Antibacterial Colorants: Characterization of Prodiginines and Their Applications on Textile Materials

Alihosseini, Farzaneh; Ju, Kou San; Langó, József; Hammock, Bruce D.; Sun, Gang

doi:10.1021/bp070481r

Cited by 166 publications

(136 citation statements)

References 15 publications

(16 reference statements)

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“…This compound has shown significant biological potential due to its antimicrobial (3), antimalarial (4), anticancer (24), and immunosuppressive (14) activities. According to a recent report, prodigiosin or its analogues have been considered effective biological control agents against harmful algae (17,25), have been considered cell growth regulators (13), and can be used as a natural dye (1). On the other hand, it has been known that cycloprodigiosin (cPDG) is produced only as a minor compound by a few marine bacteria, including Pseudoalteromonas (Alteromonas) rubra, Pseudoalteromonas denitrificans, and Vibrio gazogenes (1,2,10,19).…”

mentioning

confidence: 99%

Exceptional Production of both Prodigiosin and Cycloprodigiosin as Major Metabolic Constituents by a Novel Marine Bacterium, Zooshikella rubidus S1-1

Lee

Kim

Park

et al. 2011

Appl Environ Microbiol

119

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A Gram-negative, red-pigment-producing marine bacterial strain, designated S1-1, was isolated from the tidal flat sediment of the Yellow Sea, Korea. On the basis of phenotypic, phylogenetic, and genetic data, strain S1-1 (KCTC 11448BP) represented a new species of the genus Zooshikella. Thus, we propose the name Zooshikella rubidus sp. nov. Liquid chromatography and mass spectrometry of the red pigments produced by strain S1-1 revealed that the major metabolic compounds were prodigiosin and cycloprodigiosin. In addition, this organism produced six minor prodigiosin analogues, including two new structures that were previously unknown. To our knowledge, this is the first description of a microorganism that simultaneously produces prodigiosin and cycloprodigiosin as two major metabolites. Both prodigiosin and cycloprodigiosin showed antimicrobial activity against several microbial species. These bacteria were approximately 1.5-fold more sensitive to cycloprodigiosin than to prodigiosin. The metabolites also showed anticancer activity against human melanoma cells, which showed significantly more sensitivity to prodigiosin than to cycloprodigiosin. The secondary metabolite profiles of strain S1-1 and two reference bacterial strains were compared by liquid chromatography-mass spectrometry. Multivariate statistical analyses based on secondary metabolite profiles by liquid chromatography-mass spectrometry indicated that the metabolite profile of strain S1-1 could clearly be distinguished from those of two phylogenetically related, prodigiosin-producing bacterial strains.

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confidence: 99%

Exceptional Production of both Prodigiosin and Cycloprodigiosin as Major Metabolic Constituents by a Novel Marine Bacterium, Zooshikella rubidus S1-1

Lee

Kim

Park

et al. 2011

Appl Environ Microbiol

119

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“…Kulkarni et al [3] reported the application of yellow pigment in the dyeing of fabric produced by Kocuria flava sp. HO-9041 similarly application of bright red pigment prodigiosin for dying of wool, nylon, acrylic and silk had been suggested by Alihosseini et al [4] and Ahmed et al [5]. While Alcantara et al [6] have demonstrated the application of zeaxanthin from Flavobacterium sp in food as an additive in poultry feeds.…”

Section: Introductionmentioning

confidence: 95%

Production and Partial Characterization of Pigments Produced by Kocuria Sp Bri 36: Influence of Heavy Metals

Mulik

Kumbhar

Bhadekar

2017

Int J Pharm Pharm Sci

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Objective: To study the production of pigments by Kocuria sp. BRI 36, their characteristics and influence of heavy metals on pigments. Methods:The effects of various physical and chemical parameters on pigments production by Kocuria sp. BRI 36 were examined. Pigments were extracted and partially characterised by Thin Layer Chromatography (TLC) and Fourier Transform Infrared Spectroscopy (FTIR). The effects of heavy metals such as Pb 2+ , Cd 2+ , Ni 2+ and Cr 3+ were studied on pigment production. Antimicrobial activity and stability studies of crude pigment were also conducted.Results: Kocuria sp. BRI 36 isolated from cold oceanic region maximally produced red-orange pigment in presence of glucose (5% w/v) and protease peptone (0.2% w/v) at pH 7.5, 10±1 °C. Thin layer chromatography (TLC) analysis revealed the occurrence of three different compounds in the crude pigment belonging to carotenoid and xanthophyll group. Metals like Ni 2+ and Cr 3+ adversely affected pigment production while Pb 2+ and Cd 2+ enhanced the yield. The significant features of Kocuria sp. BRI 36 pigment are i) antimicrobial activity against Gram-positive and Gram-negative bacteria, ii) maximum stability at pH 7.5 and 10±1 °C and iii) ~38% color loss at 50±1 °C in 5 h. Conclusion:Our results suggest application potential of Kocuria sp. BRI 36 pigments in various biotechnological fields.

