Antibacterial Anthraquinone Derivatives from a Sea Anemone-Derived Fungus <i>Nigrospora</i> sp.

Yang, Kai-Lin; Wei, Mei‐Yan; Shao, Chang‐Lun; Fu, Xiaojian; Guo, Zhiyong; Xu, Ru-Fang; Zheng, Cai‐Juan; She, Zhigang; Lin, Yongcheng; Wang, Chang‐Yun

doi:10.1021/np300103w

Cited by 79 publications

(70 citation statements)

References 16 publications

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“…(TA26-9) and their structure-activity relationships were also discussed. More importantly, 3-acetoxy-4-deoxybostrycin exhibited a promising activity against B. cereus with an MIC value of 48.8 nM, which was stronger than that of the positive control ciprofloxacin (MIC 1,250 nM) (Yang et al 2012). Moreover, a series of 14-membered resorcylic acid lactones (RALs), including three new metabolites, cochliomycins isolated from the gorgonian-derived fungus Cochliobolus lunatus, was also recently isolated from a zoanthid-derived Cochliobolus sp.…”

Section: Discussionmentioning

confidence: 90%

Phylogenetic Diversity and Antibacterial Activity of Culturable Fungi Derived from the Zoanthid Palythoa haddoni in the South China Sea

Qin

Yang

et al. 2014

Mar Biotechnol

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Investigation on diversity of culturable fungi mainly focused on sponges and corals, yet little attention had been paid to the fungal communities associated with zoanthid corals. In this study, a total of 193 culturable fungal strains were isolated from the zoanthid Palythoa haddoni collected in the South China Sea, of which 49 independent isolates were identified using both morphological characteristics and internal transcribed spacer (ITS) sequence analyses. Thirty-five strains were selected for phylogenetic analysis based on fungal ITS sequences. The results indicated that 18 genera within eight taxonomic orders of two phyla (seven orders of the phylum Ascomycota and one order of the phylum Basidiomycota) together with one unidentified fungal strain have been achieved, and Cladosporium sp. represented the dominant culturable genus. Particularly, 14 genera were isolated from a zoanthid for the first time. The antibacterial activities of organic extracts of mycelia and fermentation broth of 49 identified fungi were evaluated, and 29 (59.2 %) of the isolates displayed broad-spectrum or selective antibacterial activity. More interestingly, more than 60 % of the active fungal strains showed strong activity against two aquatic pathogenic bacteria Nocardia brasiliensis and Vibrio parahaemolyticus, compared with other pathogenic bacteria, indicating that zoanthid-derived fungi may protect its host against pathogens. This is the first report of systematically phylogenetic diversity and extensively antibacterial activity of zoanthid-derived fungi.

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Section: Discussionmentioning

confidence: 90%

Phylogenetic Diversity and Antibacterial Activity of Culturable Fungi Derived from the Zoanthid Palythoa haddoni in the South China Sea

Qin

Yang

et al. 2014

Mar Biotechnol

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“…12A35 [55]; a new cyclopeptide marthiapeptide A ( 44 ), isolated from the South China Sea-derived bacterium Marinactinospora thermotolerans [56]; two known napyradiomycin A1 ( 45 ) and napyradiomycin B3 ( 46 ) from a Chinese marine-derived Streptomyces sp. strain SCSIO [57,58]; two new hydroanthraquinone analogues 4a- epi -9α-methoxydihydrodeoxybostrycin ( 47 ) and 10-deoxy-bostrycin ( 48 ), isolated from a South China Sea marine-derived fungus Nigrospora sp., isolated from an unidentified sea anemone [59]; a novel cyclic peptide ohmyungsamycin A ( 49 ) from a Korean Streptomyces sp. strain SNJ042 [60]; and a novel benzofuran penicifuran A ( 50 ), obtained from a South China Sea sponge-derived fungus Penicillium sp.…”

