Antibacterial effect and mechanism of anthocyanin rich Chinese wild blueberry extract on various foodborne pathogens

Sun, Xiaohong; Zhou, Tongtong; Wei, Cai-hong; Lan, Weiqing; Zhao, Yong; Pan, Yingjie; Wu, Vivian C.H.

doi:10.1016/j.foodcont.2018.07.012

Cited by 184 publications

(123 citation statements)

References 32 publications

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“…Viable cells can generate a type of H + by utilizing the electron transfer system in TCA cycle. Generated H + converts iodonitrotetrazolium chloride to a pink color similar to that of formazan (Sun et al, ). MIC was defined as the lowest concentration at which the yellow color was unchanged.…”

Section: Resultsmentioning

confidence: 99%

“…Leakage of nucleic acids and intracellular materials can inhibit DNA synthesis and decrease adenosine 5′‐triphosphate (ATP) concentration within cells. Given this, intracellular nucleic acids and other intracellular components can be used as indicators of membrane integrity and bacterial cell damage (Nakajima et al, ; Sun et al, ). NPN is a hydrophobic fluorescence probe that shows strong fluorescence in hydrophobic conditions.…”

Section: Discussionmentioning

confidence: 99%

“…Consequently, the effects of clinical antibiotics must be estimated by evaluating their effects in the context of virulence factor secretion and growth inhibition. Sun et al, 2018). NPN is a hydrophobic fluorescence probe that shows strong fluorescence in hydrophobic conditions.…”

Section: Discussionmentioning

confidence: 99%

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Inhibitory effects of Inula britannica extract fermented by Lactobacillus plantarum KCCM 11613P on coagulase activity and growth of Staphylococcus aureus including methicillin‐resistant strains

Bae

Kim

et al. 2019

J Food Biochem

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The aim of this study was to evaluate the antimicrobial efficacy of fermented Inula britannica extract (FIBE) against Staphylococcus aureus strains including methicillin‐resistant S. aureus (MRSA). I. britannica extract was fermented by Lactobacillus plantarum KCCM 11613P, and the pathogenicity of S. aureus strains was determined via assessment of coagulase, DNase, and hemolytic activities. Epicatechin concentration increased from 4.38 to 6.05 μg/mg during fermentation (p < 0.01). FIBE treatment inhibited coagulase release from S. aureus to levels below the inhibitory concentration. FIBE promoted the release of intracellular nucleic acids and N‐phenyl‐1‐naphthylamine absorption. In three S. aureus strains, damaged cells exhibited 21.58, 16.79, and 17.65% decreases in membrane potential induced by cell membrane depolarization, respectively (p < 0.05). Upon FIBE treatment in culture, the minimum inhibitory concentration of FIBE exerted a bacteriostatic effect. In conclusion, FIBE possesses antimicrobial properties, including inhibition of virulence factors, damage to cell membranes, and inhibition of bacterial growth. Practical applications Methicillin‐resistant Staphylococcus aureus (MRSA) is a serious concern in hospitals because of its known antibiotic resistance. Vancomycin and tigecycline are used for treating MRSA, but the appearance of vancomycin‐intermediate and multidrug‐resistant strains of these bacteria has created a demand for new antimicrobial agents. This study demonstrates the effective application of Inula britannica and fermentation technology for developing natural antimicrobial agents against methicillin‐resistant Staphylococcus aureus.

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Section: Resultsmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

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Inhibitory effects of Inula britannica extract fermented by Lactobacillus plantarum KCCM 11613P on coagulase activity and growth of Staphylococcus aureus including methicillin‐resistant strains

Bae

Kim

et al. 2019

J Food Biochem

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“…Current researches have demonstrated the strong antimicrobial effects of anthocyanins, e.g., inhibiting the growth of Listeria monocytogenes, Staphylococcus aureus, Salmonella enteritidis and Vibrio parahaemolyticus [5]. In addition, anthocyanins can lower blood glucose levels by protecting b-cells, improving insulin resistance, increasing insulin secretion, improving liver function and inhibiting carbohydrate hydrolyzing enzymes [6].…”

