Antibacterial and phytochemical analysis of traditional medicinal plants: An alternative therapeutic Approach to conventional antibiotics

Asfaw, Asaye; Lulekal, Ermias; Bekele, Tamrat; Debella, Asfaw; Meresa, Asfaw; Sisay, Bihonegn; Degu, Sileshi; Abebe, Abiy

doi:10.1016/j.heliyon.2023.e22462

Cited by 3 publications

(2 citation statements)

References 29 publications

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“…Overharvesting of multipurpose medicinal plant species for medicinal use, agricultural tools and firewood purposes was the major factor in the decline of the species in SMNP. Previous authors [ 23 , 29 , 46 ] also disclosed that overharvesting of multipurpose medicinal plants for different purposes fastens the depletion of plant species in different regions of Ethiopia. According to [ 23 ], a plant's use diversity indicates how frequently it is used, which contributes to its decline in the area.…”

Section: Resultsmentioning

confidence: 99%

Traditional lore on the healing effects of therapeutic plants used by the local communities around Simien Mountains National Park, northwestern Ethiopia

Seraw,

Melkamu,

Masresha

2024

J Ethnobiology Ethnomedicine

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Background Simien Mountain National Park is a world heritage site with spectacular landscapes and rich in floral diversity. Exploring the plethora of conventional wisdom regarding therapeutic flora for sustainable use and drug development is a timely endeavor. Thus, the present study was aimed at investigating therapeutic plant uses and conservation practices by the local communities dwelling in the vicinity of the Park. Methods Eighty randomly selected general informants and 20 purposefully selected key informants were used to collect the traditional lore from 10 purposefully selected kebeles that border the Park. Data were collected using face-to-face interviews, guided field walks, group discussions and market surveys. Descriptive statistics were used to analyze the basic information collected from the informants. An independent sample t test was computed to compare the knowledge variations among different informant groups. Clustering and ranking techniques were employed to validate traditional wisdom of informants. Results Significant differences in traditional wisdom (P < 0.05) were observed only between general and key informants. Hundred thirteen therapeutic plant species belonging to 56 families were recorded. Asteraceae was the most species-rich family (10%). The majority of therapeutic species were collected from the wild (77%). Herbs and roots were the most preferred habit (47%) and plant parts (37%) for remedy preparation, respectively. Pounding was the most common preparation method (50.1%). The most frequently practiced route of administration was the oral route (48.1%). The highest Informant Consensus Factor (ICF) value (84%) was recorded for respiratory and febrile illnesses. Rumex nepalensis was the most preferred for the treatment of wounds, and Olea europaea subsp cuspidata was the first-ranked multipurpose plant. Conclusion The Park is rich in therapeutic species serving as a refuge for many endemic and endangered species associated with the local community rich medicinal traditional lore. Erosion of therapeutic plants, verbal transfer of the traditional wisdom and young generation negligence in acquiring traditional lore led to the deterioration of the long tradition of using therapeutic plants for health care. Endangered multipurpose therapeutic plants like Echinops kebericho should get conservation priority. Therapeutic plants with the highest ICF and fidelity level could be candidates for drug development.

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Section: Resultsmentioning

confidence: 99%

Traditional lore on the healing effects of therapeutic plants used by the local communities around Simien Mountains National Park, northwestern Ethiopia

Seraw,

Melkamu,

Masresha

2024

J Ethnobiology Ethnomedicine

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“…Numerous therapeutic herbs are known for their antibacterial (Degu et al, 2021a;Gonfa et al, 2022;Legesse et al, 2022;Asfaw et al, 2023b;Dagne et al, 2023), antifungal (Degu et al, 2020b), antiviral (Meresa et al, 2017;Tesera et al, 2022), anti-parasitic (Basha et al, 2018;Muluye et al, 2021), anti-hypertensive (Fekadu et al, 2017), anti-asthmatic (Sisay et al, 2020), insect repellent (Degu et al, 2020a), and so on effects. They are utilized as a food source in addition to their medical properties (Olowoyeye et al, 2022).…”

Section: Introductionmentioning

confidence: 99%

Vernonia amygdalina: a comprehensive review of the nutritional makeup, traditional medicinal use, and pharmacology of isolated phytochemicals and compounds

Degu,

Meresa,

Animaw

et al. 2024

Front. Nat. Prod.

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Vernonia amygdalina is a perennial shrub that belongs to the family Asteraceae. The herb is an indigenous African plant that grows in most parts of sub-Saharan Africa. It is probably the most used medicinal plant in the genus Vernonia. Previous studies on the traditional medicinal value, nutritional composition, classes of phytochemical or compound isolation, and evaluation of their pharmacology activity are numerous. This provokes us to review and provide up-to-date evidence-based information on the study plant. A systematic online search using the databases of Google Scholar, PubMed, Science Direct, Wiley, Elsevier and Sci-Hub was carefully applied, using some important key words to get appropriate information. The leafy part of Vernonia amygdalina contributes greatly to the nutritional requirements for human health and to food security since it contains enough concentrations of proximate composition, minerals, and vitamins. The plant parts are used in traditional medicine for many human and animal healthcare purposes, including diarrhea, diabetes, wound healing, tonsillitis, evil eye, retained placenta, headache, eye disease, intestinal parasite, bloating, hepatitis, toothache, anthrax, malaria, urine retention, gastritis, stomach disorders, and snake bites. The chemical analysis revealed the presence of flavonoids, alkaloids, saponins, tannins, triterpenoids, sesquiterpene lactones, steroids, cardiac glycosides, oxalates, phytates, cyanogenic glycosides, and phenols. Additionally, various compounds such as vernolide, luteolin, vernodalol, vernoamyoside A, vernoamyoside B, isorhamnetin, glucuronolactone, and 1-Heneicosenol O-β-D-glucopyranoside were isolated. Some of the isolated compounds pharmacological activity was evaluated against some diseases and showed antioxidant, antibacterial, antifungal, antihelmintic, anticancer, and anti-inflammatory potencies. Thus, the review provides comprehensive information about ethnomedicinal value, nutritional composition, isolated classes of phytochemicals, and compounds, including an evaluation of the pharmacological activity of the isolated compounds of Vernonia amygdalina. A review with this much information could be extremely valuable for future research on developing innovative nutraceutical products.

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Efficacy of medicinal plants in cryptosporidiosis treatment: a comprehensive review

Thakur,

Yadav,

Kaur

et al. 2024

J Parasit Dis

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Antibacterial and phytochemical analysis of traditional medicinal plants: An alternative therapeutic Approach to conventional antibiotics

Cited by 3 publications

References 29 publications

Traditional lore on the healing effects of therapeutic plants used by the local communities around Simien Mountains National Park, northwestern Ethiopia

Traditional lore on the healing effects of therapeutic plants used by the local communities around Simien Mountains National Park, northwestern Ethiopia

Vernonia amygdalina: a comprehensive review of the nutritional makeup, traditional medicinal use, and pharmacology of isolated phytochemicals and compounds

Efficacy of medicinal plants in cryptosporidiosis treatment: a comprehensive review

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