Antibacterial, Antioxidant, Chemical Constituents, and Cytotoxicity Evaluation of Terminalia Arjuna (Roxb. Ex Dc.) Wight and Arn

Khatri, Savita; Phougat, Neetu; Dangi, Mehak; Chhillar, Anil Kumar

doi:10.22159/ajpcr.2017.v10i3.16408

Cited by 4 publications

(4 citation statements)

References 13 publications

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“…The bark powder has been discovered to have a wide range of therapeutic qualities. Various phytoconstituents including arjunin, arjunic acid, qudranoside VIII, terminarjunoside I and II, luteolin, baicalein, kempferol, oligomeric proanthocyanidins, pelargonidin, quercetin, β-sitosterol, hentriacontane, methyl oleaolate, and myristyl oleate are obtained from stem bark, root, and fruits of T. arjuna ( Khatri et al, 2017 ). Eucalyptus camaldulensis , on the other hand, has been utilized as an antibacterial agent in a variety of illnesses ( Shagal et al, 2012 ).…”

Section: Introductionmentioning

confidence: 99%

Green synthesized silver nanoparticles: Optimization, characterization, antimicrobial activity, and cytotoxicity study by hemolysis assay

et al. 2022

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Green nanotechnology has emerged as a viable option for the production of nanoparticles. The purpose of the current investigation was to synthesize silver nanoparticles (AgNPs) using Eucalyptus camaldulensis and Terminalia arjuna extracts, as well as their combinations, as green reducing and capping agents. The parameters (concentration of silver nitrate solution and plant extract, time, pH, and temperature) were optimized for maximal yields, regulated size, and stability of silver nanoparticles. The ultraviolet–visible spectrophotometer (UV-Vis) and the surface plasmon resonance band (SPR) were used to validate the synthesis of AgNPs. The size, shape, and stability of nanoparticles were assessed using a zeta analyzer and a scanning electron microscope (SEM). The biomolecules responsible for the reduction of silver ion (Ag+) and the stability of silver nanoparticles generated with the plant extracts were identified using Fourier-transform infrared spectroscopy (FTIR). The agar-well diffusion method was used to test the antimicrobial activity of biosynthesized nanoparticles against Bacillus subtilis, Staphylococcus aureus, Pasteurella multocida, and Escherichia coli. When 1 mM of silver nitrate (AgNO3) was added to plant extracts and incubated for 60 min at 75°C in a neutral medium, maximum nanoparticles were produced. Biosynthesized silver nanoparticles were stable, spherical, and monodispersed according to zeta potential and scanning electron microscopy. Silver nanoparticles synthesized with combination 2 and T. arjuna showed the highest zone of inhibition (16 mm) against B. subtilis while combination 3 showed the largest zone of inhibition against S. aureus (17 ± 0.8). It was concluded that greenly produced silver nanoparticles showed good antibacterial activity while causing negligible cytotoxicity.

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Section: Introductionmentioning

confidence: 99%

Green synthesized silver nanoparticles: Optimization, characterization, antimicrobial activity, and cytotoxicity study by hemolysis assay

et al. 2022

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“…Numerous beneficial substances, including phenol, flavones, monoterpene, triterpenes, stigmasterol, cineol, campesterol, lupeol, artemisinin etc. are present in the essential oils extracted from the leaves (9,43,44).…”

Section: Phytochemical Compositionsmentioning

confidence: 99%

“…The essential oils extracted from B. lacera leaves have been found to contain various bioactive molecules, including flavonoids and terpenes (9). Reports suggest that the plant's methanolic leaf extract (PMLE) possesses diverse properties such as antifungal, bactericidal, cytotoxic, febrifuge, antiviral, antileukemic and antidiarrheal activities (10).…”

Section: Introductionmentioning

confidence: 99%

Blumea lacera (Burm.f.) DC: A review on ethnobotany, phytochemistry, ancient medicinal and pharmacological Uses

