Antibacterial Character of Cationic Polymers Attached to Carbon-Based Nanomaterials

Plachá, Daniela; Muñoz‐Bonilla, Alexandra; Škrlová, Kateřina; Echeverría, Coro; Chiloeches, Alberto; Petr, Martin; Lafdi, Khalid

doi:10.3390/nano10061218

Cited by 21 publications

(12 citation statements)

References 50 publications

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“…Additionally, the incorporation of antifouling PEG prevented nonspecific cell attachment. Similarly, catechol was copolymerized with 2-(4-methylthiazol-5-yl) ethyl methacrylate (MTA) [ 49 ] and 2-(dimethylamino)ethyl methacrylate (DMAEMA) [ 50 ] to create cationic antimicrobial polymers.…”

Section: Catechol-modified Polymers With Innate Antimicrobial Propmentioning

confidence: 99%

Catechol-Based Antimicrobial Polymers

et al. 2021

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Catechol is a key constituent in mussel adhesive proteins and is responsible for strong adhesive property and crosslinking formation. Plant-based polyphenols are also capable of chemical interactions similar to those of catechol and are inherently antimicrobial. This review reports a series of catechol-based antimicrobial polymers classified according to their antimicrobial mechanisms. Catechol is utilized as a surface anchoring group for adhering monomers and polymers of known antimicrobial properties onto various types of surfaces. Additionally, catechol’s ability to form strong complexes with metal ions and nanoparticles was utilized to sequester these antimicrobial agents into coatings and polymer matrices. During catechol oxidation, reactive oxygen species (ROS) is generated as a byproduct, and the use of the generated ROS for antimicrobial applications was also introduced. Finally, polymers that utilized the innate antimicrobial property of halogenated catechols and polyphenols were reviewed.

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Section: Catechol-modified Polymers With Innate Antimicrobial Propmentioning

confidence: 99%

Catechol-Based Antimicrobial Polymers

et al. 2021

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“…The standard antibiotic Penicillin and Gentamicin were used as positive controls and distilled water as negative control in each replicate. The plates were incubated at 37 °C for 2 h under visible light and the dark environment for assessment of the antibacterial activity [ 67 , 68 ]; irradiation was performed under visible light (natural indoor light during the day and 100 W fluorescent lamps overnight) for a certain time.…”

Section: Methodsmentioning

confidence: 99%

Novel Pt-Ag3PO4/CdS/Chitosan Nanocomposite with Enhanced Photocatalytic and Biological Activities

et al. 2020

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Decorating photocatalysts with noble metal nanoparticles (e.g., Pt) often increases the catalysts’ photocatalytic activity and biomedical properties. Here, a simple and inexpensive method has been developed to prepare a Pt-Ag3PO4/CdS/chitosan composite, which was characterized and used for the visible light-induced photocatalytic and antibacterial studies. This synthesized composite showed superior photocatalytic activity for methylene blue degradation as a hazardous pollutant (the maximum dye degradation was observed in 90 min of treatment) and killing of Gram positive bacterial (Staphylococcus aureus and Bacillus cereus) as well as Gram negative bacteria (Klebsiella pneumoniae, Salmonella typhimurium, Escherichia coli, and Pseudomonas aeruginosa) under visible light irradiation. The antibacterial activity of CdS, CdS/Ag3PO4, and Pt-Ag3PO4/CdS/chitosan against E. coli, Pseudomonas aeruginosa, Salmonella typhimurium, Klebsiella pneumoniae, Staphylococcus aureus, and Bacillus cereus showed the zone of inhibition (mm) under visible light and under dark conditions at a concentration of 20 µg mL−1. Furthermore, the cell viability of the CdS/chitosan, Ag3PO4, Ag3PO4/CdS/chitosan, and Pt-Ag3PO4/CdS/chitosan were investigated on the human embryonic kidney 293 cells (HEK-293), Henrietta Lacks (HeLa), human liver cancer cell line (HepG2), and pheochromocytoma (PC12) cell lines. In addition, the results indicated that the photodegradation rate for Pt-Ag3PO4/CdS/chitosan is 3.53 times higher than that of CdS and 1.73 times higher than that of the CdS/Ag3PO4 composite. Moreover, Pt-Ag3PO4/CdS/chitosan with an optimal amount of CdS killed large areas of different bacteria and different cells separately in a shorter time period under visible-light irradiation, which shows significantly higher efficiency than pure CdS and other CdS/Ag3PO4 composites. The superb performances of this composite are attributed to its privileged properties, such as retarded recombination of photoinduced electron/hole pairs and a large specific surface area, making Pt-Ag3PO4/CdS/chitosan a valuable composite that can be deployed for a range of important applications, such as visible light-induced photocatalysis and antibacterial activity.

