Antibacterial Effect of Zinc Oxide in Vitro

Söderberg, Thor A.; Sunzel, Bo; Holm, Stig E.; Elmros, T; Hallmans, Göran; Sjöberg, Staffan

doi:10.3109/02844319009041278

Cited by 89 publications

(54 citation statements)

References 7 publications

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“…Indeed, the antimicrobial properties of ZnO are well known in human medical practice (Sordeberg et al 1990). Zinc oxide-based ointments are used routinely for dermal applications, and ZnO has also been shown to increase wound healing (Prasad 1983).…”

Section: Discussionmentioning

confidence: 99%

Growth-promoting efficacy of pharmacological doses of tetrabasic zinc chloride in diets for nursery pigs

Mavromichalis¹,

Webel²,

Parr³

et al. 2001

Can. J. Anim. Sci.

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. 2001. Growth-promoting efficacy of pharmacological doses of tetrabasic zinc chloride in diets for nursery pigs. Can. J. Anim. Sci. 81: 387-391. Zinc oxide (ZnO) is a reliable growth-promoting agent in young pigs when added to provide pharmacologic levels of dietary Zn. Tetrabasic zinc chloride (TBZC), whose formula is Zn 5 Cl 2 (OH) 8 , was tested in three experiments as a replacement for Waelz-processed ZnO. In exp. 1, 150 weaned pigs (5.2 kg) in five replicates received 0, 1500, or 3000 mg Zn kg -1 from either ZnO or TBZC in a 21 d growth assay in which antimicrobial agents were not contained in the diet. Both sources of supplemental Zn increased (P < 0.05) weight gain and feed efficiency, but feed efficiency was improved (P < 0.05) to a greater extent by TBZC than by ZnO, particularly at the 1500 mg Zn kg -1 dose level. In exp. 2, 144 weaned pigs (5.1 kg) in eight replicates received either 0 or 1500 mg Zn kg -1 from either ZnO or TBZC in a 19 d growth assay that included an antibacterial agent (carbadox) in all diets. Weight gain did not respond to Zn supplementation, regardless of Zn source, but feed efficiency was improved by TBZC addition to the diet. In exp. 3, 180 weaned pigs (4.5 kg) in five replicates received no supplemental Zn, 3000 mg Zn kg -1 from ZnO, or four incremental doses (750, 1500, 2250 and 3000 mg Zn kg -1 ) of TBZC in a 21 d growth assay that included carbadox in the basal diet. Supplemental Zn from ZnO at 3000 mg Zn kg -1 increased both weight gain (P < 0.05) and feed efficiency (P < 0.06). Incremental Zn additions from TBZC indicated that both weight gain and gain/feed ratio were increased (P < 0.05) and that 1500 mg Zn kg -1 from TBZC was the optimal dose for this source of Zn. The results of these experiments support the view that TBZC is a very effective source of Zn for enhancing growth performance of newly weaned pigs fed diets with or without an added antimicrobial agent.

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Section: Discussionmentioning

confidence: 99%

Growth-promoting efficacy of pharmacological doses of tetrabasic zinc chloride in diets for nursery pigs

Mavromichalis¹,

Webel²,

Parr³

et al. 2001

Can. J. Anim. Sci.

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“…A considerar a alta afinidade do óxido de zinco com Staphylococcus aureus (Soderberg et al 1990, Sawai 2003 o principal patógeno da mastite (Brito et al 2001, Taponen & Pyörälä 2009). Outro fator importante é que o uso do óxido de zinco foi consolidado na farmacêutica humana com indicações para tratamentos de afecções dermatológicas, agindo como antisséptico, secativo e adstringente, através de formulações de cremes, loções, pomadas, pasta d'água, em altas concentrações (Batistuzzo et al 2011, Anvisa 2012.…”

Section: Teste Das Soluções De óXido De Zinco E De Nitrato De Prata Cunclassified

Soluções de óxido de zinco e de nitrato de prata como alternativa para antissepsia de tetos de bovinos (teste in situ)

et al. 2017

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RESUMO: Este trabalho teve como objetivo analisar o potencial das soluções de óxido de zinco e de nitrato de prata como alternativa para antissepsia de tetos de bovinos (in situ), considerando a escassez de literatura a respeito do uso destes compostos na profilaxia de mastites. Primeiramente foram realizados ensaios de microdiluição e CBM (Concentração Bactericida Mínima) a fim de verificar a atividade antimicrobiana das soluções de óxido de zinco e de nitrato de prata sobre 30 isolados de Staphylococcus spp., obtidos de casos de mastite. Todos os isolados apresentaram sensibilidade às duas soluções testadas, mas a solução de nitrato de prata apresentou menores valores de CBMs (3,05 a 97,65 μg/mL), quando comparada as CBMs da solução de óxido de zinco (97,65 a 6.250μg/mL). Posteriormente, foram conduzidos os ensaios de antissepsia dos tetos (in situ) através da imersão dos mesmos nas soluções antimicrobianas testadas. Para isso, foram utilizados 40 tetos (n=40) oriundos de vacas abatidas, os quais foram divididos em 4 grupos de 10 tetos, destinados ao teste das solução de óxido de zinco a 3% (30mg/mL), de nitrato e prata 1% (10mg/mL) e seus respectivos controles. Os tetos foram submetidos à contagem de microrganismos mesófilos na superfície dos tetos (UFC/cm2) antes e após a imersão nas soluções testadas. Como resultado, todas as soluções (de óxido de zinco e de nitrato de prata) apresentaram significativa redução de UFC/cm2 até aos 60 minutos após a imersão (M 0’ a M 60’). A solução de nitrato de prata apresentou redução de UFC/cm2 significativamente maior, quando comparado ao grupo testado com solução de óxido de zinco. Tais resultados validam o potencial das soluções de óxido de zinco e nitrato de prata para utilização no pré e pós-dipping em vacas leiteiras.

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“…Among the metal oxide nanoparticles, the ZnO NPs have been commonly used for their antimicrobial properties. ZnO has been found to reduce the activity of wide range of bacteria [10,11]. With the use of NPs the antibacterial property increased significantly [12][13][14].…”

Section: Antibacterial Propertymentioning

confidence: 99%

Zinc Oxide Nanoparticles: Opportunities and Challenges in Veterinary Sciences

Manuja¹

2015

Immunome Res

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Nanotechnology has opened up new vistas for applications in almost all the disciplines of veterinary and animal sciences. Zinc oxide (ZnO) has been used as an alternative to antibiotics in animal feed. It has also been widely used for wound healing and various skin disorders. Recently ZnO nanoparticles (NPs) have attracted attention owing to their unique features. There can be numerous applications of ZnO NPs due to their antibacterial, antineoplastic, wound healing, ultraviolet scattering and angiogenic properties. These have also been used to promote tissue repair, as a food preservative and as feed additive. This paper reviews the recent developments in ZnO NPs research and its potential for application in animal health and production.

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Antibacterial Effect of Zinc Oxide in Vitro

Cited by 89 publications

References 7 publications

Growth-promoting efficacy of pharmacological doses of tetrabasic zinc chloride in diets for nursery pigs

Growth-promoting efficacy of pharmacological doses of tetrabasic zinc chloride in diets for nursery pigs

Soluções de óxido de zinco e de nitrato de prata como alternativa para antissepsia de tetos de bovinos (teste in situ)

Zinc Oxide Nanoparticles: Opportunities and Challenges in Veterinary Sciences

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