Antibacterial effect of a non-specific immunomodulator based on muramilpeptides in chronic periodontitis

Grudyanov, A.I.; Fomenko, E.V.; Kalyuzhin, O. V.

doi:10.17116/stomat202110004116

Cited by 3 publications

(1 citation statement)

References 5 publications

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“…The most pronounced immunomodulatory effect is provided by muramyldipeptide (MDP), a minimal bacterial wall peptidoglycan component (Grudyanov et al, 2021). Preparations based on it belong to the immunomodulator's third generation.…”

Section: Introductionmentioning

confidence: 99%

Features of the functioning of the natural defense mechanisms of piglets under the influence of immunotropic substances

Masiuk,

Nedzvetsky,

Kokariev

2023

SMLNUVMB

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The number of studies related to detailed characteristics of immune system development in early stages of ontogenesis are directed to expansion of concepts of mechanisms of inherent and adaptive immunity in premature newborns. However, discrepancy in publication data and absence of clear conceptions about unique features of immune system in newborn piglets for different gestation periods have significant actuality for further investigation. The study was carried out to establish characteristics of phenotypic and functional characteristics of the immune cells and establishment of adaptive immunity in piglets. The antibody repertoire of sow has interested immunologists for decades, in part because of the ease with which large quantities of high affinity antibodies can be observed in serum, and into other fluids because of the presence of genetic variants for both light and heavy chain of all known immunoglobulin types. The integrative analysis of the cellular and humoral immunity in piglets during early ontogenesis carried out to clarify the exact mechanisms of the immune response modulation. Effectiveness and selectivity of the immunotropic chemicals application to regulate immune cell populations in piglets is presented. The progress in immune cell populations is regulated by the various cytokines production in the universal concentration-dependent manner. Furthermore, the development of the immune functions cross reacts with innate immunity mechanisms including anti-bacterial enzymes, epithelial barrier integrity in the both skin and intestine. The interaction between multiple components of innate immunity is a critic initiator of the dynamic changes in adaptive immunity. The natural resistance targets to the establishment of infection root and delays disease progression. The duration of the exposure to colostrum in important role in the dynamics of immune response as well as its efficacy. The chapter discusses the plural mechanisms so far proposed to be responsible for the modulation natural resistance.

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Section: Introductionmentioning

confidence: 99%

Features of the functioning of the natural defense mechanisms of piglets under the influence of immunotropic substances

Masiuk,

Nedzvetsky,

Kokariev

2023

SMLNUVMB

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The assessment of a role of muramyl peptides in the treatment of patients with aggressive form of periodontitis

Grudyanov¹,

Fomenko²,

Bystritskaya³

et al. 2022

Stomat.

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Dynamics of Cytokine Profile Indicators in Experimental Periodontitis

Захватов

Khaydar

T.V.

et al. 2022

Vestnik "Biomedicina i sociologiya"

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Abstract. The molecular level of physiological processes in the context of studying the pathogenesis of diseases is the basis for their diagnosis and treatment. Thus, the features of the pathogenesis of periodontitis are the direct participation of pro-inflammatory cytokines in the development of alterative inflammation. The study of the cytokine profile is relevant for both diagnostic and therapeutic purposes, since the dynamics of indicators of inflammatory mediators reflects the degree of activity and specificity of pathological reactions present in periodontitis. The purpose of the study Study of cytokine profile indicators in experimental periodontitis. Materials and methods. In an experiment on 50 white non-linear rats weighing 190-280 g, the model of experimental periodontitis proposed by Shkolnaya K.D., Atrushkevich V.G. was reproduced. (Patent RU No. 2625295 dated 07/12/2017). Assessment of the dynamics of the cytokine status of blood serum was carried out by the level of pro-inflammatory (IL-1β, TNF, IL-6, IL-17), anti-inflammatory (IL-4, IL-10) and regulatory (IL-2) cytokines using enzyme-linked immunosorbent assay using reagent kit "Bender MedSystems". Results. The study revealed the presence of an imbalance in the cytokine system, characterized by a violation of the physiological balance between pro-inflammatory and anti-inflammatory cytokines with a predominance of the former. Hyperproduction of cytokines persisted throughout the experiment with an increase in the above uncoupling by day 25, which indicates the formation of an immunoinflammatory process in the periodontium. Conclusion. The data obtained during the study confirm the presence of an imbalance of the cytokine network, which indicates the formation and progression of the inflammatory process of the periodontal complex, and also necessitates the introduction of drugs that inhibit the synthesis of pro-inflammatory mediators into complex therapy.

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Antibacterial effect of a non-specific immunomodulator based on muramilpeptides in chronic periodontitis

Cited by 3 publications

References 5 publications

Features of the functioning of the natural defense mechanisms of piglets under the influence of immunotropic substances

Features of the functioning of the natural defense mechanisms of piglets under the influence of immunotropic substances

The assessment of a role of muramyl peptides in the treatment of patients with aggressive form of periodontitis

Dynamics of Cytokine Profile Indicators in Experimental Periodontitis

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