inserted into both femora of six rabbits for histological analysis. Pin sites were inspected and graded for infection and inflammation. Fewer signs of infection and inflammatory changes were observed in conjunction with the Ti-I 2 pins. Furthermore, osteoconductivity of the implant was evaluated with osteoid formation surface of the pin. Consecutive bone formation was observed around the Ti-I 2 and titanium pins, while little osteoid formation was found around the stainless steel pins. These findings suggest that Ti-I 2 has antimicrobial activity and cytocompatibility.Therefore, Ti-I 2 substantially reduces the incidence of implant infection and shows particular promise as a biomaterial.

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Antibacterial iodine-supported titanium implants

et al. 2011

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“…Basic research has been conducted regarding various metal surface treatments to reduce the rate of implant-associated infection [3][4][5][6][7][8]. Masse et al [16] used silver-coated pins for external fixation and reported an infection rate of 30%.…”

Section: Discussionmentioning

confidence: 99%

“…Such efforts included the development of antibacterial pins made of titanium-copper alloys [3] and metal surface treatment involving silver, antibacterial agents, hyaluronic acid, and albumin [4][5][6][7][8]. We have been creating an oxide film on titanium surfaces by anodization and have been developing techniques to impregnate this multiple porous film with the antiseptic properties of iodine (Fig.…”

Section: Introductionmentioning

confidence: 99%

Prevention of pin tract infection with iodine-supported titanium pins

Shirai

Watanabe

Matsubara

et al. 2014

Journal of Orthopaedic Science

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“…It contains more than 5000 glucosamine units and is derived from alkaline deacetylation of chitin that is obtained from the shells of crustaceans (Fig 2.) and is available in a variety of physical forms: film, fiber, bead, powder, or as nanoparticles (137). Chitosan is insoluble in most solvents, including…”

Section: Chitosanmentioning

confidence: 99%

Bioactive Chitosan Nanoparticles and Photodynamic Therapy Inhibit Collagen Degradation In Vitro

Persadmehr

Torneck

Cvitkovitch

et al. 2014

Journal of Endodontics

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This study evaluated the ability of photodynamic therapy (PDT), chitosan nanoparticles (CSnp), or their combination, to inhibit bacterial collagenase-mediated degradation of collagen. Rat type 1 fibrillar collagen matrices were untreated or treated with 2.5% glutaraldehyde (GD), 2.5% GD followed by 1% CSnp, 1% CSnp, PDT, or 1% CSnp followed by PDT. Samples, except untreated controls, were exposed to Clostridium histolyticum collagenase. The soluble digestion products were assessed by hydroxyproline assay and the remaining adherent collagen was quantified by picrosirius red (PSR) staining. Collagen treated with CSnp, PDT, or a combination of CSnp and PDT, exhibited less degradation than controls. The abundance of post-treatment residual collagen correlated with the extent of degradation. Fourier transform infrared (FTIR) spectroscopy analysis showed that PDT treatment enhanced collagen cross-linking.Immunoblotting of sedimented CSnp indicated that CSnp and collagenase bound with low affinity. However, CSnp-bound collagenase showed a significant reduction in collagenolytic activity compared with controls.III

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Antibacterial and mechanical properties of bone cement impregnated with chitosan nanoparticles

Cited by 355 publications

References 36 publications

Antibacterial iodine-supported titanium implants

Antibacterial iodine-supported titanium implants

Prevention of pin tract infection with iodine-supported titanium pins

Bioactive Chitosan Nanoparticles and Photodynamic Therapy Inhibit Collagen Degradation In Vitro

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