Antibacterial Effects of Juglone and Its Derivatives against Oral Pathogens

Jeon, Ju-Hyun; Lee, Chi-Hoon; Kim, Myung Kon; Lee, Hoi-Seon

doi:10.3839/jksabc.2009.119

Cited by 14 publications

(8 citation statements)

References 15 publications

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“…The antimicrobial activity of naphthoquinones has been reported in several studies [ 25 , 58 – 61 ]. Juglone has been shown to act against the marine bioluminescent species, Vibrio fischeri , and the dinoflagellate, Glenodinium foliaceum [ 25 ].…”

Section: Resultsmentioning

confidence: 99%

Anti-Biofilm Performance of Three Natural Products against Initial Bacterial Attachment

Salta

Wharton

Dennington

et al. 2013

IJMS

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Marine bacteria contribute significantly towards the fouling consortium, both directly (modern foul release coatings fail to prevent “slime” attachment) and indirectly (biofilms often excrete chemical cues that attract macrofouling settlement). This study assessed the natural product anti-biofilm performance of an extract of the seaweed, Chondrus crispus, and two isolated compounds from terrestrial sources, (+)-usnic acid and juglone, against two marine biofilm forming bacteria, Cobetia marina and Marinobacter hydrocarbonoclasticus. Bioassays were developed using quantitative imaging and fluorescent labelling to test the natural products over a range of concentrations against initial bacterial attachment. All natural products affected bacterial attachment; however, juglone demonstrated the best anti-biofilm performance against both bacterial species at a concentration range between 5–20 ppm. In addition, for the first time, a dose-dependent inhibition (hormetic) response was observed for natural products against marine biofilm forming bacteria.

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Section: Resultsmentioning

confidence: 99%

Anti-Biofilm Performance of Three Natural Products against Initial Bacterial Attachment

Salta

Wharton

Dennington

et al. 2013

IJMS

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“…Diospyros usambarensis root bark: The antibacterial activity of 7-methyljuglone exhibited against oral pathogenic bacteria: Streptococcus sp. and Porphyromonas [17] and Diospyros species possession of naphthaquinones [18] justify the use of root bark for oral hygiene and as a teeth whitener.…”

Section: Beauty Products From Plant Sources: Previous Reports On Usesmentioning

confidence: 99%

Documentation and Phytochemical Screening of Traditional Beauty Products Used in Missenyi District of Tanzania

Maregesi¹,

Kagashe²,

Felix³

2014

JCDSA

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Background Information: The concept of beauty and cosmetics is as old as mankind and civilization. Raw materials for beauty products are dominated by petroleum and synthetic products. In recent years, there has been an increase of natural product-based cosmetics along with creating beauty from the inside by consumption of nutraceuticals. Tanzania traditional beauty products are still in use especially rural areas, but the documentation is lacking. Objectives: This work aimed at documenting traditional beauty products in Kagera region as an effort to avoid loss of useful information and available useful traditional findings for safe utilization in beauty products. Methodology: Information was obtained from knowledgeable people in Missenyi district by focus group discussion. Collected materials were identified in Botany and Zoology Departments at the University of Dar es Salaam followed by literature search and phytochemical screening. Results: This study afforded to record 13 plants, 4 animal products, mineral and other organic products. Most products are used for skin care (57%) followed by hair care (22%). Literature search supported the use of some of the products and plants subjected to qualitative analysis showed presence of phytochemicals relevant to beautification. Discussion: Some of the recorded plant and animal products are incorporated in natural based cosmetic products. Hazardous practice of using skin lightening plant products and dry cell powders was noted. Conclusion: The use of products which are already incorporated in the cosmetic products especially in countries where these products are well regulated should be promoted. Products reported for the first time require scientific studies to establish their effectiveness and safety. Since this study recorded the use of some dangerous materials, people need to be educated through media.

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“…1,6) The range of biological effects of natural and synthetic 1,4-naphthoquinones is diverse and includes antimicrobial, antifungal, antiviral, antiprotozoal, wound healing, cytotoxic, antitumor and some other properties. [7][8][9][10][11][12][13][14][15] Historically, natural naphthoquinones such as lawsone (2), juglone (3) and lapachol (5) were among the first to be investigated. 6) Lawsone (2), one of the best-known naphthoquinones, was isolated from a tropical shrub Lawsonia inermis (henna).…”

Section: Biological Activity Of 14-naphthoquinonesmentioning

confidence: 99%

“…4) and other related products active in vitro in human leukemia HL60 cells. 22,23) The glycosides (10) and (11) were evaluated in vivo for their antitumor activity in mouse Ehrlich ascites carcinoma. The most effective glucoside (10) increased the average lifespan of mice by a factor of two or longer.…”

Section: Biological Activity Of 14-naphthoquinonesmentioning

confidence: 99%

“…22,23) The glycosides (10) and (11) were evaluated in vivo for their antitumor activity in mouse Ehrlich ascites carcinoma. The most effective glucoside (10) increased the average lifespan of mice by a factor of two or longer. 24) Another representative compound of the naphthazarine series used in medicine is shikonin (14)-a quinone secondary metabolite produced by the plant Lithospermum erythrorhizon (red root).…”

Section: Biological Activity Of 14-naphthoquinonesmentioning

confidence: 99%

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1,4-Naphthoquinones: Some Biological Properties and Application

2020

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Over the past decade, a number of new 1,4-naphthoquinones have been isolated from natural sources and new 1,4-naphthoquinones with diverse structural features have been synthesized. Cardioprotective, antiischemic, hepatoprotective, neuroprotective and some other new properties were found for these compounds; their role in protecting against neurodegenerative diseases has been established. Their anti-inflammatory, antimicrobial and antitumor activities have been studied in more detail; new, previously unknown intracellular molecular targets and mechanisms of action have been discovered. Some compounds of this class are already being used as a medicinal drugs and some substances can be used as biochemical tools and probes for non-invasive detection of pathological areas in cells and tissues in myocardial infarction and neurodegenerative diseases using modern molecular imaging techniques.

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Antibacterial Effects of Juglone and Its Derivatives against Oral Pathogens

Cited by 14 publications

References 15 publications

Anti-Biofilm Performance of Three Natural Products against Initial Bacterial Attachment

Anti-Biofilm Performance of Three Natural Products against Initial Bacterial Attachment

Documentation and Phytochemical Screening of Traditional Beauty Products Used in Missenyi District of Tanzania

1,4-Naphthoquinones: Some Biological Properties and Application

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