Antibacterial Effect of Zinc Oxide Nanoparticles on Mupirocin-Resistant Staphylococcus aureus Isolated From Nasal Carriers

Hajimohammad, Afsaneh; Fozouni, Leila

doi:10.15171/ijbsm.2018.14

Cited by 6 publications

(4 citation statements)

References 22 publications

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“…Previous investigations have similarly established nanoparticles of smaller dimensions (> 100 nm) exhibit superior antimicrobial properties. In the current investigation, the utilization of AuNPs with a size of 30 nm exhibited noteworthy antibacterial activity, surpassing that observed in prior studies [29][30][31]. Grace et al (2007) demonstrated the efficacy of AuNPs against Grampositive and Gram-negative bacteria [32].…”

Section: Fig 1 Comparison Of Mean Absorbance At 570 Nm In Drug-resist...contrasting

confidence: 55%

The Impact of Gold Nanoparticle Susceptibility on Drug Resistance Phenotypes in Uropathogenic Escherichia coli

Hosseinpour,

Fozouni,

Khademi

et al. 2023

JoMMID

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Introduction:The widespread use of antibiotics has contributed to the dissemination of multidrug-resistant pathogens. This study aimed to assess the prevalence of Escherichia coli strains associated with urinary tract infections, characterized by diverse drug-resistance phenotypes. Additionally, the antibacterial properties of gold nanoparticles were examined against each phenotype to determine their effectiveness. Methods: This cross-sectional study was conducted on 170 E. coli strains isolated from 250 urine samples collected from symptomatic and asymptomatic patients with urinary tract infections (UTIs) between August 2022 and July 2023. The antibiotic susceptibility profiles across various classes of antibiotics were determined using the Kirby-Bauer method. At the same time, the minimum inhibitory concentrations of gold nanoparticles were assessed through the microdilution broth test. Results: Among E. coli isolates, 91 (53.53%), 45 (26.47%), and 17 (10%) isolates were identified as multidrug-resistant (MDR), extensively drug-resistant (XDR), and pandrugresistant (PDR), respectively. The MIC of gold nanoparticles that inhibited the growth of 90% of PDR isolates (MIC90=200 ppm) was two times higher than the MIC90 against XDR isolates (MIC90=100 ppm) and four times higher than the MIC90 against MDR isolates (MIC90=50 ppm). There was also a significant difference between the MIC90 and the MIC of gold nanoparticles that inhibited the growth of 50% of PDR and XDR bacteria (P<0.05). Conclusion: The emergence of MDR, XDR, and PDR uropathogenic E. coli isolates represents a significant societal health concern. Considering the favorable in vitro antimicrobial potential of gold nanoparticles against uropathogenic E. coli isolates, it is recommended to further analyze their applicability as antibiotic alternatives by conducting in vivo studies.

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Section: Fig 1 Comparison Of Mean Absorbance At 570 Nm In Drug-resist...contrasting

confidence: 55%

The Impact of Gold Nanoparticle Susceptibility on Drug Resistance Phenotypes in Uropathogenic Escherichia coli

Hosseinpour,

Fozouni,

Khademi

et al. 2023

JoMMID

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“…However, the authors in [67] reported that TiOPs had no antibacterial effect. Many authors have reported antibacterial effects of ZnONPs against several isolates, such as Staphylococcus sp., [68] methicillin-resistant Staphylococcus aureus, [69], Pseudomonas sp. [70] and Escherichia coli [71].…”

Section: Discussionmentioning

confidence: 99%

Interactive Effects of Biosynthesized Nanocomposites and Their Antimicrobial and Cytotoxic Potentials