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“…Recently prodiginines have again been attracting attention because they show a variety of bioactivities, antibiotic, anticancer, antimalarial, antiprotozoal, antifungal, immune-suppressive activities and so on. [13][14][15][16][17] The MIC of streptorubin B with MRSA N315 was more than or equal to 32 µg/mL, thus anti-MRSA activity is not strong. The biofilm formation of MRSA N315 was reduced to 27% at 1 µg/mL of streptorubin B. Biofilm formation was reduced to less than 50% even in the presence of 0.17 µg/mL, less than or equal to the 1/188 of the MIC.…”

Section: )mentioning

confidence: 99%

“…In a recent study, the application of prodiginines to textile materials such as wool, nylon and acrylic has been demonstrated. 14) We believe that there are more possibilities to prevent infections by utilizing these kinds of anti-infectious compounds.…”

Section: )mentioning

confidence: 99%

A Compound Inhibits Biofilm Formation of <i>Staphylococcus aureus</i> from <i>Streptomyces</i>

Suzuki

Ohtaguro

Yoshida

et al. 2015

Biological & Pharmaceutical Bulletin

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Biofilm is one virulence factor of bacteria. It contributes not only to bacterial adherence to many kinds of infection-establishing surfaces, but also to bacterial resistance against antimicrobial agents and antiseptic agents. Thus, inhibitors of bacterial biofilm formation should be useful in the prevention of infections. We found that a culture of Streptomyces sp. strain MC11024 showed inhibitory activity on biofilm formation by Staphylococcus aureus and isolated streptorubin B as an inhibitor of this formation in S. aureus. The biofilm formation of methicillin resistant S. aureus (MRSA) N315 was reduced to less than 30% at 1 µg/mL of streptorubin B, and at this concentration cell growth was not affected. Our study suggests that streptorubin B has the potential to be a leading compound of anti-infectious agents of S. aureus. Key words biofilm; inhibitor; Staphylococcus aureus; Streptomyces; prodigiosinPathogenic bacteria produce many kinds of virulence factors and cause human infectious diseases. Among them, adherence factors are important for establishing infections. 1,2)Such factors also confer adhering and staying on every surface including medical devices. One of such factors, biofilm, is a relatively flexible and sticky structure.3) Once bacteria form biofilm on the surface of medical devices set in the human body, it is difficult to remove the biofilm. It is also known that biofilm prevents the penetration of antibacterial drugs and helps bacteria escape from host immune systems. 4)Some infections correlate with biofilm formation at the clinical site. 5)Biofilm formation by bacteria starts with the production of adhering factors. Bacterial cells attach to many kinds of surfaces via electrical charge and specific interactions. After that, bacteria develop biofilm by producing high viscosity extracellular matrix including polysaccharides, proteins, DNA and so on. After the biofilm has been developed, part of the bacteria in the biofilm releases some proteases, detaching them from the biofilm, and the small block of biofilm containing bacteria moves to other places. 6) While bacteria attach to surfaces and mature biofilm, they also release many virulence factors. 7)

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Antibacterial Colorants: Characterization of Prodiginines and Their Applications on Textile Materials

Cited by 166 publications

References 15 publications

Exceptional Production of both Prodigiosin and Cycloprodigiosin as Major Metabolic Constituents by a Novel Marine Bacterium, Zooshikella rubidus S1-1

Exceptional Production of both Prodigiosin and Cycloprodigiosin as Major Metabolic Constituents by a Novel Marine Bacterium, Zooshikella rubidus S1-1

Production and Partial Characterization of Pigments Produced by Kocuria Sp Bri 36: Influence of Heavy Metals

A Compound Inhibits Biofilm Formation of <i>Staphylococcus aureus</i> from <i>Streptomyces</i>

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