Antibacterial effect of fucoidan from Sargassum wightii against the chosen human bacterial pathogens

Abstract

The present study was aimed to evaluate the antibacterial capability of fucoidan from Sargassum wightii against the chosen human bacterial pathogens. The major chemical constituents of the extracted fucoidan were analyzed by biochemical methods. It showed that the extracted fucoidan contains 52.86 ± 0.64% of fucose and 29.26 ± 0.83% of sulphate. The antibacterial efficacy was performed by agar well diffusion, minimum inhibitory concentration (MIC) and minimum inhibitory concentration (MBC) method. The maximum antibacterial activity 18.6 ± 0.32 mm was obtained for Vibrio cholera and the minimum activity 8.6 ± 0.26 mm was obtained for Salmonella typhi. Result of this manifested the considerable antibacterial potentiality of fucoidan against human bacterial pathogens. Toxicity of fucoidan was evaluated by brine shrimp toxicity assay. No toxic effect was observed in fucoidan. Our study concluded that fucoidan might be used as natural and safe antibiotics in curing many bacterial diseases. Further study is required to get the better understanding of mode of action of fucoidan against the bacterial pathogens.DOI: http://dx.doi.org/10.3329/icpj.v2i10.16408 International Current Pharmaceutical Journal, September 2013, 2(10): 156-158

Antibacterial Potential of Aqueous Extracts and Compounds from Selected Brown Seaweeds

“…Based on the results of antibacterial susceptibility test on fucoidan and alginic acid in the present study, fucoidan (0.50 mol/L) and alginic acid (0.50 mol/L) were observed to have antibacterial property against Gram-positive bacteria S. aureus (inhibition zone of 7.43±0.17 mm and 7.45±0.14 mm, respectively). This is in agreement with the study of Marudhupandi and Kumar that showed the inhibition of fucoidan against Vibrio cholerae (18.6±0.32 mm) and Salmonella typhi (8.6±0.26 mm) [23].…”

Antimicrobial potential of macro and microalgae against pathogenic and spoilage microorganisms in food

“…Another very interesting group of polysaccharides obtained from algae with a demonstrated antimicrobial potential is Fucoidans (polysaccharides from Phaeophyta). Among the most important properties of these polysaccharides are the following: anticoagulant, antithrombotic, antiviral, antitumor, immunomodulatory, antioxidant, and anti-inflammatory (Li, Lu, Wei, & Zhao, 2008;Marudhupandi & Kumar, 2013). According to the studies of De Jesus Raposo, Bernardo de Morais, and Santos Costa de Morais (2015), sulphated polysaccharides from seaweeds (among them alginates, fucoidans and laminaran) have demonstrated to be effective against E. coli and Staphylococcus aureus (Chaetomorpha aerea, 50 mg/mL of extract).…”

Inhibitory Effect of Depolymerized Sulfated Galactans from Marine Red Algae on the Growth and Adhesion of Diarrheagenic Escherichia coli

“…As the main bioactive components in marine algae, sulfated polysaccharides, particularly their bacteriostatic or bactericidal activity, have attracted attention [4]. In brown algae, the sulfated polysaccharides from Laminaria japonica and Sargassum swartzii can inhibit Gram-negative and -positive bacteria including E. coli, Vibrio cholera, Salmonella typhi, and Staphylococcus aureus [5,6]. The sulfated polysaccharides from green algae (Chaetomorpha aerea) and microalgae (Porphyridium cruentum) also display inhibitory effect on S. aureus and Salmonella enteritidis, respectively [7,8].…”