Antibacterial effects of sol‐gel‐derived bioactive glass nanoparticle on aerobic bacteria

Abstract

The aim of this work was to evaluate the antibacterial effect of bioactive glass nanopowders. The 58S, 63S, and 72S compositions were prepared via the sol-gel technique. Characterization techniques such as X-ray diffraction, transmission electron microscopy (TEM), Zetasizer, and X-ray fluorescent were used. The antibacterial activity was studied using Escherichia coli, Pseudomonas aeruginosa, Salmonella typhi, and Staphylococcus aureus. Cytotoxicity of the samples was evaluated using mouse fibroblast L929 cell line. The chemical compositions of the prepared samples were as predicted, and the particle size of the samples with an amorphous structure mainly ranged over 20-90 nm. At broth concentrations below 50 mg/mL, they showed no antibacterial activity. The 58S showed the highest antibacterial activity with the minimum bactericidal concentrations of 50 and 100 mg/mL for E. coli plus S. aureus and for P. aeruginosa, respectively. The 63S exhibited bactericidal and bacteriostatic effects on E. coli and S. aureus at concentrations of 100 and 50 mg/mL, respectively, at an minimum bactericidal concentrations of 100 mg/mL. However, 72S bioactive glass nanopowder showed no antibacterial effect. They showed no cytotoxicity. It was concluded that bioactive glass nanopowders could be considered as good candidates for the treatment of oral bone defects and root canal disinfection. (c) 2010 Wiley Periodicals, Inc. J Biomed Mater Res, 2010.

ZnO quantum dots modified bioactive glass nanoparticles with pH-sensitive release of Zn ions, fluorescence, antibacterial and osteogenic properties

“…silver, cerium ions) or alkaline ions leading to local pH rise. [56][57][58] ZnO QDs are effective antibacterial agents, and their antibacterial activity is considered to be from the production of H 2 O 2 from ZnO QDs, the release of Zn ions, or the generation of reactive oxygen species (ROS). 59 The reported minimum inhibition concentration (MIC) of Zn ions against S. aureus was lower than 9 mg mL…”

Multifunctional and biomimetic fish collagen/bioactive glass nanofibers: fabrication, antibacterial activity and inducing skin regeneration in vitro and in vivo

“…This antibacterial effect may be related to the addition of BG, which may exert this effect by its chemical composition and the dissolution conditions in its surroundings. 11 The released ions (such as Ca, P and Si) can increase the osmotic pressure, creating an environment where the bacteria cannot grow. 23,24 In order to further verify the ions released by the Col/BG nanofibers, inductively coupled plasma emission spectrometry was used to detect the concentration of ions in the BHI; the results showed that the Col/BG nanofibers released a certain amount of Ca, P and Si ions ( Table 2).…”

“…10 BG also has been found to exert an antibacterial effect when challenged with bacteria in some studies. [11][12][13] Therefore, the development of a skin wound dressing with fish collagen and BG seemed to be extremely interesting. It was necessary to study the amount of BG added to fish collagen and the appropriate technology to make the composites achieve the anticipated multifunctional effects, including a certain tensile strength, antibacterial activity and the capability to effectively induce skin regeneration.…”

Copper-doped and copper-free bioactive glass nanopowders cytotoxicity and antibacterial activity assessment

“…BGs are more bioactive than calcium phosphate compounds; in addition, the silicabased BGs bioactivity reactions are faster than hydroxyapatite (HA). One of the most important characteristics of BGs is that they can provide an ideal environment for genetic control and stimulation of human osteoblasts to be proliferated and di erentiated as they lead to bone formation both in vitro and in vivo with rapid bone regeneration [1,14,15]. There are two processing methods for synthesizing BGs: traditional melt quenching and versatile sol-gel methods.…”

“…Between them, due to producing small glass particles with a high-surface area, increased resorption rate, and higher bioactivity, the sol-gel method is more attractive than the other [6,16,17]. Some of certain BGs have also shown the antibacterial e ect [1,18]. For instance, particulate Bioglass r is one of the materials which displays signi cant antibacterial e ect on certain oral bacteria [19].…”