Sinha,

Banerjee,

Majgaonkar

et al. 2024

Plant Sci. Today

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Blumea lacera (Burm.f.) DC., a member of the Asteraceae family, is an annual herbaceous plant with a rich array of phytochemicals that hold immense therapeutic promise. Commonly known as Karanda jangli muli (in Hindi) and kukkuradru (in Sanskrit), this herb is cultivated for its applications in food, essential oil extraction and various ethnomedical purposes. It thrives in diverse regions, including the Indian plains, the northwest Himalayas, China, Tropical Africa, the Malay Islands, Australia, Ceylon and Malaya. B. lacera boasts a multitude of valuable phytochemical components, including alpha-amyrin, ß-sitosterol, acetates, hentriacontane, stigmasterol, lupeol and lupeol acetate. These phytochemicals exhibit a wide range of pharmacological properties such as antipyretic, anti-inflammatory, anthelmintic, diuretic, antidiarrheal, antimicrobial, cytotoxic, astringent, hepatoprotective, sedative, anxiolytic, anti-viral, analgesic, hypothermic, anti-bacterial, anti-atherothrombotic, anti-leukemic and tranquilizing effects. Additionally, the phytochemicals derived from B. lacera align with various Ayurvedic attributes, encompassing dravya (substance), rasa (taste), guna (qualities), veerya (potency), vipaka (post-digestion outcome), karma (pharmacological actions) and prabha (therapeutics). Despite the plant's extensive bioactive chemical profile and therapeutic significance, scientific studies on B. lacera remain surprisingly scarce. In light of its numerous applications, this review aims to elucidate the diversity of phytochemicals, ethnomedicinal uses and therapeutic potentials of B. lacera.

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“…12,13 Many useful phytoconstituents have been isolated from Terminalia arjuna which included triterpenoids for cardiovascular properties, tannins and flavonoids for its anticancer, antimicrobial properties and so on. 14…”

Section: Introductionmentioning

confidence: 99%

Development and Characterization of Terminalia arjuna Phospholipid Complex and Its Tablet Formulation by Qbd Approach

Saudagar¹,

Sidram²,

Baburo³

et al. 2022

Int J Life Sci Pharm Res

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Phytosomes are a newly introduced novel drug delivery system and novel botanical formulation to induce lipophilic molecular complexes to enhance absorption and bioavailability of phytoconstituents. Terminali aarjuna phospholipid complex and it’s tablet formulations targeted for cardiovascular systems was prepared. Our study aims is for improving the cardioprotective activity by formulating Terminalia arjuna phospholipid complex tablet by using solvent evaporation method. and characterized by various parameters like solubility studies, particle size determination, infrared absorption (FTIR), Scanning electron microscopy (SEM), entrapment efficiency etc. as well as by applying QbD approach various general characteristics such as entrapment efficiency etc were also done. A QbD- based approach using a Box-Behnken design was done to obtain a response surface design expert software 9.0.5 to systematically study the combined influence of the formulation and process variables such as the phospholipids-drug ratio(X1, w/w), the reaction temperature(X2, °C), and the reaction time (X3, hrs) on a critical quality attributes (CQAs) of the product i.e., the entrapment efficiency. Using this design, the experimental trials were carried out at all 15 possible combinations. The preliminary investigation of the influence of factors revealed that all the tested variables, i.e., the phospholipids to drug ratio, the reaction temperature and the reaction time had a significant influence on the entrapment efficiency of the prepared phytosomes. The study revealed that the entrapment efficiency of Terminalia arjuna Phytosomes was found to be 83.0-97.9 %w/w.

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Antibacterial, Antioxidant, Chemical Constituents, and Cytotoxicity Evaluation of Terminalia Arjuna (Roxb. Ex Dc.) Wight and Arn

Cited by 4 publications

References 13 publications

Green synthesized silver nanoparticles: Optimization, characterization, antimicrobial activity, and cytotoxicity study by hemolysis assay

Green synthesized silver nanoparticles: Optimization, characterization, antimicrobial activity, and cytotoxicity study by hemolysis assay

Blumea lacera (Burm.f.) DC: A review on ethnobotany, phytochemistry, ancient medicinal and pharmacological Uses

Development and Characterization of Terminalia arjuna Phospholipid Complex and Its Tablet Formulation by Qbd Approach

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