Antibacterial Efficacy of Chlorhexidine Gluconate Intracanal Medication In Vivo

Paquette, Lisane; Legner, M.; Fillery, Edward D.; Friedman, Shimon

doi:10.1016/j.joen.2005.12.017

Cited by 62 publications

(92 citation statements)

References 32 publications

(162 reference statements)

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“…Therefore, biomechanical preparation, irrigation with different chemical solutions, and use of intracanal dressings are considered essential components for microbial control in endodontic infections (1)(2)(3)(4).…”

mentioning

confidence: 99%

Determination of para-Chloroaniline and Reactive Oxygen Species in Chlorhexidine and Chlorhexidine Associated with Calcium Hydroxide

Barbin

Saquy

Guedes

et al. 2008

Journal of Endodontics

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mentioning

confidence: 99%

Determination of para-Chloroaniline and Reactive Oxygen Species in Chlorhexidine and Chlorhexidine Associated with Calcium Hydroxide

Barbin

Saquy

Guedes

et al. 2008

Journal of Endodontics

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“…Komorowski et al [ 45 ] suggested that a 5-min application of CHX did not induce substantivity, so the dentin should be treated with CHX for 7 days. However, when Paquette et al [ 63 ] and Malkhassian et al [ 55 ] in their in vivo studies medicated the canals with either liquid or gel forms of CHX for 1 week, neither of them could achieve total disinfection. Therefore, residual antimicrobial effi cacy of CHX in vivo still remains to be demonstrated.…”

Section: Substantivitymentioning

confidence: 99%

Update of Endodontic Irrigating Solutions

Basrani¹,

Malkhassian²

2015

Endodontic Irrigation

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Successful root canal therapy depends on thorough debridement of pulpal tissue, dentin debris, and infective microorganisms. Currently, it is impossible to predictably eradicate intraradicular infection with mechanical instrumentation alone. Therefore, irrigants are required to be used as an important addition in the disinfection process. This chapter analyzes the main irrigating solutions used during the endodontic treatment and their actions and interactions among them. Explanation of their mechanism of action and effect on dentin structure and on biofi lm is also described. A clinical protocol is proposed at the end of the chapter.The goal of endodontic treatment is to prevent or cure apical periodontitis. Apical periodontitis is an infl ammatory process in the periradicular tissues caused by microorganisms in the infected root canal [ 84 ]. It is well known that shaping, cleaning, and obturating the root canal system provide the strategy for successful treatment. The principle to reach favorable outcomes in endodontic infection management requires the recognition of the problem and the removal of the etiological factors.In endodontic disinfection, there are two main challenges which are important to be recognized the anatomical challenge and the microbiological challenge [ 42 ].The anatomical challenge can be divided into complexity of the root canal system, dentin structure, and dentin constituents. Anatomical Complexities (also see Chap. 2 ):Root canal is an enclosed complex space with intricate confi gurations and apical constriction it is important to mention here that more than 35 % of the root canal surface is left untouched by conventional instrumentation [ 35 , 64 ] (Fig. 5.1 ). Also, common instrumentation techniques accumulate debris in isthmus areas. Paque et al. showed explained that when rotary fi les are used in canal with a round cross section, the dentine particles that are cut from the canal wall are car-

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“…Clinical studies have shown that it is effective when used with 1% hypochlorite solution (Zamany et al, 2003), and in vitro studies have shown superiority compared with calcium hydroxide usage or controls (Cook et al, 2007). However, other studies have not corroborated its absolute efficacy as an irrigant or a medicament between appointments (Manzur et al, 2007;Paquette et al, 2007;Tervit et al, 2009). Chlorhexidine also interfered with cell attachment to dentin in vitro, although not to the same extent as hypochlorite (Ring et al, 2008).…”

Section: Inefficacy and Potential Detrimental Effects Of Traditional mentioning

confidence: 99%

The Microbial Challenge to Pulp Regeneration

Fouad

2011

Adv Dent Res.

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Pulp regeneration is considered in cases where the dental pulp has been destroyed because of microbial irritation. Diverse oral and food-borne micro-organisms are able to invade the pulp space, form biofilm on canal walls, and infiltrate dentinal tubules. Prior to pulp regeneration procedures, the pulp space and dentinal walls need to be sufficiently disinfected to allow for and promote regeneration. The necessary level of disinfection is likely higher than that accepted for traditional endodontic therapy, because in traditional techniques the mere lowering of bacterial loads and prevention of bacterial access to periapical tissues is conducive to healing. Moreover, several of the non-specific antimicrobials used in traditional endodontic therapy may cause significant changes in remaining dentin that interfere with its inherent potential to mediate regeneration. Non-specific antimicrobials also suppress all microbial taxa, which may allow residual virulent micro-organisms to preferentially repopulate the pulp space. Therefore, it is important for endodontic pathogens to be studied by molecular methods that allow for a broad depth of coverage. It is then essential to determine the most effective protocols to disinfect the pulp space, with minimal disruption of remaining dentin. These protocols include the topical use of effective antibiotics, including newer agents that have demonstrated efficacy against endodontic pathogens.

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Antibacterial Efficacy of Chlorhexidine Gluconate Intracanal Medication In Vivo

Cited by 62 publications

References 32 publications

Determination of para-Chloroaniline and Reactive Oxygen Species in Chlorhexidine and Chlorhexidine Associated with Calcium Hydroxide

Determination of para-Chloroaniline and Reactive Oxygen Species in Chlorhexidine and Chlorhexidine Associated with Calcium Hydroxide

Update of Endodontic Irrigating Solutions

The Microbial Challenge to Pulp Regeneration

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