Antibacterial Benzofuran Neolignans and Benzophenanthridine Alkaloids from the Roots of<i>Zanthoxylum capense</i>

Luo, Xuan; Pedro, Liliana; Milic, Vladimir; Mulhovo, Silva; Duarte, Aida; Duarte, Noélia; Ferreira, Maria‐José U.

doi:10.1055/s-0031-1280289

Cited by 31 publications

(13 citation statements)

References 25 publications

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“…The bioactive compounds responsible for the observed effects have not been properly characterized and the mechanism of activity has not been explored. In the case of Z. capense, biological activities such as anti-mycobacterial [ 50 ] and anti-proliferative effects [ 51 ] have been reported, subsequent to a bio-assay guided isolation of six alkaloids from the roots of the plant [ 52 ].…”

Section: Resultsmentioning

confidence: 99%

The anti-inflammatory and antioxidant activity of 25 plant species used traditionally to treat pain in southern African

Adebayo

Dzoyem

Shai

et al. 2015

BMC Complement Altern Med

129

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BackgroundInflammation is a common risk factor in the pathogenesis of conditions such as infections, arthritis, type 2 diabetes mellitus, obesity and cancer. An ethnobotanical survey of medicinal plants used traditionally to treat inflammation and related disorders such as pain, arthritis and stomach aches in southern Africa led to the selection of 25 plant species used in this study.MethodsThe antioxidant activities of acetone extracts were determined by measuring the free radical scavenging activity and ferric reducing ability, respectively. The anti-inflammatory activities of the extracts were determined by measuring the inhibitory effect of the extracts on the activities of the pro-inflammatory enzyme, lipoxygenase and inducible nitric oxide synthase.ResultsExtracts of Peltophorum africanum had good antioxidant activity with IC50 values of 4.67 ± 0.31 μg/mL and 7.71 ± 0.36 μg/mL compared to that of the positive control ascorbic acid (2.92 ± 0.14 μg/mL and 13.57 ± 0.44 μg/mL), using the 2,2-diphenyl-1-picrylhydrazyl (DPPH) scavenging and 2,2′-azinobis (3-ethylbenzthiazoline-6-sulphonic acid (ABTS) methods, respectively. The metabolism of linoleic acid to leukotriene derivatives by 15-lipoxygenase (15-LOX) was also inhibited by the crude acetone extracts of Peltophorum africanum (IC50 = 12.42 μg/mL), Zanthoxylum capense (IC50 = 14.92 μg/mL) compared to the positive control quercetin (IC50 = 8.75 μg/mL). There was a poor correlation between the flavonoid content and 15-LOX inhibition by the extracts (R2 = 0.05), indicating that flavonoids are not involved in LOX inhibition. Extracts of Clausena anisata, at a concentration of 6.25 μg/mL inhibited nitric oxide production by RAW 264.7 macrophage cell lines in vitro by 96 %. The extracts of Zanthoxylum capense were the least cytotoxic (IC50 > 1000 μg/mL) when the extract toxicity was determined against Vero (African green Monkey) kidney cell lines.ConclusionSome plant species used traditionally to treat pain have reasonable anti-inflammatory activity and flavonoids are probably not involved in this process.

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Section: Resultsmentioning

confidence: 99%

The anti-inflammatory and antioxidant activity of 25 plant species used traditionally to treat pain in southern African

Adebayo

Dzoyem

Shai

et al. 2015

BMC Complement Altern Med

129

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“…Among them, benzophenanthridine alkaloids are particularly abundant in roots and stem bark (Krane et al 1984;Ng et al 1987;Hu et al 2006;Luo et al 2012), which have shown broad spectrum of biological activities, including cytotoxic, antiviral, antibacterial, antinociceptive, anti-inflammatory and insecticidal properties (Vanquelef et al 2004;Hu et al 2006;Ueno 2008;Obiang-Obounou et al 2011;Mansoor et al Research, 2015Vol. 29, No.…”

Section: Introductionmentioning

confidence: 99%

Cytotoxicity of benzophenanthridine alkaloids from the roots ofZanthoxylum nitidum(Roxb.) DC. var.fastuosumHow ex Huang

Wang

Fan

Tian

et al. 2015

Natural Product Research

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This work aimed to investigate benzophenanthridine from the roots of Zanthoxylum nitidum (Roxb.) DC. var. fastuosum How ex Huang for the first time. Thirteen benzophenanthridines were isolated, and our results of the cytotoxic activities indicated that compound 6 exhibited the best potency against A549, Hela, SMMC-7721 and EJ, with the IC50 values of 27.50, 37.50, 16.95 and 60.42 μM, respectively. Compounds 7 and 11 also showed strong cytotoxicity when tested against the four human cancer cell lines (A549, Hela, SMMC-7721 and EJ), while only compounds 12 and 13 displayed cytotoxicity in inhibiting BALL-1 proliferation among all the compounds. These results suggested that benzophenanthridines may become a valid alternative of potential basis for new anti-proliferative agents.

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“…17, hyndarine (18), (s)-canadine (19), isocorypalmine (20), and cheilanthifoline (21) were identified by comparison with NMR data in the literature. [17][18][19][20][21][22][23][24][25][26][27]…”

Section: Molecular Dockingmentioning

confidence: 99%

A Combined Phytochemical and Network Pharmacology Approach to Reveal the Effective Substances and Mechanism of Eomecon chionantha Hance for the Treatment of Ulcerative Colitis

Tian

Cheng

et al. 2021

Natural Product Communications

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Eomecon chionantha Hance (ECH), a traditional Chinese herbal medicine, has been reported for the treatment of traumatic injuries and colitis. The current treatments for ulcerative colitis (UC) are unstable and have side effects, so ECH is potentially useful for treating this condition. However, the active ingredients and pharmacological mechanisms of ECH in treating UC remain unclear. In this study, 21 alkaloids were extracted and purified from the roots of ECH, among which 13 were extracted from this herb for the first time. Our results showed that 12 ingredients may have effective pharmacological effects after absorption, distribution, metabolism, and excretion (ADME) screening. Network pharmacological analysis revealed that the active ingredients may have positive effects on 19 significant signaling pathways, such as on small cell lung cancer, serotonergic synapses, the IL-17 signaling pathway, Th17 cell differentiation, the estrogen signaling pathway, transcriptional misregulation in cancer, the PI3K-Akt signaling pathway, and others by targeting 23 proteins, including MAPK14, RXRA, GSK3B, CDK2, RXRB, HSP90AA1, PTGS2, and ESR1. It is of great benefit to use separation, purification, and network pharmacology together to screen active natural products. This study indicated potential anti-UC mechanisms of the active ingredients of ECH and provides theoretical support for the treatment of UC using ECH.

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Antibacterial Benzofuran Neolignans and Benzophenanthridine Alkaloids from the Roots ofZanthoxylum capense

Cited by 31 publications

References 25 publications

The anti-inflammatory and antioxidant activity of 25 plant species used traditionally to treat pain in southern African

The anti-inflammatory and antioxidant activity of 25 plant species used traditionally to treat pain in southern African

Cytotoxicity of benzophenanthridine alkaloids from the roots ofZanthoxylum nitidum(Roxb.) DC. var.fastuosumHow ex Huang

A Combined Phytochemical and Network Pharmacology Approach to Reveal the Effective Substances and Mechanism of Eomecon chionantha Hance for the Treatment of Ulcerative Colitis

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