Section: Marine Compounds With Antibacterial Antifungal Antiprotmentioning

confidence: 99%

Marine Pharmacology in 2012–2013: Marine Compounds with Antibacterial, Antidiabetic, Antifungal, Anti-Inflammatory, Antiprotozoal, Antituberculosis, and Antiviral Activities; Affecting the Immune and Nervous Systems, and Other Miscellaneous Mechanisms of Action

et al. 2017

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The peer-reviewed marine pharmacology literature from 2012 to 2013 was systematically reviewed, consistent with the 1998–2011 reviews of this series. Marine pharmacology research from 2012 to 2013, conducted by scientists from 42 countries in addition to the United States, reported findings on the preclinical pharmacology of 257 marine compounds. The preclinical pharmacology of compounds isolated from marine organisms revealed antibacterial, antifungal, antiprotozoal, antituberculosis, antiviral and anthelmitic pharmacological activities for 113 marine natural products. In addition, 75 marine compounds were reported to have antidiabetic and anti-inflammatory activities and affect the immune and nervous system. Finally, 69 marine compounds were shown to display miscellaneous mechanisms of action which could contribute to novel pharmacological classes. Thus, in 2012–2013, the preclinical marine natural product pharmacology pipeline provided novel pharmacology and lead compounds to the clinical marine pharmaceutical pipeline, and contributed significantly to potentially novel therapeutic approaches to several global disease categories.

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“…The developing zebrafish ( Danio rerio ) is an in vivo developmental model with a number of advantages over in vitro systems and provides a simple, inexpensive and rapid assay to screen for teratogenicity [4,5]. As part of our ongoing investigation into new natural metabolites, a series of antibacterial, antifouling and cytotoxic products have been isolated from marine fungi from the South China Sea [6,7,8,9]. Under the guidance of zebrafish embryo teratogenicity assay, a new chlorinated benzophenone derivative, (±)-pestalachloride D ( 1 ), along with one related known analogue, (±)-pestalachloride C ( 2 ) [10] (Figure 1), was obtained from the organic extracts of the marine-derived fungus Pestalotiopsis sp.…”

Section: Introductionmentioning

confidence: 99%

(±)-Pestalachloride D, an Antibacterial Racemate of Chlorinated Benzophenone Derivative from a Soft Coral-Derived Fungus Pestalotiopsis sp.

Wei

Shao

et al. 2013

Marine Drugs

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A new antibacterial chlorinated benzophenone derivative, (±)-pestalachloride D (1), along with a related analog, (±)-pestalachloride C (2), was recently isolated from the marine-derived fungus Pestalotiopsis sp. isolated from a soft coral Sarcophyton sp. collected from Yongxing Island in the South China Sea. Both chiral HPLC analysis and single-crystal X-ray data indicated that 1 is a racemic mixture. Interestingly, 1 did not exhibit any effect in the zebrafish embryo teratogenicity assay, while 2 led to abnormal growth. The potential impact on zebrafish embryo growth is discussed based on their crystal structures. The main difference of crystal structures between 1 and 2 is that the six-member non-aromatic ring (O4, C10, C9, C8, C2′, and C3′) in 1 exhibits a distorted chair conformation, while 2 shows a distorted boat conformation. Moreover, compounds 1 and 2 both exhibited moderate antibacterial activity.

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Antibacterial Anthraquinone Derivatives from a Sea Anemone-Derived Fungus Nigrospora sp.

Cited by 79 publications

References 16 publications

Phylogenetic Diversity and Antibacterial Activity of Culturable Fungi Derived from the Zoanthid Palythoa haddoni in the South China Sea

Phylogenetic Diversity and Antibacterial Activity of Culturable Fungi Derived from the Zoanthid Palythoa haddoni in the South China Sea

Marine Pharmacology in 2012–2013: Marine Compounds with Antibacterial, Antidiabetic, Antifungal, Anti-Inflammatory, Antiprotozoal, Antituberculosis, and Antiviral Activities; Affecting the Immune and Nervous Systems, and Other Miscellaneous Mechanisms of Action

(±)-Pestalachloride D, an Antibacterial Racemate of Chlorinated Benzophenone Derivative from a Soft Coral-Derived Fungus Pestalotiopsis sp.

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