Antibacterial effects of electrospun chitosan/poly(ethylene oxide) nanofibrous membranes loaded with chlorhexidine and silver

Song, Jiankang; Remmers, Stefan; Shao, Jinlong; Kolwijck, Eva; Walboomers, X. Frank; Jansen, John A.; Leeuwenburgh, Sander C. G.; Yang, Fang

doi:10.1016/j.nano.2016.02.005

Cited by 51 publications

(29 citation statements)

References 34 publications

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“…También, Rieger et al [16], demostraron que las nanofibras de quitosano/CA/PEO pueden servir como vehículos de suministro de Cinamaldehido (CA) que potencialmente erradican las infecciones causadas por pseudomonas. Song et al [17], prepararon una membrana electrohilada de quitosano/poli(óxido de etileno) (PEO) que contenía nanopartículas de plata como un vehículo de administración implantable para la liberación dual de iones de clorhexidina y plata. Este estudio se realizó para prevenir las infecciones percutáneas.…”

Section: Introductionunclassified

Preparación y caracterización de membranas poliméricas electrohiladas de policaprolactona y quitosano para la liberación controlada de clorhidrato de tiamina / Preparation and Characterization of Electrospun Polymeric Membranes of Polycaprolactone and Chitosan for Controlled Release of Thiamine Chlorhydrate

Cepeda

2016

Cienc. En Desarro.

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ResumenActualmente existen importantes investigaciones sobre la preparación de membranas porosas bioabsorbibles que permiten la liberación controlada de fármacos y vitaminas. En este estudio se propuso preparar membranas porosas a partir de policaprolactona (PCL) y quitosano (CS) bajo la técnica de electrohilado aplicando diferentes parámetros con el fin de evaluar sus características internas y propiedades para una potencial aplicación como liberador del clorhidrato de tiamina (Vitamina B 1 ). Además se desarrolló el estudio de la cinética de liberación In vitro del clorhidrato de tiamina (TC) con las membranas preparadas. Se obtuvo una membrana polimérica a partir de una disolución de

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Section: Introductionunclassified

Preparación y caracterización de membranas poliméricas electrohiladas de policaprolactona y quitosano para la liberación controlada de clorhidrato de tiamina / Preparation and Characterization of Electrospun Polymeric Membranes of Polycaprolactone and Chitosan for Controlled Release of Thiamine Chlorhydrate

Cepeda

2016

Cienc. En Desarro.

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“…To examine the antibacterial effect of the various electrospun SF fibrous membranes (Table ), we performed the zone of inhibition test against S. aureus (ATCC 25923TM, Manassas, USA) . An obvious inhibition zone was observed for all the intact membranes loaded with vancomycin (Figure d–f).…”

Section: Resultsmentioning

confidence: 99%

“…Among these nanocarriers, electrospun nanofibers have been explored for drug delivery purposes due to their high drug loading and encapsulation efficiency, ability to modulate the release of biomolecules, cost‐effectiveness, and ease of processing. [8b,9] More recently, silk fibroin (SF) has gained interest as a biomaterial due to several beneficial properties such as its biocompatibility, biodegradability, and its processability into multiple shapes including nanofibers . Such nanofibers can be further crosslinked by water annealing to improve their chemical and mechanical stability.…”

Section: Introductionmentioning

confidence: 99%

Electrospun Nanofibrous Silk Fibroin Membranes Containing Gelatin Nanospheres for Controlled Delivery of Biomolecules

Song

Klymov

Shao

et al. 2017

Adv Healthcare Materials

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Development of novel and effective drug delivery systems for controlled release of bioactive molecules is of critical importance in the field of regenerative medicine. Here, oppositely charged gelatin nanospheres are incorporated into silk fibroin nanofibers through a colloidal electrospinning technique. A novel fibrous nano-in-nano drug delivery system is fabricated without the use of any organic solvent. The distribution of fluorescently labeled gelatin A and B nanospheres inside the nanofibers can be fine-tuned by simple adjustment of the weight ratio between the nanospheres and the relative feeding rate of core and shell solutions containing nanospheres by using single and coaxial nozzle electrospinning, respectively. Incorporation of vancomycin-loaded gelatin B nanospheres into the silk fibroin nanofibrous membranes results in a more sustained release of vancomycin, compared to the gelatin nanospheres free membranes. In addition, these membranes exhibit excellent and prolonged antibacterial effects against Staphylococcus aureus. Moreover, these membranes support the attachment, spreading, and proliferation of periodontal ligament cells. These results suggest that the beneficial properties of gelatin nanospheres can be exploited to improve the biological functionality of electrospun nanofibrous silk fibroin membranes.

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“…Once the structure or function of the skin is defective, the body is susceptible to microbial invasion and wound infection, which delays wound healing and may even endanger life [4]. Surgery, burns, or chronic diseases can damage skin integrity, affect homeostasis, and cause wound infection [5]. However, wound healing is a very complicated process, and both acute and chronic skin injury treatments face great challenges in clinical practice [6].…”

Section: Introductionmentioning

confidence: 99%

“…(1) It has good moisture absorption (2) It can effectively maintain exudate around the wound but does not form effusion (3) It has light adhesion to wound tissue and is not easy to scab, which can reduce the damage to new tissue when the dressing is removed (4) The raw materials used have certain antibacterial properties, showing good antibacterial effects (5) It can prevent wound infection again, which is unlikely to cause disease (6) The dressing materials should be biocompatible, absorb excess exudates, and possess bioactive properties to promote wound healing (e.g., antibacterial behavior) [13,14].…”

Section: Introductionmentioning

confidence: 99%

Advances in Electrospinning of Natural Biomaterials for Wound Dressing

Fa-dong

Jia

et al. 2020

Journal of Nanomaterials

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Electrospinning has been recognized as an efficient technique for the fabrication of polymer nanofibers. Various polymers have been successfully electrospun into ultrafine fibers in recent years. These electrospun biopolymer nanofibers have potential applications for wound dressing based upon their unique properties. In this paper, a comprehensive review is presented on the researches and developments related to electrospun biopolymer nanofibers including processing, structure and property, characterization, and applications. Information of those polymers together with their processing condition for electrospinning of ultrafine fibers has been summarized in the paper. The application of electrospun natural biopolymer fibers in wound dressings was specifically discussed. Other issues regarding the technology limitations, research challenges, and future trends are also discussed.

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Antibacterial effects of electrospun chitosan/poly(ethylene oxide) nanofibrous membranes loaded with chlorhexidine and silver

Cited by 51 publications

References 34 publications

Electrospun Nanofibrous Silk Fibroin Membranes Containing Gelatin Nanospheres for Controlled Delivery of Biomolecules

Advances in Electrospinning of Natural Biomaterials for Wound Dressing

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