Antibacterial efficacy of silver diamine fluoride as a root canal irrigant

Abstract

ObjectivesConventional disinfectants and medicaments have not been able to achieve and maintain sterilization of root canals. The purpose of the study was to evaluate the antibacterial efficacy of 3.8% silver diamine fluoride (SDF) in comparison with 2% chlorhexidine (CHX) against Enterococcus faecalis biofilm.Materials and methodsExtracted human teeth were used to make 70 dentin discs that were then inoculated with E. faecalis to generate a 3‐week‐old biofilm model. The discs were subjected to treatment with 3.8% SDF, 2% CHX, sodium hypochlorite (NaOCl), or saline for 10 min. After exposure, the dentin discs were examined with a confocal laser scanning microscope to verify the percentage of live versus dead cells within the biofilm. Univariate one‐way analysis of variance and Tukey‐honestly significant difference post hoc analysis (p < .05) were performed to detect significant differences.Results and conclusionThe NaOCl group showed the greatest percentage of dead cells (62.26%) among all groups (p < .05). The SDF group showed a significantly higher percentage of dead cells (57.39%) than the 2% CHX and saline groups (p < .05). SDF possessed higher antimicrobial activity than 2% CHX against E. faecalis biofilms.

Antimicrobial and Physicochemical Properties of Artificial Saliva Formulations Supplemented with Core-Shell Magnetic Nanoparticles

“…Moreover, several studies proved their potential as antimicrobial agents that prevent biofilm formation [28,29]. To date, among metallics' nanomaterials, usage in the area of dentistry silver and gold particles has been successfully engaged [30][31][32]. To the best of our knowledge, this is the first study where core-shell magnetic nanoparticles were proposed and tested as a component of artificial saliva preparation to improve their 3 of 17 antimicrobial activity.…”

Evidence‐Based Bibliometric Analysis of Research on Silver Diamine Fluoride Use in Dentistry

“…The diamine-silver ion is a complex ion with two ammonia molecules connected to a silver ion. The fluoride in the SDF has a well-proven track record for exaggerating the remineralization of enamel and dentine [ 11 ], whereas the silver has been proven to have a strong antibacterial activity [ 12 ].…”

Metodologías complementarias para la evaluación de dientes tratados endodónticamente restaurados con pernos prefabricados: revisión narrativa de la literatura

“…Los irrigantes, además de tener acción física y química sobre la dentina, también puede ofrecer un efecto bactericida / bacteriostático. En este contexto, no son frecuentes los estudios en la literatura que hacen un abordaje que correlacione la RDTE con la reducción de microorganismos tras el uso de soluciones irrigantes 83 . Dentro de las técnicas presentadas, la técnica de cultivo de microorganismos parece ser la más adecuada para este tipo de estudios, asociada o no al uso de técnicas de espectrofotometría para la evaluación de biopelículas 84 .…”

“…La presencia de fibras de colágeno, smear-layer y la evaluación cualitativa de las fracturas después de las pruebas de resistencia de la unión se pueden realizar con éxito utilizando MEB 96,97 . La microscopía confocal es un método útil para comprobar el cemento en los túbulos dentinarios y para comprobar la presencia de microorganismos 83,98 .…”