Antibacterial compounds in different species of Datura: A review

Abstract

The growing phenomenon of antibiotic resistance to pathogenic microorganisms has led to the concern of scientists on finding novel antimicrobial agents from natural sources. Datura species is a medicinal plant that has significant antibacterial properties and has been widely used to treat various diseases such as diabetes, leucoderma, skin disorders, ulcers, bronchitis, jaundice, hysteria, insanity, heart disease, fever, piles, etc. In this review, we focused on the antibacterial characteristics of plant with special reference to phytocompounds studied by various scientists in different species of Datura. Studies showed that maximum antibacterial work has been done on Datura metal, Datura inoxia and Datura stramonium against Escherichia coli, Staphylococcus aureus and Pseudomonas aeruginosa. Leaves were found to be most promising part as a source for antibacterial activities. Steroidal (5¹, 7¹ dimethyl 6¹-hydroxyl 3¹, phenyl 3 α-amine β-yne sitosterol) and β-carboline(1,7 dihydroxy-1-methyl 6,8dimethoxy β-carboline) alkaloids are the two antibacterial compounds isolated from D. metel. Research showed that the Datura species are very promising plants for isolation of new antibacterial compounds.

Bioactive prodigiosin-impregnated cellulose matrix for the removal of pathogenic bacteria from aqueous solution

“…15,16 Prodigiosin could impart an instantaneous antibacterial effect and prevent the formation of bacterial biolms. 17 Prodigiosin acts as an antibacterial agent due to its strong affinity towards DNA and its subsequent inactivation of bacterial cells. 18 Prodigiosin is efficient in the disinfection of waterborne pathogens such as fungi, algae, mosquito larvae and plankton, besides bacteria.…”

Nutrient conditions influence allelopathic capabilities of Ludwigia adscendens and other tropical macrophytes against Microcystis aeruginosa

“…In bioactive fractions, we detected the indole alkaloid pseudostrychnine and several β‐carboline alkaloids (i.e., picrasidine O and crenatidine), compounds that may possess antimicrobial activities including membrane disruption, inhibiting protein synthesis, and impeding DNA function. (e.g., Alamri & Mohamed, 2013; Cao et al., 2007; Kodani et al., 2002; Song et al., 2014; Tandon et al., 2014). Terpenoids and coumarins were the main components in less bioactive fractions and are thus expected to be less effective allelochemicals, especially compared to phenolics and alkaloids (Tamokou et al., 2017).…”

Anti-bacterial, Anti-oxidant and other Phytochemical Properties of Datura innoxia leaves

“…innoxia is a medicinal herb as it is used to treat psychosis, fevers with catarrh, diarrhea, infestations, lumps, lesions, bronchitis, asthma, pulmonary difficulties, impotency, malaria, hair loss and cutaneous infections (17 -19). Atropine, scopolamine, hyoscyamine, withanolides (lactones) and tropanes are the active factors in D. innoxia (20)(21)(22). Mostly they are explored as anti-inflammatory and anti-cancerous (23)(24)(25).…”