Antibacterial effect of Phellinus linteus against methicillin-resistant Staphylococcus aureus

Styrylpyrone-class compounds from medicinal fungi Phellinus and Inonotus spp., and their medicinal importance

“…Nevertheless, the cultivated mushroom or cultured mycelia of P. linteus exhibited biological activities comparable to the wild-grown mushroom, and produced an abundant amount of yellow pigments containing mainly styrylpyrones with various biological activities. 28,29,34,[52][53][54][55][56][57]60,64,[72][73][74][75] In addition, the adverse effects of the medicinal mushrooms Phellinus and Inonotus have not been reported until now. Methanolic extracts of I. xeranticus did not show acute toxicity up to 2 g kg À1 in mice, and the LD 50 values of these extracts were above 2 g kg À1 , indicating the safe nature of these mushrooms.…”

Antibacterial Agents from Lignicolous Macrofungi

“…Lignicolous macrofungi express significant biological effects, including antibacterial activity (Hur et al, 2004;Ishikawa et al, 2005;Kalyoncu et al, 2010) and their secondary metabolites can be easily extracted and identified. It has been found that secondary metabolites are very divergent in structure and play no essential role in their growth and reproduction, but probably have a function in biochemical evolution of a species ensuring its survival (Engler et al, 1998).…”

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“…The antimicrobial effect of the ethanolic extract of Laetiporus sulphureus was tested by Turkoglu et al [48] and strongly inhibited the growth of the gram-positive [11]. This mushroom (aqueous extract) as well as the n-BuOH fraction of the Phellinus linteus methanol extract demonstrated good activity against MRSA [50,51]. Furthermore, Streptococcus pyogenes was very sensitive to the Lentinus edodes chloroform extract [52].…”

“…The ether extract of Pleurotus sajor-caju showed high antibacterial activity against Staphylococcus aureus, whereas Staphylococcus epidermidis showed high sensitivity for the ethanol extract [33]. Overall, it should be pointed out that the most susceptible grampositive bacteria to mushroom inhibitory action are MRSE -methicillin-resistant Staphylococcus epidermidis; PRSP -penicillin-resistant Streptococcus pneumonia; ERSP -erythromycin-resistant Streptococcus pyogenes microorganism was also inhibited by Phellinus linteus [51] and Pleurotus ostreatus [50]. It is important to develop new studies with different mushroom species and, moreover, with these microorganisms that are so problematic to human health.…”