Antibacterial Effect of the Kampo Herbal Medicine, Hochu-ekki-to on Methicillin-Resistant Staphylococcus aureus Positive Mice.

Matsui, Kenichiro; Uechi, Yoko; Horiguchi, Akiko; Gao, Yang; Kitada, Yoshihiko; Ono, Yutaka; Ogata, Yuko; Wang, Xiuxia; Li, Nong; Komatsu, Yasuhiro; Shimizu, Shōji; Yamaguchi, Nobuo

doi:10.3937/kampomed.48.357

Cited by 3 publications

(5 citation statements)

References 6 publications

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“…The mechanisms of the potent inhibitory effect of this formulation on tumour growth are mainly explained by its enhancement of natural killer cell activity 59 and by the restoration of the anti-tumour T-cell response. 60,61 On the other hand, Hochuekkito improved the acquired immunodeficiency induced by mitomycin C in mice 62 and reduced the occurrence of infections with methicillin-resistant Staphylococcus aureus (MRSA), 63 Candida albicans, 64 Salmonella enteritidis , 65 herpes simplex virus type-1 (HSV-1) 66 and influenza virus 67 in mice. From these reports Hochuekkito seems to be useful for the reinforcement of physical strength after disease or surgery.…”

Section: Hochuekkitomentioning

confidence: 99%

Pharmacology and Toxicology of Bupleurum Root-Containing Kampo Medicines in Clinical Use

et al. 2006

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Kampo (Japanese traditional herbal) medicines have been produced by combining multiple crude drugs, almost all of plant origin but with some of animal or mineral origin, and contain a great many substances. Their effect is a combination of the various interactions of the constituent substances, whether they are enhancing, synergistic or suppressive. Kampo medicine has an overall effect that is different from the combined effects of individual crude drugs, and several side effects such as anorexia, slight fever and nausea have been reported in the treatment of certain disorders and disease states with Kampo medicines. Among 210 medical formulations used in Japan, some relevant information on the clinical uses, pharmacology and toxicology of six manufactured Kampo medical formulations, Shosaikoto, Daisaikoto, Saikokeishito, Hochuekkito, Saibokuto and Saireito, containing Bupleurum root are reviewed. Studies of some potential interactions between Kampo medicine and western drugs are also considered.

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Section: Hochuekkitomentioning

confidence: 99%

Pharmacology and Toxicology of Bupleurum Root-Containing Kampo Medicines in Clinical Use

et al. 2006

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“…Kampo medicines generally consist of several crude drugs and include various bioactive compounds including flavonoids, alkaloids, triterpenoid saponins, and lactones. Certain Kampo medicines have been shown to promote intestinal immunity and protect against bacterial infections 10 – 12 . Regarding methicillin-resistant Staphylococcus aureus (MRSA), Nishida reported that hochuekkito (HET), a Kampo medicine formulation composed of 10 types of crude drugs and used to treat disease and stimulate immune function, significantly reduced the urine bacterial count 10 weeks after administration 10 .…”

Section: Introductionmentioning

confidence: 99%

“…Regarding methicillin-resistant Staphylococcus aureus (MRSA), Nishida reported that hochuekkito (HET), a Kampo medicine formulation composed of 10 types of crude drugs and used to treat disease and stimulate immune function, significantly reduced the urine bacterial count 10 weeks after administration 10 . Matsui et al 12 reported that HET could inhibit MRSA growth and extend the survival time of MRSA-infected mice. Nakae et al reported that juzentaihoto (JTT) led to negative bacterial cultures in five cases of refractory multidrug-resistant bacterial infection, including a MRSA case with severe burns 13 .…”

Section: Introductionmentioning

confidence: 99%

A Japanese traditional medicine Hochuekkito promotes negative conversion of vancomycin-resistant Enterococci