Section: Introductionmentioning

confidence: 99%

Preparation and pH Controlled Release of Fe3O4/Anthocyanin Magnetic Biocomposites

et al. 2019

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Anthocyanins are a class of antioxidants extracted from plants, with a variety of biochemical and pharmacological properties. However, the wide and effective applications of anthocyanins have been limited by their relatively low stability and bioavailability. In order to expand the application of anthocyanins, Fe 3 O 4 /anthocyanin magnetic biocomposite was fabricated for the storage and release of anthocyanin in this work. The magnetic biocomposite of Fe 3 O 4 magnetic nanoparticle-loaded anthocyanin was prepared through physical intermolecular adsorption or covalent cross-linking. Scanning electron microscopy (SEM), Dynamic light scattering (DLS), Fourier-transform infrared spectroscopy (FTIR), X-ray diffractometry (XRD) and thermal analysis were used to characterize the biocomposite. In addition, the anthocyanin releasing experiments were performed. The optimized condition for the Fe 3 O 4 /anthocyanin magnetic biocomposite preparation was determined to be at 60 • C for 20 h in weak alkaline solution. The smooth surface of biocomposite from SEM suggested that anthocyanin was coated on the surface of the Fe 3 O 4 particles successfully. The average size of the Fe 3 O 4 /anthocyanin magnetic biocomposite was about 222 nm. Under acidic conditions, the magnetic biocomposite solids could be repeatable released anthocyanin, with the same chemical structure as the anthocyanin before compounding. Therefore, anthocyanin can be effectively adsorbed and released by this magnetic biocomposite. Overall, this work shows that Fe 3 O 4 /anthocyanin magnetic biocomposite has great potential for future applications as a drug storage and delivery nanoplatform that is adaptable to medical, food and sensing.

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“…The color affects fruit quality, and the formation of fruit pigments depends on anthocyanin synthesis during fruit growth and development. Moreover, in plants, accumulated anthocyanins enhance resistance to biotic and abiotic stresses, such as UV-B light damage [2], pathogen infection [3], wounding [4], and drought [5].…”

Section: Introductionmentioning

confidence: 99%

Jasmonate and Ethylene-Regulated Ethylene Response Factor 22 Promotes Lanolin-Induced Anthocyanin Biosynthesis in ‘Zaosu’ Pear (Pyrus bretschneideri Rehd.) Fruit

Liu

Zhao

et al. 2020

Biomolecules

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Anthocyanin contributes to the coloration of pear fruit and enhances plant defenses. Members of the ethylene response factor (ERF) family play vital roles in hormone and stress signaling and are involved in anthocyanin biosynthesis. Here, PbERF22 was identified from the lanolin-induced red fruit of 'Zaosu' pear (Pyrus bretschneideri Rehd.) using a comparative transcriptome analysis. Its expression level was up-and down-regulated by methyl jasmonate and 1-methylcyclopropene plus lanolin treatments, respectively, which indicated that PbERF22 responded to the jasmonateand ethylene-signaling pathways. In addition, transiently overexpressed PbERF22 induced anthocyanin biosynthesis in 'Zaosu' fruit, and a quantitative PCR analysis further confirmed that PbERF22 facilitated the expression of anthocyanin biosynthetic structural and regulatory genes. Moreover, a dual luciferase assay showed that PbERF22 enhanced the activation effects of PbMYB10 and PbMYB10b on the PbUFGT promoter. Therefore, PbERF22 responses to jasmonate and ethylene signals and regulates anthocyanin biosynthesis. This provides a new perspective on the correlation between jasmonate-ethylene crosstalk and anthocyanin biosynthesis.

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Antibacterial effect and mechanism of anthocyanin rich Chinese wild blueberry extract on various foodborne pathogens

Cited by 184 publications

References 32 publications

Inhibitory effects of Inula britannica extract fermented by Lactobacillus plantarum KCCM 11613P on coagulase activity and growth of Staphylococcus aureus including methicillin‐resistant strains

Inhibitory effects of Inula britannica extract fermented by Lactobacillus plantarum KCCM 11613P on coagulase activity and growth of Staphylococcus aureus including methicillin‐resistant strains

Preparation and pH Controlled Release of Fe3O4/Anthocyanin Magnetic Biocomposites

Jasmonate and Ethylene-Regulated Ethylene Response Factor 22 Promotes Lanolin-Induced Anthocyanin Biosynthesis in ‘Zaosu’ Pear (Pyrus bretschneideri Rehd.) Fruit

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