Antibacterial Carbon Dots‐Based Composites

Abstract

The emergence and global spread of bacterial resistance to conventionally used antibiotics have highlighted the urgent need for new antimicrobial agents that might replace antibiotics. Currently, nanomaterials hold considerable promise as antimicrobial agents in anti‐inflammatory therapy. Due to their distinctive functional physicochemical characteristics and exceptional biocompatibility, carbon dots (CDs)‐based composites have attracted a lot of attention in the context of these antimicrobial nanomaterials. Here, a thorough assessment of current developments in the field of antimicrobial CDs‐based composites is provided, starting with a brief explanation of the general synthesis procedures, categorization, and physicochemical characteristics of CDs‐based composites. The many processes driving the antibacterial action of these composites are then thoroughly described, including physical destruction, oxidative stress, and the incorporation of antimicrobial agents. Finally, the obstacles that CDs‐based composites now suffer in combating infectious diseases are outlined and investigated, along with the potential applications of antimicrobial CDs‐based composites.

Biogenic carbon dots: a novel mechanistic approach to combat multidrug-resistant critical pathogens on the global priority list

“…14,15 In recent years, there has been a surge of interest in the use of various nanomaterials, such as anti-microbial peptides (AMPs), noble metal nanoparticles (such as Au NPs and Ag NPs), semiconductor nanoparticles, polymer nanostructures, and carbon-based nanomaterials (CNMs), for the management and eradication of bacterial infections, both in laboratory settings (in vitro) and in vivo. 16 AMPs are short-cationic and amphiphilic peptides renowned for their broad-spectrum antibacterial action, mainly through breaking microbial membranes, making bacteria resistant. 17 However, due to limitations such as in vivo protease hydrolysis, vigorous hemolytic activity against red blood cells, and high production costs, AMPs' therapeutic applicability is restricted.…”

“…The Food and Drug Administration (FDA) has approved less than sixty nanomedicines for intravenous delivery, underlining the need for increased understanding and management of noble metal structures in biomedical applications. 16 To investigate alternate methodologies, this study focuses on the mechanistic assessment of the anti-pathogenic activity of carbon dots (CDs) synthesized from F. benghalensis L. extracts. The biogenic CDs have demonstrated a broadspectrum anti-bacterial activity, even against multi-drug resistant (MDR) bacterial strains.…”

“…The Food and Drug Administration (FDA) has approved less than sixty nanomedicines for intravenous delivery, underlining the need for increased understanding and management of noble metal structures in biomedical applications. 16…”

Highly Antibacterial and Antioxidative Carbon Nanodots/Silk Fibroin Films for Fruit Preservation

“…In recent years, the introduction of biodegradable materials, such as starch-based materials, chitosan, cellulose, and proteins, has offered alternatives to petroleum-based plastics for food packaging. − Despite the potential benefits of these materials, they are still limited by their single function, poor flexibility, and low transparency. Carbon nanodots (CDs) are an emerging zero-dimensional functional material that have attracted a lot of attention due to remarkable luminescence, antimicrobial properties, and excellent biocompatibility. − Currently, CDs are serving their purpose in the food industry, including the detection of pesticides and additives. , CDs are also effective in scavenging pathogens as well as providing antioxidant activity, , suggesting their potential as additives in food preservation. Therefore, the exploration of CDs as safe additives for freshness preservation is expected to overcome the limitation of the current biobased packaging materials with singular functions.…”

“…pesticides and additives. 22,23 CDs are also effective in scavenging pathogens as well as providing antioxidant activity, 24,25 suggesting their potential as additives in food preservation. Therefore, the exploration of CDs as safe additives for freshness preservation is expected to overcome the limitation of the current biobased packaging materials with singular functions.…”