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“…The PLA granules have a density of 1.24 g/cm 3 , glass transition temperature (Tg) of 59 • C and melting point of 160 • C, molecular weight (MW) of 182,000 g/mol (Škrlová et al, 2022). Graphene oxide (GO) was prepared by a modified Hummers method (Plachá et al, 2020a). Concentrated H 2 SO 4 , KMnO 4 , graphite flakes, and concentrated H 2 O 2 were used for preparation of GO.…”

Section: Preparation Of Polylactide Compositesmentioning

confidence: 99%

Biocompatibility and biocidal effects of modified polylactide composites

et al. 2022

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Polylactide (PLA) materials treated with antimicrobial fillers represent a suitable alternative to the production of medical devices. Their advantage is that they can prevent the growth of microorganisms and the formation of microbial biofilms on the surface and around composites. The work is focused on the evaluation of biocompatibility and biocide effect of PLA composite films filled with vermiculite and graphene oxide modified with silver (Ag+ and Ag nanoparticles), hexadecylpyridinium (HDP) and hexadecyltrimethylammonium (HDTMA) cations and their degradation leachates monitored at 1–3–6-month intervals. The antimicrobial effect of the leachates was detected by microdilution methods on gram-negative (Escherichia coli, Pseudomonas aeruginosa, Proteus mirabilis), gram-positive (Staphylococcus aureus, Streptococcus salivarius) bacteria and yeast (Candida albicans). The biocidal effect of composites on biofilm formation on the surface of composites was monitored by Christensen method and autoaggregation and motility tests. The biocompatibility of the composite and the leachates was assessed by 3-(4,5-Dimethylthiazol-2-yl)-2,5-Diphenyltetrazolium Bromide (MTT) cytotoxicity assay. The evaluation of the antimicrobial effect of the leachates demonstrated that leachates of PLA composite filled with graphene oxide and Ag+ showed a stronger antimicrobial effect than leachates of PLA composite filled with vermiculite and Ag+ and Ag nanoparticles. The leachates of PLA composites containing vermiculite with HDP and HDTMA cations had a higher antimicrobial effect on G+ bacteria and yeast than G– bacteria. Bacterial growth, biofilm formation, autoaggregation and motility of the tested bacteria were most inhibited by the composite with vermiculite and Ag+ and Ag nanoparticles. Even after a 6-month degradation of this composite, bacterial growth and biofilm formation continued to be strongly inhibited up to 42 and 91%, respectively. The cytotoxic effect was proved only in the leachate of the composite with vermiculite containing HDP after 6 months of its degradation. Tests evaluating the biocompatibility of materials have shown that the vermiculite is the most preferred carrier and can be used in the future to bind other compounds. The study confirmed that PLA composite filled with vermiculite and Ag+ and Ag nanoparticles was the most stable and effective composite with the best biocompatible and biocidal properties.

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Antibacterial Character of Cationic Polymers Attached to Carbon-Based Nanomaterials

Cited by 21 publications

References 50 publications

Catechol-Based Antimicrobial Polymers

Catechol-Based Antimicrobial Polymers

Novel Pt-Ag3PO4/CdS/Chitosan Nanocomposite with Enhanced Photocatalytic and Biological Activities

Biocompatibility and biocidal effects of modified polylactide composites

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