et al. 2021

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The present study investigated the biosynthesis of silver (AgNPs), zinc oxide (ZnONPs) and titanium dioxide (TiO2NPs) nanoparticles using Aspergillusoryzae, Aspergillusterreus and Fusariumoxysporum. Nanocomposites (NCs) were successfully synthesized by mixing nanoparticles using a Sonic Vibra-Cell VC/VCX processor. A number of analytical techniques were used to characterize the synthesized biological metal nanoparticles. Several experiments tested biologically synthesized metal nanoparticles and nanocomposites against two types of human pathogenic bacteria, including Gram-positive Staphylococcus aureusand methicillin-resistant Staphylococcus aureus (MRSA), and Gram-negative Escherichia coli and Pseudomonasaeruginosa. Additionally, the antitumor activity in HCT-116 cells (colonic carcinoma) was also evaluated. Significant antimicrobial effects of various synthesized forms of nanoparticles and nanocomposites against E. coli and P. aeruginosa bacteria were detected. Various synthesized biogenic forms of nanoparticles and nanocomposite (9.0 to 29 mm in diameter) had high antibacterial activity and high antitumor activity against HCT-116 cells (colonic carcinoma) with IC50 values of 0.7–100 µg/mL. Biosynthesized NPs are considered an alternative to large-scale biosynthesized metallic nanoparticles and nanocomposites, are simple and cost effective, and provide stable nanomaterials.

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“…In the present study, 31 (18.9%) of the hospital staff were nasal carriers of S. aureus. As reported by researchers in Iran in 2010 (18) and 2018 (19), 32% and 26.8% of the hospital staff were carriers of S. aureus. It was higher than the amount found in the present study.…”

Section: Discussionmentioning

confidence: 78%

The Potency of Tedizolid, Linezolid, and Vancomycin Against Extensively Drug-Resistant Staphylococcus aureus Clinical Isolates

Fozouni

Pishdad

Kolbadinezhad

2022

Zahedan J Res Med Sci

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Background: Staphylococcus aureus is considered a normal flora by colonization in the nose and skin of humans, yet it is a major cause of nosocomial infections and a life-threatening pathogen. Among antibiotics, oxazolidinones and glycopeptides have activity against gram-positive pathogens. Objectives: The present study aimed to determine the frequency and comparison of the minimum inhibitory concentration of tedizolid, linezolid, and vancomycin against extensively drug-resistant (XDR) S. aureus strains isolated from hospitalized patients. Methods: This descriptive-analytical study was performed on 58 S. aureus isolates collected from 164 hospitalized patients over the course of one year. The Kerby-Bauer test was used to identify XDR isolates. Broth microdilution test was used according to CLSI M100-S25 (2015) criteria to determine the minimum inhibitory concentration (MIC) of vancomycin, linezolid, and tedizolid. Results: The frequency of XDR S. aureus clinical isolates was 28 (48.3%). Determining MIC showed that all XDR S. aureus isolates tested were susceptible to tedizolid (MIC, ≤ 2 μg/mL), while 92/8% (MIC, ≤ 4 μg/mL) and 60.70% (MIC, ≤ 2 μg/mL) of XDR isolates were categorized as susceptible to linezolid and vancomycin, respectively. The concentration of tedizolid that inhibited 90% of isolates (MIC90) was 2 μg/mL, 2-fold lower than linezolid (MIC90 = 4 μg/mL) and 64-fold lower than vancomycin (MIC90 = 128 μg/mL). There was a significant difference between the frequency of XDR isolates from the aspirate, trachea, and wound infections, so 22% of vancomycin-resistant isolates and all strains resistant to linezolid were isolated from hospitalized patients in the infectious ward (P = 0.04). Conclusions: We conclude that tedizolid has a beneficial effect on XDR isolates of S. aureus and possesses more potent in vitro activity than the rest agents.

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Antibacterial Effect of Zinc Oxide Nanoparticles on Mupirocin-Resistant Staphylococcus aureus Isolated From Nasal Carriers

Cited by 6 publications

References 22 publications

The Impact of Gold Nanoparticle Susceptibility on Drug Resistance Phenotypes in Uropathogenic Escherichia coli

The Impact of Gold Nanoparticle Susceptibility on Drug Resistance Phenotypes in Uropathogenic Escherichia coli

Interactive Effects of Biosynthesized Nanocomposites and Their Antimicrobial and Cytotoxic Potentials

The Potency of Tedizolid, Linezolid, and Vancomycin Against Extensively Drug-Resistant Staphylococcus aureus Clinical Isolates

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