Kohno

Kawamura

Kikuchi

et al. 2021

Sci Rep

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Vancomycin-resistant enterococci (VRE) are prominent causes of nosocomial infections. Japanese traditional (Kampo) medicine promotes intestinal immunity and protects against bacterial infections. We assessed potential differences in the clinical course of VRE-positive patients, based on their characteristics and treatment with Kampo medicines. This retrospective observational study collected data from VRE-positive patients from August 2018 to July 2019 at a tertiary-care hospital in Japan. The data of 122 consecutive VRE-positive inpatients were analyzed. Sixty-nine patients were treated with probiotics, among whom, 18 were further treated with Kampo medicines. Twenty-six of the 122 patients subsequently died. In univariate analyses, subsequent VRE negative conversion significantly reduced the mortality of VRE-detected patients (p = .0003). Administration of probiotics (p = .0065) and Kampo medicines with probiotics (p = .0002), especially of the Kampo medicine hochuekkito (p = .0014), and a higher serum albumin level positively contributed to the subsequent VRE negative conversion. Multivariate analyses demonstrated that Kampo medicines and body mass index contributed to VRE negative conversion. Hochuekkito shortened the time needed for VRE negative conversion (p = 0.0485). Administration of Kampo medicines, especially of hochuekkito, in addition to probiotics in VRE patients may promote VRE negative conversion.

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“…For in vivo experiments, HET extract was orally administered by gavage at a dose of 1,000 mg/kg/day. This dosage was determined based on the results of the previous studies (1,2,12,16,20,25,30).…”

Section: Methodsmentioning

confidence: 99%

“…There have been some reports that HET activates murine macrophage functions such as phagocytosis in vitro and cytokine production (15), and enhances bactericidal activity by augmenting natural killer (NK) activity (20,25). The results of the present study showed that the colonization of H. pylori was more strongly inhibited in the mice treated with HET before infection than in the mice treated with HET after infection, suggesting that the antibacterial effect of HET against H. pylori infection may involve the enhancement of immune responses.…”

Section: H Pylori Infection and Hochu-ekki-tomentioning

confidence: 99%

Antibacterial Effect of Kampo Herbal Formulation Hochu‐Ekki‐To (Bu‐Zhong‐Yi‐Qi‐Tang) on Helicobacter pylori Infection in Mice

Yan

Kita

Minami

et al. 2002

Microbiology and Immunology

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Because Helicobacter pylori (H. pylori) infection is a major cause of gastroduodenal diseases in humans, the eradication of H. pylori using antibiotics is very effective for the treatment of gastroduodenal diseases. However, it has recently been reported that resistance to these antibiotics is developing. In the present study, the antibacterial effect of a Kampo (traditional Japanese medicine) herbal formulation, Hochu‐ekki‐to (HET; Formula repletionis animalis et supletionis medii), against H. pylori was examined in vitro and in vivo. HET inhibited the growth of antibiotic‐resistant strains of H. pylori as well as antibiotic‐sensitive strains at a dose of 2.5 mg/ml in vitro. When 1,000 mg/kg of HET was administered orally to C57BL/6 mice for 7 days before or after inoculation with H. pylori, H. pylori in the stomach was significantly reduced in the HET‐pre‐treatment group compared with the control group. Furthermore, HET in combination with antibiotics completely eradicated the bacteria in mice. The expression of interferon (IFN)‐γ was induced in the gastric mucosa of the mice pre‐treated with HET. There were no significant differences between the colonization of H. pylori in the control and HET treatment groups in IFN‐γ gene‐deficient mice. These results suggest that the antibacterial effect of HET may be partly due to IFN‐γ induction, and that HET may be clinically useful for treatment of H. pylori infection.

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Antibacterial Effect of the Kampo Herbal Medicine, Hochu-ekki-to on Methicillin-Resistant Staphylococcus aureus Positive Mice.

Cited by 3 publications

References 6 publications

Pharmacology and Toxicology of Bupleurum Root-Containing Kampo Medicines in Clinical Use

Pharmacology and Toxicology of Bupleurum Root-Containing Kampo Medicines in Clinical Use

A Japanese traditional medicine Hochuekkito promotes negative conversion of vancomycin-resistant Enterococci

Antibacterial Effect of Kampo Herbal Formulation Hochu‐Ekki‐To (Bu‐Zhong‐Yi‐Qi‐Tang) on Helicobacter pylori Infection in Mice

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