Antibacterial, Antioxidant, and Cytotoxic Flavonoid Compound from Sterculia Quadrifida Leaves

Abstract

The genus Sterculia generally grows in the tropics and sub-tropics. 1 the genus had many secondary metabolites such as alkaloids, saponins, triterpenoids, tannins, and phenolics. 2 Several species in this genus are traditionally used to treat ulcers, diarrhoea, fever, stroke, diabetes, and inflammation. 3 Sterculia quadrifida, a plant called "Faloak" in Indonesia, has a significant role in folk medicine, especially for infectious diseases, as anti-hepatitis, and anticancer. 4 However, studies of S. quadrifida plants are still limited. Only a few studies have been conducted in the last decade investigating the phytochemical content of S. quadrifida plants and isolating triterpenoids and anthraquinone compounds. 5,6 Some of these compounds show pharmacological effects, such as anti-hepatitis 7 , immunostimulant, antioxidant, anti-cancer, and antibacterial activities. 7-9 Among all compounds, flavonoids have the potential to be used as anti-infective, antioxidant, and anti-cancer agent. 10 Therefore, this study aimed to isolate the active antibacterial, antioxidant, and anti-cancer compounds from the methanol leaves extract of S. quadrifida using chromatographic techniques.