Antibacterial Effectiveness of 2 Root Canal Irrigants in Root-filled Teeth with Infection: A Randomized Clinical Trial

Zandi, Homan; Rodrigues, Renata Costa Val; Kristoffersen, Anne Karin; Enersen, Morten; Mdala, Ibrahimu; Ørstavik, Dag; Rôças, Isabela N.; Siqueira, José F.

doi:10.1016/j.joen.2016.06.006

Cited by 91 publications

(94 citation statements)

References 54 publications

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“…The relatively high occurrence of E. faecalis in the present study may be related to food and oral hygiene in the studied population (Zehnder & Guggenheim 2009). In line with earlier reports, there was no apparent selection of any 'hard to eliminate' taxa such as E. faecalis observed in the current study (Zandi et al 2016).…”

Section: Discussionsupporting

confidence: 94%

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Safety assessment of an etidronate in a sodium hypochlorite solution: randomized double‐blind trial

et al. 2019

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Aim To assess whether Dual Rinse HEDP, an etidronate that can be combined with NaOCl to create an endodontic irrigating solution containing both hypochlorite and a chelator in the form of 1‐hydroxyethane 1,1‐diphosphonic acid (HEDP), alters the clinical efficacy of NaOCl or adds any untoward clinical effects. Methodology In this randomized controlled double‐blind single‐centre trial, a pure NaOCl solution was compared to a HEDP‐containing counterpart regarding antimicrobial efficacy, postoperative pain, and the host response by means of changes in MMP‐9 levels in periapical fluid. Sixty patients presenting with asymptomatic apical periodontitis (one tooth each) were randomly divided into two groups (N = 30) based on irrigation regime. Pre‐ and post‐treatment microbial aerobic and anaerobic cultures and MMP‐9/total protein (TP) periapical fluid samples were collected. Postoperative pain levels were assessed 24 h after treatment. Categorical data were compared between groups using the Fisher's exact test, continuous data using the Wilcoxon signed‐rank test, α = 0.05. Results Irrigation with pure NaOCl rendered 40% canals free of culturable microorganisms, compared to 50% with the NaOCl/HEDP mixture (P = 0.60). As assessed by matrix‐assisted laser desorption/ionization‐time‐of‐flight analysis (MALDI‐TOF), no apparent selection of aerobic or anaerobic taxa occurred in either group. One patient in the NaOCl group experienced moderate pain, whilst two patients in the NaOCl/HEDP group experienced mild postoperative pain. MMP‐9/TP levels in periapical fluid declined significantly (P < 0.001) after 1 week with no medication in the root canal, without significant difference between treatment groups (P > 0.05). Conclusions This trial found no influence of HEDP on clinical NaOCl effects.

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Section: Discussionsupporting

confidence: 94%

“…In line with earlier reports, there was no apparent selection of any ‘hard to eliminate’ taxa such as E. faecalis observed in the current study (Zandi et al . ).…”

Section: Discussionmentioning

confidence: 97%

Safety assessment of an etidronate in a sodium hypochlorite solution: randomized double‐blind trial

et al. 2019

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“…After being the magical antibacterial irrigant over the years, NaOCL is the best choice when the bacterial reduction is required [23, 24]. However, its cytotoxic effects restrict its use in certain biological experiences; efforts have been made to find alternatives [25, 26].…”

Section: Discussionmentioning

confidence: 99%

The Use of Different Irrigation Techniques to Decrease Bacterial Loads in Healthy and Diabetic Patients with Asymptomatic Apical Periodontitis

Ghoneim

Saber

El-Badry³

et al. 2016

Open Access Maced J Med Sci

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BACKGROUND:Diabetes mellitus is a multisystem disease which weakens the human’s immunity. Subsequently, it worsens the sequelae of apical periodontitis by raising a fierce bacterial trait due to the impaired host response.AIM:This study aimed to estimate bacterial reduction after using different irrigation techniques in systemically healthy and diabetic patients with asymptomatic apical periodontitis.MATERIAL AND METHODS:Enterococcus faecalis, Peptostreptococcus micros, and Fusobacterium necleatum bacteria were chosen, as they are the most common and prevailing strains found in periodontitis. Bacterial samples were retrieved from necrotic root canals of systemically healthy and diabetic patients, before and after endodontic cleaning and shaping by using two different irrigation techniques; the conventional one and the EndoVac system. Quantitive polymerase chain reaction (qPCR) was utilised to detect the reduction in the bacterial count.RESULTS:The EndoVac irrigation system was effective in reducing bacteria, especially Peptostreptococcus micros in the diabetic group when compared to conventional irrigation technique with a statistically significant difference.CONCLUSION:The EndoVac can be considered as a promising tool in combination with irrigant solution to defeat the bacterial colonies living in the root canal system. Additional studies ought to be done to improve the means of bacterial clearance mainly in immune-compromised individuals.

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“…CHX has been recommended as root canal irrigant based on its antibacterial effects (Zandi et al, ) and substantivity, which allows prolonged residual effect (Souza et al, ). However, CHX does not dissolve organic tissues (Okino, Siqueira, Santos, Bombana & Figueiredo, ).…”

Section: Introductionmentioning

confidence: 99%

Cleaning capacity of octenidine as root canal irrigant: A scanning electron microscopy study

Coaguila‐Llerena

Silva

Tanomaru-Filho

et al. 2018

Microscopy Res & Technique

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The aim of this study was to assess the cleaning capacity of the octenidine hydrochloride (OCT) used as root canal irrigant by scanning electron microscopy (SEM) analysis. Sixty human unirradicular extracted teeth were randomly distributed in 6 groups (n = 10) according to irrigant solutions which were used during root canal preparation: G1, 0.1% OCT; G2, 2% chlorhexidine (CHX); G3, 2.5% sodium hypochlorite (NaOCl); G4, OCT + 17% ethylenediaminetetraacetic acid (EDTA); G5, 2.5% NaOCl + 17% EDTA and G6, distilled water. All specimens were instrumented with ProTaper system up to F4. Teeth were sectioned and prepared for SEM. The smear layer was evaluated using a 5-score system and the data were analyzed by Kruskal-Wallis and Dunn (α = 0.05). In all root canal thirds there was no significant difference between OCT, CHX, NaOCl, and water groups (p > .05), and these groups showed higher smear layer values than NaOCl + EDTA and OCT + EDTA groups (p < .05). There was no significant difference between NaOCl + EDTA and OCT + EDTA groups (p > .05). It was concluded that OCT used as a single root canal irrigant presented poor cleaning capacity and could be used in association with a final irrigation with EDTA to obtain smear layer removal.

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Antibacterial Effectiveness of 2 Root Canal Irrigants in Root-filled Teeth with Infection: A Randomized Clinical Trial

Cited by 91 publications

References 54 publications

Safety assessment of an etidronate in a sodium hypochlorite solution: randomized double‐blind trial

Safety assessment of an etidronate in a sodium hypochlorite solution: randomized double‐blind trial

The Use of Different Irrigation Techniques to Decrease Bacterial Loads in Healthy and Diabetic Patients with Asymptomatic Apical Periodontitis

Cleaning capacity of octenidine as root canal irrigant: A scanning electron microscopy study

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