Antibacterial, antioxidant and antidiabetic activities of Gmelina arborea roxb fruit extracts

Nayak, BhabaniShankar; Ellaiah, P; Dinda, Subas Chandra

doi:10.4103/0973-8258.104937

Cited by 15 publications

(19 citation statements)

References 9 publications

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“…For diabetes Gmelina arborea Roxb. (Nayak et al 2013), Marrubium vulgare L. (Boudjelal et al 2011), Salvia hispanica L. (Munoz et al 2013) have proven to be effective, while Salvia elegans Vahl. (Jimenez et al 1988), thymus capitatus (L.) Hoffmanns & Link (Yvon et al 2012), Salvia hispanica L. (Mihailovic-Stanojevic et al 2013), and thymus serpyllum L. (Jovanovic et al 2005) can be used for hypertension.…”

Section: Medicinal Plants Of the Family Lamiaceaementioning

confidence: 99%

Medicinal plants of the family Lamiaceae as functional foods - a review

Carović‐Stanko¹,

Petek²,

Grdiša³

et al. 2016

Czech J. Food Sci.

180

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Carović-Stanko K., Petek M., Grdiša M., Pintar J., Bedeković D., Herak Ćustić M., Satovic Z. (2016) Historically, species of the family Lamiaceae have enjoyed a rich tradition of use for flavouring, food preservation, and medicinal purposes, due to both their curative and their preventive properties. It is well known that each species has a special, complex mixture of bioactive compounds in which each component contributes to its overall bioactivity. Their value lays in the production of a wide range of secondary metabolites with potent antibacterial, antioxidant, anti-inflammatory, antimicrobial, antiviral, and anticancer activities. This review focuses on the Lamiaceae species and their secondary metabolites encompassing a wide array of beneficial functions and their applicability as sources of functional foods. It could help in addressing specific consumer needs as healthy diet is a part of the lifestyle that maintains or improves overall health.

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Section: Medicinal Plants Of the Family Lamiaceaementioning

confidence: 99%

Medicinal plants of the family Lamiaceae as functional foods - a review

Carović‐Stanko¹,

Petek²,

Grdiša³

et al. 2016

Czech J. Food Sci.

180

View full text Add to dashboard Cite

show abstract

“…In addition to its vasoactive activity, other possible mechanisms could be involved in the effect of G. arborea. Thus, diuretic activity of G. arborea fruit extracts has been reported (Nayak et al, 2013).…”

Section: Resultsmentioning

confidence: 99%

Effects of Gmelina arborea, Roxb (Verbenaceae) aqueous extract on arterial pressure of Wistar rats

Lawson¹,

Awede²,

Osseni³

et al. 2016

J. Physiol. Pathophysiol.

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In this study, the effect of Gmelina arborea aqueous extract, a medicinal plant used in the treatment of hypertension, on rat blood pressure was investigated. After harvest, leaves of G. arborea were dried, reduced in powder and used for aqueous extract preparation. The aqueous extract was administrated at 500 mg/kg/day to Wistar rats, which has been made hypertensive by NG-Nitro-L-arginine methyl ester (L-NAME), treatment at 20 mg/kg/day. Alkaloid compounds, tannins, anthocyanins, leucoanthocyanins, mucilages and saponins were detected in G. arborea leaves. 7 and 14 days administration of L-NAME induced an increase of mean arterial blood pressure from 99±4 mmHg to respectively 155±2 and 179±10 mmHg. G. arborea leaves extract reduced these blood pressures to respectively 126±13 and 147±7 mmHg. These data confirm the antihypertensive effect of G. arborea leaves. Further investigations will analyze the active compounds and the molecular mechanisms underlying this pharmacological effect.

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“…Fruit size is drup 2.25 cm long and contains 1-4 seeds. Literature information has shown extracts of G. arborea exhibited anti-inflammation [1], antihypertensive effect [2], anti-oxidative stress [3], antibacterial, antioxidant [4,5] and antidiabetic [5,6] activities. In addition, the immunostimulant potential of extract of G. arborea has been reported [7].…”

Section: Introductionmentioning

confidence: 99%

Anti-nociceptive and Anti-inflammatory Effects of Gmelina arborea Roxb. e x. Sm.

Adebayo¹

2018

Invest Med Chem Pharmacol

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Background: The aim of the present study was to evaluate the anti-inflammatory and anti-nociceptive activities of the methanolic extract of Gmelina arborea fruit (GAF) and stem bark (GASB) on egg-albumin induced inflammation and heated plate metal respectively. Methods: 500 g of each of the pulverised samples was extracted with 90% methanol using soxhlet extractor to produce dense mass of methanolic extracts after distillation and kept in a refrigerator at 4 o C until further analysis. The anti-inflammatory activity was determined on fresh egg albumins over 4 h by measurement of rat paw oedema according to established procedure. The anti-nociceptive was evaluated by placing each rat on the heated metal plate (Hot plate) maintained at the temperature of about 50-55 0 C within the restraining plastic cylinder while animals responses were taken over 90 min. Results: Methanolic extracts of G. arborea yielded blackish thick mass and greenish paste viscous extract for the GASB and GAF respectively with percentage yields of 28% and 30% respectively. The yield revealed more extractives in the GAF than GASB. The anti-nociceptive properties of both GAF and GASB shows a relatively time dependent activity as rate of inhibition was high at the 30 th min (at the peak of p<0.001) for all doses except for 100 mg/kg per oral for the GAF. At increased time, the activity of most of the extracts reduced considerably. The eggalbumin induced inflammation was inhibited by the extracts as well in different doses. There were considerable inhibition for the GAF as well as the GASB at a minimum significant value of p<0.05 from the 1 st h to the 4 th h with maximum percentage inhibition (PI) values ranging between 30% to a peak of 70% when compared to the control. The methanolic extract of G. arborea fruit and stem bark showed significant (p<0.05) anti-inflammatory activity. Conclusions: This study has shown that GASB and GAF displayed significant anti-inflammatory effect on paw oedema induced by egg-albumin by inhibiting the release of mediators for the entire 4 h experimental period. The anti-nociceptive actions were also significant when compared with the control.

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Antibacterial, antioxidant and antidiabetic activities of Gmelina arborea roxb fruit extracts

Cited by 15 publications

References 9 publications

Medicinal plants of the family Lamiaceae as functional foods - a review

Medicinal plants of the family Lamiaceae as functional foods - a review

Effects of Gmelina arborea, Roxb (Verbenaceae) aqueous extract on arterial pressure of Wistar rats

Anti-nociceptive and Anti-inflammatory Effects of Gmelina arborea Roxb. e x. Sm.

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