Antibacterial applications and safety issues of silica‐based materials: A review

Abstract

As the problem of bacterial contamination continues to grow in its significance, researchers have reported many antibacterial materials that are based on inorganic compounds. Of these, materials that are based on silica and its derivatives have been widely used in engineering, medicine, and food. This paper reviews the advantages, safety issues, and applications of silica and its derivatives, as reported in recent years. The information provided highlights the preparation, application, and antimicrobial efficiency of materials that are based on silica and have different structure/size. We outline the possible antimicrobial mechanisms of silica‐based materials and the potential challenges that researchers may face. With a focus on increasing concerns regarding bacterial contamination in the food and medical industries, we have also proposed corresponding antibacterial material preparation strategies.

Comparison of the antimicrobial photocatalytic activities of SiO2 and Au@SiO2 nanostructures in water decontamination

“…The thickness of the inhibition zone for 20, 40, and 80 μg/mL concentrations were obtained, 0, 7.77, and 8.44 mm, respectively. Appeared halos around the filter paper disks should be due to the interaction between nanoparticles and bacterial surface proteins in such a way that, it can change the properties of proteins on the surface of bacteria and inhibit the growth of bacterial cells (Tian & Liu, 2020). In the following, antibacterial ability of Au@SiO 2 nanostructures was investigated and the results were compared with the ability of bare SiO 2 nanoparticles.…”

“…A number of rare earth metal oxides have been reported to possess strong antibacterial potentials against multiple drug resistance bacterial strains (Arshad et al, 2019;Rabiee et al, 2022). In this regard herein, antibacterial activity of silica and Au@SiO 2 has been specially the filter paper disks should be due to the interaction between nanoparticles and bacterial surface proteins in such a way that, it can change the properties of proteins on the surface of bacteria and inhibit the growth of bacterial cells (Tian & Liu, 2020). In the following, antibacterial ability of Au@SiO 2 nanostructures was investigated and the results were compared with the ability of bare SiO 2 nanoparticles.…”

Antibacterial and Wound-Healing Activities of Statistically Optimized Nitrofurazone- and Lidocaine-Loaded Silica Microspheres by the Box–Behnken Design

“…In order to kill bacteria, the drug must be able to cross the cell membrane and enter the bacteria to produce its effect. In the literature, it has been hypothesized that the silica interact with certain proteins present on the surface of bacteria and thus may open some channels on the surface which cause the drug substance to enter smoothly inside bacteria, thereby killing them [35]. Similarly, some researchers simply proposed that the combination of the antibacterial agent with SiO 2 may have a synergistic effect on killing bacteria [36].…”

Antireflective, Transparent, Water-Resistant, and Antibacterial Zn-Doped Silicon Oxide Thin Films for Touchscreen-Based Display Applications

“…In addition, large numbers of swipes or touches on the screen cause poor mechanical durability of metal nanoparticles on the display, owing to their weak adhesion. Many recent studies have revealed the antibacterial activity of various metal oxide nanoparticles such as ZnO, CuO, TiO 2 , and Fe 2 O 3 . − However, metal oxide nanoparticles prepared using a solution method usually display inhomogeneous antibacterial effect and lowered transmittance due to the severe agglomeration of the nanoparticles, whereas metal oxide thin films prepared by sputtering exhibit excellent antibacterial activity and mechanical durability …”