Antibacterial Interaction of Crude Methanol Extract of &lt;i&gt;Garcinia kola&lt;/i&gt; Seed with Gatifloxacin

Ofokansi, KC; Mbanefo, AN; Ofokansi, MN; Esimone, CO

doi:10.4314/tjpr.v7i4.14702

Cited by 9 publications

(4 citation statements)

References 6 publications

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“…It is well demonstrated that the efflux pumps reduce the intracellular concentration of antibiotics and consequently their activities [ 57 ]. The MDR bacteria strains used in this paper are known for their ability to overexpress active efflux [ 58 ]. At MIC/2, synergistic effects were noted with the association of NOR, CHL, TET (on 100% the studied bacteria), ERY (on 80%), CIP (on 70%), and P. nitida extract meanwhile G. kola extract also increased the activity of NOR, TET (on 100%), ERY, and CIP (on 70%).…”

Section: Discussionmentioning

confidence: 99%

Antibacterial Activities of Selected Cameroonian Plants and Their Synergistic Effects with Antibiotics against Bacteria Expressing MDR Phenotypes

Lacmata

Kuete

Dzoyem

et al. 2012

Evidence-Based Complementary and Alternative Medicine

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The present work was designed to assess the antibacterial properties of the methanol extracts of some Cameroonian medicinal plants and the effect of their associations with currently used antibiotics on multidrug resistant (MDR) Gram-negative bacteria overexpressing active efflux pumps. The antibacterial activities of twelve methanol extracts of medicinal plants were evaluated using broth microdilution. The results of this test showed that three extracts Garcinia lucida with the minimal inhibitory concentrations (MIC) varying from 128 to 512 μg/mL, Garcinia kola (MIC of 256 to 1024 μg/mL), and Picralima nitida (MIC of 128 to 1024 μg/mL) were active on all the twenty-nine studied bacteria including MDR phenotypes. The association of phenylalanine arginine β-naphthylamide (PAβN or efflux pumps inhibitor) to different extracts did not modify their activities. At the concentration of MIC/2 and MIC/5, the extracts of P. nitida and G. kola improved the antibacterial activities of some commonly used antibiotics suggesting their synergistic effects with the tested antibiotics. The results of this study suggest that the tested plant extracts and mostly those from P. nitida, G. lucida and G. kola could be used alone or in association with common antibiotics in the fight of bacterial infections involving MDR strains.

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Section: Discussionmentioning

confidence: 99%

Antibacterial Activities of Selected Cameroonian Plants and Their Synergistic Effects with Antibiotics against Bacteria Expressing MDR Phenotypes

Lacmata

Kuete

Dzoyem

et al. 2012

Evidence-Based Complementary and Alternative Medicine

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“…Therapeutic Applications of Garcinia Kola: Antimicrobial Activity: Antimicrobial activities of crude extract of Garcinia kola against some bacterial isolates comprising of both Gram-positive and Gram-negative organisms had been reported 44 In another study, the antimicrobial interaction between G. kola seed and gatifloxacin, a fourthgeneration fluoroquinolone, was evaluated by a modification of the checkerboard technique 45 . The antimicrobial activity of five different solvent extracts of Garcinia kola seed had been investigated against 30 clinical strains of Helicobacter pylori and a standard control strain, NCTC 11638, using conventional microbiological techniques 46 .…”

Section: Fig 4: Some Chemical Constituents Of G Kolamentioning

confidence: 99%

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2016

IJPSR

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Medicinal plants are bioresources harnessed by humans to combat diseases and maintain a healthy life. Plants remain the basis for the development of modern drugs for the preservation of health. Garcinia kola is considered a "wonder plant" because every part of it has been found to be of medicinal importance. G. kola seed is used as an antipyretic agent in indigenous system of medicine. Pharmacologic studies on the seed, leaf, and root of this plant showed potent antimicrobial, antiviral, antiulcer, anti-inflammatory, antihepatotoxic, antidiabetic, antihypertensive, adaptogenic, aphrodisiac and antiasthma activities. This review highlights detailed pharmacological properties and phytochemistry of G. kola in an attempt to provide direction for further research toward drug discovery. INTRODUCTION:Medicinal plants occupy an important place in the therapeutic arsenal of humans. According to the world health organization over 80% of the world"s population, mostly in poor and less developed countries depend on traditional plant-based medicines for their primary health care needs 1 . Infectious diseases are the number one causes of death accounting for approximately one-half of all deaths in tropical countries. Many infectious diseases are known to have been treated with herbal remedies throughout the history of mankind 2 .

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“…The sap of G. kola is used for the treatment of parasitic skin diseases while the latex is orally ingested for the treatment of gonorrhoea. It is also useful in the eradication of guinea worm infestation (Ofakansi et al, 2008).…”

Section: Taxonomic Description Of Garcinia Kolamentioning

confidence: 99%

Possibility of using the intermediate mature stage of Garcinia kola heckel seeds to shorten the germination time

Edmond¹,

Anatole²,

Christophe³

et al. 2015

Afr. J. Agric. Res.

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Garcinia kola is used as chew-stick for dental care in West Africa. The species is nearly commercially extinct in nature, and its propagation is hampered by seed germination problems. The current study investigated seed germination responses of Garcinia kola at different maturity stage. The experiments were conducted at the Central Laboratory of Biotechnology of the Centre National de Recherche Agronomique (CNRA) located at Adiopodoumé (North Abidjan-Côte d'Ivoire) while the fruit samples were collected from Yapo a protected forest area with very humid equatorial climate. The experimental design was factorial design with two factors. Seeds processed from green fruits of 6 weeks old did not germinate, whilst those of 10 weeks old fruits, at the intermediate stage, germinated at the rate of 46%. Seeds from orange-coloured mature fruits had a germination rate of 54 to 62%. The adventitious roots of intermediate maturity seeds protruded at the same time as mature ones after 9 weeks of sowing and normal germination, with first shoot growth occurring simultaneously after 12 weeks in the two (intermediate maturity and full maturity) stage of fruits. Desiccation tests after 4 weeks revealed similar trends of weight decrease and moisture content in the two kinds of seed. Seeds from partly intermediate mature fruits showed germinating characteristics comparable to mature fruits. These indicate that the seeds from this stage could be used to germinate Garcinia kola Heckel, for conservation, post harvesting and commercial purposes.

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Antibacterial Interaction of Crude Methanol Extract of <i>Garcinia kola</i> Seed with Gatifloxacin

Cited by 9 publications

References 6 publications

Antibacterial Activities of Selected Cameroonian Plants and Their Synergistic Effects with Antibiotics against Bacteria Expressing MDR Phenotypes

Antibacterial Activities of Selected Cameroonian Plants and Their Synergistic Effects with Antibiotics against Bacteria Expressing MDR Phenotypes

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Possibility of using the intermediate mature stage of Garcinia kola heckel seeds to shorten the germination time

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