Antibacterial effects and biocompatibility of titanium surfaces with graded silver incorporation in titania nanotubes

Mei, Shenglin; Wang, Huaiyu; Wang, Wei; Tong, Liping; Pan, Haobo; Ruan, Changshun; Ma, Qianli; Liu, Meng‐Yuan; Yang, Huiling; Zhang, Liang; Cheng, Yicheng; Zhang, Yumei; Zhao, Lei; Chu, Paul K.

doi:10.1016/j.biomaterials.2014.02.005

Cited by 345 publications

(192 citation statements)

References 39 publications

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“…In vivo tests on this subject are sparse and have only been performed for ion-implanted 117) , silicon 97) , Ag and AgNP surfaces 63,78,84,175) . To our knowledge, drug-loaded, nitrided, AMP, polymer surfaces (except for silicon) and UV-activated dental implant surfaces have not yet advanced to in vivo validation.…”

Section: Discussionmentioning

confidence: 99%

“…Silver exhibits a rather broad spectrum of antimicrobial activity and has not yet increased the risk of bacterial resistance. Pathogens found at infected oral implant sites, including S. mutans 90) , S. aureus 93,94) , S. oralis 43) , P. gingivalis and A. actinomycetemcomitans 84) were killed or significantly reduced upon contact with silver-implanted surfaces. All tested silver surfaces, such as hydroxyapatite (HA)-silver-surfaces 42,44,[46][47][48][49][50][51]91,161) or plasma sprayed silver-implanted HA 45,95) shared good antimicrobial activity.…”

Section: Silver-implanted Surfacesmentioning

confidence: 99%

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Antimicrobial dental implant functionalization strategies —A systematic review

Grischke

Eberhard

Stiesch

2016

Dental Materials Journal

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Section: Discussionmentioning

confidence: 99%

Section: Silver-implanted Surfacesmentioning

confidence: 99%

Antimicrobial dental implant functionalization strategies —A systematic review

Grischke

Eberhard

Stiesch

2016

Dental Materials Journal

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“…As well, comparing Ag + release data and corresponding in vitro or in vivo response in the literature should be done cautiously, as quantification methods tend to vary among studies. The cytotoxicity and tissue cell response of novel Ag-TiO 2 nanotube coatings have been evaluated in recent studies, and demonstrated that a controlled release of Ag + can have sufficient antibacterial effect while maintaining, or in some instances even improving the biocompatibility [36,38,56]. The biological evaluation of the gradient coating presented in this work was limited to the effect against S. aureus bacteria, precluding the authors from drawing any conclusions regarding the mammalian cell response to the amount of Ag + released.…”

Section: Discussionmentioning

confidence: 99%

Reactive combinatorial synthesis and characterization of a gradient Ag–Ti oxide thin film with antibacterial properties

et al. 2015

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Growing demand for orthopedic and dental implants has spurred researchers to develop multifunctional coatings, combining tissue integration with antibacterial features. A possible strategy to endow titanium (Ti) with antibacterial properties is by incorporating silver (Ag), but designing a structure with adequate Ag + release while maintaining biocompatibility has been shown difficult. To further explore the composition-structure-property relationships between Ag and Ti, and its effects against bacteria, this study utilized a combinatorial approach to manufacture and test a single sample containing a binary Ag-Ti oxide gradient. The sample, sputter deposited in a reactive (O 2 ) environment using a custom built combinatorial physical vapor deposition (PVD) system, was shown to be effective against Staphylococcus aureus with viability reductions ranging from 17 to above 99 %, depending on amount of Ag + released from its different parts. The Ag content along the gradient ranged from 35 to 62 wt%, but it was found that structural properties such as varied porosity and degree of crystallinity, rather than amount of incorporated Ag governed the Ag + release and resulting antibacterial activity. The coating also demonstrated in vitro apatite forming abilities, where structural variety along the sample was shown to alter the hydrophilic behavior, with degree of hydroxyapatite (HA) deposition varying accordingly. By means of combinatorial synthesis, a single gradient sample was able to display intricate compositional and structural features affecting its biological response, which would otherwise require a series of coatings. The current findings suggest that future implant coatings incorporating Ag as an antibacterial agent could be structurally enhanced to better suit clinical requirements.

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“…Titania nanotubes (TNT) have also been used for studying implant associated infections and have shown to spectacularly inhibit biofilm formation on implant surfaces [12]. Various investigations also state the use of TNT based drug delivery to greatly assist in hindering implant associated infections [13,14]. Similarly, the use of 25 ppm Selenium nanoparticles has been reported to inhibit almost 50% of Candida albicans biofilm, by substituting with sulfur and inducing cell structure damage.…”

Section: Discussionmentioning

confidence: 99%

Nano Based Therapy for Biofilm Management: Mini Review

Rawat¹

2017

JNMR

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High toxicity, low host tolerance, narrow spectrum of antifungal drugs and increasing incidence of azole-resistance complicates treatment of invasive Candida infections. Due to the emergence of antimicrobial resistance as an increasing threat to global health care, arises the need to develop new, and effective broad spectrum active antifungal agents. Thus understanding and combating drug resistance in Candida albicans is a toughest challenge being faced today and it's immensely important to develop an alternative coating that can inhibit biofilm formation on medical devices as implants and catheters. Additionally, the fascinating properties of nanomaterials and biocompatibility promises great potential in nanomedical applications, especially in medical microbiology. With appropriate modification of these synthetic materials, several disease infections can be cured and results have shown the use of these nanomaterials as diagnostic and immunotherapauetic agents. Since, antimicrobial resistance is becoming a major apprehension worldwide, nanomedicines offer an intriguing and promising solution for combating these high resistance pathogens by appropriate development of therauptic and novel diagnosis approaches. This mini review presents the current state of art in this emerging field.

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Antibacterial effects and biocompatibility of titanium surfaces with graded silver incorporation in titania nanotubes

Cited by 345 publications

References 39 publications

Antimicrobial dental implant functionalization strategies —A systematic review

Antimicrobial dental implant functionalization strategies —A systematic review

Reactive combinatorial synthesis and characterization of a gradient Ag–Ti oxide thin film with antibacterial properties

Nano Based Therapy for Biofilm Management: Mini Review

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